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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 9/2006

01.09.2006 | Original article

IBZM tool: a fully automated expert system for the evaluation of IBZM SPECT studies

verfasst von: Ralph Buchert, Georg Berding, Florian Wilke, Brigitte Martin, Daniel von Borczyskowski, Janos Mester, Winfried Brenner, Malte Clausen

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 9/2006

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Abstract

Purpose

Visual reading of [123I]IBZM SPECT scans depends on the experience of the interpreter. Therefore, semi-quantification of striatal IBZM uptake is commonly considered mandatory. However, semi-quantification is time consuming and prone to error, particularly if the volumes of interest (VOIs) are positioned manually. Therefore, the present paper proposes a new software tool (“IBZM tool”) for fully automated and standardised processing, evaluation and documentation of [123I]IBZM SPECT scans.

Methods

The IBZM tool is an easy-to-use SPM toolbox. It includes automated procedures for realignment and summation of multiple frames (motion correction), stereotactic normalisation, scaling, VOI analysis of striatum-to-reference ratio R, classification of R and standardised display. In order to evaluate the tool, which was developed at the University of Hamburg, the tool was transferred to the University of Hannover. There it was applied to 27 well-documented subjects: eight patients with multi-system atrophy (MSA), 12 patients with Parkinson’s disease (PD) and seven controls. The IBZM tool was compared with manual VOI analysis.

Results

The sensitivity and specificity of the IBZM tool for the differentiation of the MSA subjects from the controls were 100% and 86%, respectively. The IBZM tool provided improved statistical power compared with manual VOI analysis.

Conclusion

The IBZM tool is an expert system for the detection of reduced striatal D2 availability on [123I]IBZM SPECT scans. The standardised documentation supports visual and semi-quantitative evaluation, and it is useful for presenting the findings to the referring physician. The IBZM tool has the potential for widespread use, since it appears to be fairly independent of the performance characteristics of the particular SPECT system used. The tool is available free of charge.
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Metadaten
Titel
IBZM tool: a fully automated expert system for the evaluation of IBZM SPECT studies
verfasst von
Ralph Buchert
Georg Berding
Florian Wilke
Brigitte Martin
Daniel von Borczyskowski
Janos Mester
Winfried Brenner
Malte Clausen
Publikationsdatum
01.09.2006
Verlag
Springer-Verlag
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 9/2006
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-006-0067-9

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