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European Journal of Nuclear Medicine and Molecular Imaging

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01.02.2012 | Review Article

¹¹¹In-DTPA⁰-octreotide (Octreoscan), ¹³¹I-MIBG and other agents for radionuclide therapy of NETs

verfasst von: Jamshed B. Bomanji, Nikolaos D. Papathanasiou

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Sonderheft 1/2012

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Abstract

This paper is a critical review of the literature on NET radionuclide therapy with ¹¹¹In-DTPA⁰-octreotide (Octreoscan) and ¹³¹I-MIBG, focusing on efficacy and toxicity. Some potential future applications and new candidate therapeutic agents are also mentioned. Octreoscan has been a pioneering agent for somatostatin receptor radionuclide therapy. It has achieved symptomatic responses and disease stabilization, but it is now outperformed by the corresponding β-emitter agents ¹⁷⁷Lu-DOTATATE and ⁹⁰Y-DOTATOC. ¹³¹I-MIBG is the radionuclide therapy of choice for inoperable or metastatic phaeochromocytomas/paragangliomas, which avidly concentrate this tracer via the noradrenaline transporter. Symptomatic, biochemical and tumour morphological response rates of 50–89%, 45–74% and 27–47%, respectively, have been reported. ¹³¹I-MIBG is a second-line radiopharmaceutical for treatment of enterochromaffin carcinoids, mainly offering the benefit of amelioration of hormone-induced symptoms. High specific activity, non-carrier-added ¹³¹I-MIBG and meta-astato(²¹¹At)-benzylguanidine (MABG) are tracers with potential for enhanced therapeutic efficacy, yet their integration into clinical practice awaits further exploration. Amongst other promising agents, radiolabelled exendin analogues show potential for imaging and possibly therapy of insulinomas, while preclinical studies are currently evaluating DOTA peptides targeting the CCK-2/gastrin receptors that are overexpressed by medullary thyroid carcinoma cells.

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Titel: 111In-DTPA0-octreotide (Octreoscan), 131I-MIBG and other agents for radionuclide therapy of NETs
verfasst von: Jamshed B. Bomanji
Nikolaos D. Papathanasiou
Publikationsdatum: 01.02.2012
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe Sonderheft 1/2012
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-011-2013-8

Springer Medizin

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