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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.06.2005 | Original Article

In vivo uptake of [¹¹C]choline does not correlate with cell proliferation in human prostate cancer

verfasst von: Anthonius J. Breeuwsma, Jan Pruim, Maud M. Jongen, Albert J. Suurmeijer, Wim Vaalburg, Rien J. Nijman, Igle J. de Jong

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2005

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Abstract

Purpose

Prostate cancer is the second leading cause of death from cancer among US men. Positron emission tomography (PET) with [¹¹C]choline has been shown to be useful in the staging and detection of prostate cancer. The background of the increased uptake of choline in human prostate cancer is not completely understood. The aim of this study was to prospectively investigate the relationship between the [¹¹C]choline uptake and the cell proliferation in human prostate cancer.

Methods

Prostate cancer tissue from 18 patients who had undergone a radical prostatectomy for histologically proven disease was studied. An [¹¹C]choline PET scan was performed prior to surgery. Post-prostatectomy specimens were prepared and stained with the antibody MIB-1 for Ki-67, which depicts proliferation. Two independent observers counted the amount of stained nuclei per specimen.

Results

Prostate cancer showed Ki-67 staining and high uptake of [¹¹C]choline. Statistical analysis showed no significant correlation between [¹¹C]choline uptake and Ki-67 staining (R=0.23; P=0.34). No significant relationships were found between the uptake of [¹¹C]choline (SUV) and either preoperative PSA (R=0.14; P=0.55) or Gleason sum score (R=0.28; P=0.25).

Conclusion

In vivo uptake of [¹¹C]choline does not correlate with cell proliferation in human prostate cancer as depicted by Ki-67. Our results suggest that a process other than proliferation is responsible for the uptake of [¹¹C]choline in prostate cancer.

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Titel: In vivo uptake of [11C]choline does not correlate with cell proliferation in human prostate cancer
verfasst von: Anthonius J. Breeuwsma
Jan Pruim
Maud M. Jongen
Albert J. Suurmeijer
Wim Vaalburg
Rien J. Nijman
Igle J. de Jong
Publikationsdatum: 01.06.2005
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2005
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-004-1741-4

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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