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Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 10/2014

01.10.2014 | Editorial

Whither peptide receptor radionuclide therapy for neuroendocrine tumors: an Einsteinian view of the facts and myths

verfasst von: Vikas Prasad, Lisa Bodei, Mark Kidd, Irvin M. Modlin

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 10/2014

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Excerpt

One should always be cautious of undertaking a rigorous examination of a subject lest hubris interferes with balance and the confidence of “experience” undermines the rigor of facts. Notwithstanding these caveats, this missive seeks to cast a critical light on what, to date, has proven to be a contentious subject: the utility of peptide receptor radionuclide therapy (PRRT) in the management strategy of neuroendocrine tumors (NETs). Mindful of the Einsteinian adage—“whoever undertakes to set himself up as a judge of Truth and Knowledge is shipwrecked by the laughter of the gods” [1]—we propose to provide a balanced assessment of the matter from the perspective of evaluators of the therapy as opposed to purveyors. …
Literatur
1.
Zurück zum Zitat Einstein A. Ideas and opinions. New York: Crown; 1954. Einstein A. Ideas and opinions. New York: Crown; 1954.
5.
9.
Zurück zum Zitat Oberg K, Kvols L, Caplin M, Delle Fave G, de Herder W, Rindi G, et al. Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system. Ann Oncol 2004;15:966–73.PubMedCrossRef Oberg K, Kvols L, Caplin M, Delle Fave G, de Herder W, Rindi G, et al. Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system. Ann Oncol 2004;15:966–73.PubMedCrossRef
10.
Zurück zum Zitat Hofland LJ, Lamberts SW. The pathophysiological consequences of somatostatin receptor internalization and resistance. Endocr Rev 2003;24:28–47.PubMedCrossRef Hofland LJ, Lamberts SW. The pathophysiological consequences of somatostatin receptor internalization and resistance. Endocr Rev 2003;24:28–47.PubMedCrossRef
11.
Zurück zum Zitat Rinke A, Müller HH, Schade-Brittinger C, Klose KJ, Barth P, Wied M, et al. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol 2009;27:4656–63.PubMedCrossRef Rinke A, Müller HH, Schade-Brittinger C, Klose KJ, Barth P, Wied M, et al. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol 2009;27:4656–63.PubMedCrossRef
12.
Zurück zum Zitat Kidd M, Schally AV, Pfragner R, Malfertheiner MV, Modlin IM. Inhibition of proliferation of small intestinal and bronchopulmonary neuroendocrine cell lines by using peptide analogs targeting receptors. Cancer 2008;112:1404–14.PubMedCrossRef Kidd M, Schally AV, Pfragner R, Malfertheiner MV, Modlin IM. Inhibition of proliferation of small intestinal and bronchopulmonary neuroendocrine cell lines by using peptide analogs targeting receptors. Cancer 2008;112:1404–14.PubMedCrossRef
13.
Zurück zum Zitat Kidd M, Drozdov I, Joseph R, Pfragner R, Culler M, Modlin I. Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines. Cancer 2008;113:690–700. doi:10.1002/cncr.23700.PubMedCentralPubMedCrossRef Kidd M, Drozdov I, Joseph R, Pfragner R, Culler M, Modlin I. Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines. Cancer 2008;113:690–700. doi:10.​1002/​cncr.​23700.PubMedCentralPubMedCrossRef
14.
Zurück zum Zitat Susini C, Buscail L. Rationale for the use of somatostatin analogs as antitumor agents. Ann Oncol 2006;17:1733–42.PubMedCrossRef Susini C, Buscail L. Rationale for the use of somatostatin analogs as antitumor agents. Ann Oncol 2006;17:1733–42.PubMedCrossRef
16.
Zurück zum Zitat Cescato R, Loesch KA, Waser B, Mäcke HR, Rivier JE, Reubi JC, et al. Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways. Mol Endocrinol 2010;24:240–9. doi:10.1210/me.2009-0321.PubMedCentralPubMedCrossRef Cescato R, Loesch KA, Waser B, Mäcke HR, Rivier JE, Reubi JC, et al. Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways. Mol Endocrinol 2010;24:240–9. doi:10.​1210/​me.​2009-0321.PubMedCentralPubMedCrossRef
17.
Zurück zum Zitat Caplin M, Ruszniewski P, Pavel M, et al. A randomized double-blind placebo-controlled study of lanreotide antiproliferative response in patients with enteropancreatic neuroendocrine tumours (CLARINET). 17th ECCO-38th ESMO-32nd ESTRO European Cancer Congress. Amsterdam; 2013. p. Abstract E17-7103. Caplin M, Ruszniewski P, Pavel M, et al. A randomized double-blind placebo-controlled study of lanreotide antiproliferative response in patients with enteropancreatic neuroendocrine tumours (CLARINET). 17th ECCO-38th ESMO-32nd ESTRO European Cancer Congress. Amsterdam; 2013. p. Abstract E17-7103.
