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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.11.2011 | Original Article

Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography

verfasst von: Michael Fiechter, Jelena R. Ghadri, Silke M. Kuest, Aju P. Pazhenkottil, Mathias Wolfrum, Rene N. Nkoulou, Robert Goetti, Oliver Gaemperli, Philipp A. Kaufmann

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 11/2011

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Abstract

Purpose

We evaluated the diagnostic accuracy of attenuation corrected nuclear myocardial perfusion imaging (MPI) with a novel hybrid single photon emission computed tomography (SPECT)/CT device consisting of an ultrafast dedicated cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors integrated onto a multislice CT scanner to detect coronary artery disease (CAD). Invasive coronary angiography served as the standard of reference.

Methods

The study population included 66 patients (79% men; mean age 63 ± 11 years) who underwent 1-day ^99mTc-tetrofosmin pharmacological stress/rest examination and angiography within 3 months. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as accuracy of the CT X-ray based attenuation corrected CZT MPI for detection of CAD (≥50% luminal narrowing) was calculated on a per-patient basis.

Results

The prevalence of angiographic CAD in the study population was 82%. Sensitivity, specificity, PPV, NPV and accuracy were 87, 67, 92, 53 and 83%, respectively.

Conclusion

In this first report on CZT SPECT/CT MPI comparison versus angiography we confirm a high accuracy for detection of angiographically documented CAD.

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Titel: Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography
verfasst von: Michael Fiechter
Jelena R. Ghadri
Silke M. Kuest
Aju P. Pazhenkottil
Mathias Wolfrum
Rene N. Nkoulou
Robert Goetti
Oliver Gaemperli
Philipp A. Kaufmann
Publikationsdatum: 01.11.2011
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 11/2011
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-011-1877-y

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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