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European Journal of Nuclear Medicine and Molecular Imaging

01.04.2005 | Original Article

Hyperpolarised ³He MRI and ^81mKr SPECT in chronic obstructive pulmonary disease

verfasst von: Trine Stavngaard, Lise Vejby Søgaard, Jann Mortensen, Lars G. Hanson, Jörg Schmiedeskamp, Anne Kiil Berthelsen, Asger Dirksen

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 4/2005

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Abstract

Purpose

During recent years, magnetic resonance imaging (MRI) using hyperpolarised (HP) ³He gas has emerged as a promising new method for the imaging of lung ventilation. However, systematic comparisons with nuclear medicine techniques have not yet been performed. The aim of this study was to compare ventilation imaging methods in 26 patients with chronic obstructive pulmonary disease (COPD) and nine lung healthy volunteers.

Methods

HP ³He MRI, ^81mKr single-photon emission computed tomography (SPECT), high-resolution computed tomography (HRCT) and pulmonary function tests were performed. The three scans were scored visually as percentage of non-ventilated/diseased lung, and a computer-based objective measure of the ventilated volume in HP ³He MRI and ^81mKr SPECT and an emphysema index in HRCT were calculated.

Results

We found a good correlation between HP ³He MRI and ^81mKr SPECT for both visual defect score (r=0.80, p<0.0001) and objective estimate of ventilation (r=0.45, p=0.0157). In addition, both scans were well correlated with reference methods for the diagnosis of emphysema (pulmonary function test and HRCT). The defect scores were largest on ^81mKr SPECT (the score on HP ³He MRI was one-third less than that on ^81mKr SPECT), but the difference was reduced after normalisation for different breathing depths (HP ³He MRI at total lung capacity; ^81mKr SPECT at tidal breathing at functional residual capacity).

Conclusion

HP ³He MRI provides detailed ventilation distribution images and defect scores are comparable on HP ³He MRI and ^81mKr SPECT. Additionally, new insights into the regional pulmonary microstructure via the apparent diffusion coefficient measurements are provided by HP ³He MRI. HP ³He MRI is a promising new diagnostic tool for the assessment of ventilation distribution.

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Titel: Hyperpolarised 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease
verfasst von: Trine Stavngaard
Lise Vejby Søgaard
Jann Mortensen
Lars G. Hanson
Jörg Schmiedeskamp
Anne Kiil Berthelsen
Asger Dirksen
Publikationsdatum: 01.04.2005
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 4/2005
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-004-1691-x