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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.06.2005 | Image of the Month

⁶⁸Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5

verfasst von: Damian Wild, Helmut R. Mäcke, Beatrice Waser, Jean Claude Reubi, Mihaela Ginj, Helmut Rasch, Jan Müller-Brand, Michael Hofmann

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2005

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Existing somatostatin-based radiotracers (e.g. ¹¹¹In-DOTATOC) have sole affinity for somatostatin receptor subtype 2 (sst₂). This represents a drawback, given that sst_1–5 have been shown to be over-expressed in different tumours, alone or concomitantly [1]. Our goal, therefore, was to develop radiopeptides with broader receptor subtype profiles. …

Reubi JC, Waser B. Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting. Eur J Nucl Med Mol Imaging (Review) 2003;30:781–93.

Wild D, Schmitt JS, Ginj M, Macke HR, Bernard BF, Krenning E, et al. DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals. Eur J Nucl Med Mol Imaging 2003;30:1338–47.CrossRefPubMed

Hofmann M, Maecke HR, Börner AR, Weckesser E, Schöffski P, Oei ML, et al. Biokinetics and imaging with the somatostatin receptor PET radioligand ⁶⁸Ga-DOTATOC: preliminary data. Eur J Nucl Med 2001;28:1751–7.CrossRefPubMed

Titel: 68Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5
verfasst von: Damian Wild
Helmut R. Mäcke
Beatrice Waser
Jean Claude Reubi
Mihaela Ginj
Helmut Rasch
Jan Müller-Brand
Michael Hofmann
Publikationsdatum: 01.06.2005
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2005
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-004-1697-4

Springer Medizin

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