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European Journal of Nuclear Medicine and Molecular Imaging

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01.03.2011 | Original Article

Correlation of high ¹⁸F-FDG uptake to clinical, pathological and biological prognostic factors in breast cancer

verfasst von: David Groheux, Sylvie Giacchetti, Jean-Luc Moretti, Raphael Porcher, Marc Espié, Jacqueline Lehmann-Che, Anne de Roquancourt, Anne-Sophie Hamy, Caroline Cuvier, Laetitia Vercellino, Elif Hindié

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 3/2011

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Abstract

Purpose

The aim of this study was to determine the impact of the main clinicopathological and biological prognostic factors of breast cancer on ¹⁸F-fluorodeoxyglucose (FDG) uptake. Only women with tumours larger than 20 mm (T2–T4) were included in order to minimize bias of partial volume effect.

Methods

In this prospective study, 132 consecutive women received FDG PET/CT imaging before starting neoadjuvant chemotherapy. Maximum standardized uptake values (SUV_max) were compared to tumour characteristics as assessed on core biopsy.

Results

There was no influence of T and N stage on SUV. Invasive ductal carcinoma showed higher SUV than lobular carcinoma. However, the highest uptake was found for metaplastic tumours, representing 5% of patients in this series. Several biological features usually considered as bad prognostic factors were associated with an increase in FDG uptake: the median of SUV_max was 9.7 for grade 3 tumours vs 4.8 for the lower grades (p < 0.0001); negativity for oestrogen receptors (ER) was associated with higher SUV (ER+ SUV = 5.5; ER− SUV = 7.6; p = 0.003); triple-negative tumours (oestrogen and progesterone receptor negative, no overexpression of c-erbB-2) had an SUV of 9.2 vs 5.8 for all others (p = 0005); p53 mutated tumours also had significantly higher SUV (7.8 vs 5.0; p < 0.0001). Overexpression of c-erbB-2 had no effect on the SUV value.

Conclusion

Knowledge of the factors influencing uptake is important when interpreting FDG PET/CT scans. Also, findings that FDG uptake is highest in those patients with poor prognostic features (high grade, hormone receptor negativity, triple negativity, metaplastic tumours) is helpful to determine who are the best candidates for baseline staging.

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Titel: Correlation of high 18F-FDG uptake to clinical, pathological and biological prognostic factors in breast cancer
verfasst von: David Groheux
Sylvie Giacchetti
Jean-Luc Moretti
Raphael Porcher
Marc Espié
Jacqueline Lehmann-Che
Anne de Roquancourt
Anne-Sophie Hamy
Caroline Cuvier
Laetitia Vercellino
Elif Hindié
Publikationsdatum: 01.03.2011
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 3/2011
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-010-1640-9

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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