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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.01.2005 | Original Article

¹¹C-methionine PET as a prognostic marker in patients with glioma: comparison with¹⁸F-FDG PET

verfasst von: Sungeun Kim, June-Key Chung, So-Hyang Im, Jae Min Jeong, Dong Soo Lee, Dong Gyu Kim, Hee Won Jung, Myung Chul Lee

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 1/2005

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Abstract

Purpose

The purpose of this study was to compare the prognostic value of¹¹C-methionine (MET) and¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in glioma patients.

Methods

The study population comprised 47 patients with gliomas (19 glioblastoma, 28 others). Pretreatment magnetic resonance imaging, MET PET and FDG PET were performed within a time interval of 2 weeks in all patients. The uptake ratio and standard uptake values were calculated. Univariate and multivariate analyses were done to determine significant prognostic factors. Ki-67 index was measured by immunohistochemical staining, and compared with FDG and MET uptake in glioma.

Results

Among the several clinicopathological prognostic factors, tumour pathology (glioblastoma or not), age (≥60 or <60 years), Karnofsky performance status (KPS) (≥70 or <70) and MET PET (higher uptake or not compared with normal cortex) were found to be significant predictors by univariate analysis. In multivariate analysis, tumour pathology, KPS and MET PET were identified as significant independent predictors. The Ki-67 proliferation index was significantly correlated with MET uptake (r=0.64), but not with FDG uptake.

Conclusion

Compared with FDG PET in glioma, MET PET was an independent significant prognostic factor and MET uptake was correlated with cellular proliferation. MET PET may be a useful biological prognostic marker in glioma patients.

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Titel: 11C-methionine PET as a prognostic marker in patients with glioma: comparison with 18F-FDG PET
verfasst von: Sungeun Kim
June-Key Chung
So-Hyang Im
Jae Min Jeong
Dong Soo Lee
Dong Gyu Kim
Hee Won Jung
Myung Chul Lee
Publikationsdatum: 01.01.2005
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 1/2005
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-004-1598-6

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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