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Erschienen in:
01.03.2009 | Short Communication
Metabolic–flow relationships in primary breast cancer: feasibility of combined PET/dynamic contrast-enhanced CT
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 3/2009
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Purpose
To assess the feasibility and first experience of combined 18F-FDG-PET)/dynamic contrast-enhanced (DCE) CT in evaluating breast cancer.
Methods
Nine consecutive female patients (mean age 64.2 years, range 52–74 years) with primary breast carcinoma were prospectively recruited for combined 18F-FDG PET/DCE-CT. Dynamic CT data were used to calculate a range of parameters of tumour vascularity, and tumour 18F-FDG uptake (standardized uptake value, SUVmax) was used as a metabolic indicator.
Results
One tumour did not enhance and was excluded. The mean tumour SUVmax was 7.7 (range 2.4–26.1). The mean values for tumour perfusion, perfusion normalized to cardiac output, standard perfusion value (SPV) and permeability were 41 ml/min per 100 g (19–59 ml/min per 100 g), 0.56%/100 g (0.33–1.09%/100 g), 3.6 (2.5–5.9) and 0.15/min (0.09–0.30/min), respectively. Linear regression analysis showed a positive correlation between tumour SUV and tumour perfusion normalized to cardiac output (r=0.55, p=0.045) and a marginal correlation between tumour SUV and tumour SPV (r=0.19, p=0.065). There were no significant correlations between tumour SUV and tumour perfusion (r=0.29, p=0.401) or permeability (r=0.03, p=0.682).
Conclusion
The first data from combined 18F-FDG-PET/DCE-CT in breast cancer are reported. The technique was successful in eight of nine patients. Breast tumour metabolic and vascular parameters were consistent with previous data from 15O-H2O-PET.