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European Journal of Nuclear Medicine and Molecular Imaging

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01.10.2009 | Original Article

Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT

verfasst von: Andrea Varrone, Nils Sjöholm, Lars Eriksson, Balazs Gulyás, Christer Halldin, Lars Farde

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 10/2009

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Abstract

Purpose

Image reconstruction including the modelling of the point spread function (PSF) is an approach improving the resolution of the PET images. This study assessed the quantitative improvements provided by the implementation of the PSF modelling in the reconstruction of the PET data using the High Resolution Research Tomograph (HRRT).

Methods

Measurements were performed on the NEMA-IEC/2001 (Image Quality) phantom for image quality and on an anthropomorphic brain phantom (STEPBRAIN). PSF reconstruction was also applied to PET measurements in two cynomolgus monkeys examined with [¹⁸F]FE-PE2I (dopamine transporter) and with [¹¹C]MNPA (D₂ receptor), and in one human subject examined with [¹¹C]raclopride (D₂ receptor).

Results

PSF reconstruction increased the recovery coefficient (RC) in the NEMA phantom by 11–40% and the grey to white matter ratio in the STEPBRAIN phantom by 17%. PSF reconstruction increased binding potential (BP _ND) in the striatum and midbrain by 14 and 18% in the [¹⁸F]FE-PE2I study, and striatal BP _ND by 6 and 10% in the [¹¹C]MNPA and [¹¹C]raclopride studies.

Conclusion

PSF reconstruction improved quantification by increasing the RC and thus reducing the partial volume effect. This method provides improved conditions for PET quantification in clinical studies with the HRRT system, particularly when targeting receptor populations in small brain structures.

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Titel: Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT
verfasst von: Andrea Varrone
Nils Sjöholm
Lars Eriksson
Balazs Gulyás
Christer Halldin
Lars Farde
Publikationsdatum: 01.10.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 10/2009
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-009-1156-3

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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