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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.06.2009 | Original Article

Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification

verfasst von: Laure Joly, Wassila Djaballah, Gregory Koehl, Damien Mandry, Gilles Dolivet, Pierre-Yves Marie, Athanase Benetos

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2009

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Abstract

Purpose

To analyse the relationship between: (i) aortic pulse wave velocity (PWV), an index of aortic stiffness with strong prognostic significance, and (ii) aortic calcification and inflammation, which were quantified by hybrid imaging with X-ray computed tomography (CT) and ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET).

Methods

Central aortic (carotid-femoral) and peripheral (carotid-brachial and femoral-tibial) PWV were recorded in 26 patients, who had been routinely referred for dual FDG-PET/CT imaging.

Results

In univariate analyses, central aortic PWV was strongly linked to the volume of calcifications (VCa) and an enhanced FDG activity, when determined by averaging standardized uptake values (SUV_max). By multivariate stepwise analysis including age and gender, both VCa (p < 0.0001) and SUV_max (p < 0.01) were significant determinants of PWV explaining 61% and 11% of its variability.

Conclusion

Aortic inflammation, assessed by hybrid FDG-PET/CT imaging, is associated with an enhanced aortic stiffness, in addition to the concurrent impact of calcifications.

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Titel: Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification
verfasst von: Laure Joly
Wassila Djaballah
Gregory Koehl
Damien Mandry
Gilles Dolivet
Pierre-Yves Marie
Athanase Benetos
Publikationsdatum: 01.06.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2009
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-008-1047-z

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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