18.
Zurück zum Zitat Wolin EM. PI3K/Akt/mTOR pathway inhibitors in the therapy of pancreatic neuroendocrine tumors. Cancer Lett 2013;335:1–8.PubMedCrossRef Wolin EM. PI3K/Akt/mTOR pathway inhibitors in the therapy of pancreatic neuroendocrine tumors. Cancer Lett 2013;335:1–8.PubMedCrossRef
19.
Zurück zum Zitat Faivre S, Castellano D, Strosberg J, Gonzalez E, Salazar R. Pancreatic NETs: where do we stand now? Cancer Metastasis Rev 2014;33:361–6.CrossRef Faivre S, Castellano D, Strosberg J, Gonzalez E, Salazar R. Pancreatic NETs: where do we stand now? Cancer Metastasis Rev 2014;33:361–6.CrossRef
20.
Zurück zum Zitat Dahan L, Bonnetain F, Rougier P, Raoul JL, Gamelin E, Etienne PL, et al. Phase III trial of chemotherapy using 5-fluorouracil and streptozotocin compared with interferon alpha for advanced carcinoid tumors: FNCLCC-FFCD 9710. Endocr Relat Cancer 2009;16:1351–61.PubMedCrossRef Dahan L, Bonnetain F, Rougier P, Raoul JL, Gamelin E, Etienne PL, et al. Phase III trial of chemotherapy using 5-fluorouracil and streptozotocin compared with interferon alpha for advanced carcinoid tumors: FNCLCC-FFCD 9710. Endocr Relat Cancer 2009;16:1351–61.PubMedCrossRef
21.
Zurück zum Zitat Strosberg JR, Fine RL, Choi J, Nasir A, Coppola D, Chen DT, et al. First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer 2011;117:268–75. doi:10.1002/cncr.25425.PubMedCrossRef Strosberg JR, Fine RL, Choi J, Nasir A, Coppola D, Chen DT, et al. First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer 2011;117:268–75. doi:10.​1002/​cncr.​25425.PubMedCrossRef
22.
Zurück zum Zitat Strosberg JR, Fisher GA, Benson AB, Malin JL, GEPNET Treatment Consensus Panel, Cherepanov D, Broder MS, et al. Systemic treatment in unresectable metastatic well-differentiated carcinoid tumors: consensus results from a modified delphi process. Pancreas 2013;42:397–404. doi:10.1097/MPA.0b013e31826d3a17.PubMedCrossRef Strosberg JR, Fisher GA, Benson AB, Malin JL, GEPNET Treatment Consensus Panel, Cherepanov D, Broder MS, et al. Systemic treatment in unresectable metastatic well-differentiated carcinoid tumors: consensus results from a modified delphi process. Pancreas 2013;42:397–404. doi:10.​1097/​MPA.​0b013e31826d3a17​.PubMedCrossRef
23.
Zurück zum Zitat Bodei L, Mueller-Brand J, Baum RP, Pavel ME, Horsch D, O’Dorisio MS, et al. Erratum to: the joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours. Eur J Nucl Med Mol Imaging 2014;41:584. doi:10.1007/s00259-013-2454-3.CrossRef Bodei L, Mueller-Brand J, Baum RP, Pavel ME, Horsch D, O’Dorisio MS, et al. Erratum to: the joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours. Eur J Nucl Med Mol Imaging 2014;41:584. doi:10.​1007/​s00259-013-2454-3.CrossRef
24.
Zurück zum Zitat Tubiana M, Dutreix J, Wambersie A, editors. Introduction to radiobiology. Intrinsic cellular radiosensitivity, chap. 4.4. London: Taylor & Francis; 1990. Tubiana M, Dutreix J, Wambersie A, editors. Introduction to radiobiology. Intrinsic cellular radiosensitivity, chap. 4.4. London: Taylor & Francis; 1990.
25.
Zurück zum Zitat Pauwels S, Barone R, Walrand S, Borson-Chazot F, Valkema R, Kvols LK, et al. Practical dosimetry of peptide receptor radionuclide therapy with (90)Y-labeled somatostatin analogs. J Nucl Med 2005;46:92S–8S.PubMed Pauwels S, Barone R, Walrand S, Borson-Chazot F, Valkema R, Kvols LK, et al. Practical dosimetry of peptide receptor radionuclide therapy with (90)Y-labeled somatostatin analogs. J Nucl Med 2005;46:92S–8S.PubMed
26.
Zurück zum Zitat Kwekkeboom DJ, de Herder WW, Kam BL, van Eijck CH, van Essen M, Kooij PP, et al. Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0, Tyr3]octreotate: toxicity, efficacy, and survival. J Clin Oncol 2008;26:2124–30.PubMedCrossRef Kwekkeboom DJ, de Herder WW, Kam BL, van Eijck CH, van Essen M, Kooij PP, et al. Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0, Tyr3]octreotate: toxicity, efficacy, and survival. J Clin Oncol 2008;26:2124–30.PubMedCrossRef
27.
Zurück zum Zitat Imhof A, Brunner P, Marincek N, Briel M, Schindler C, Rasch H, et al. Response, survival, and long-term toxicity after therapy with the radiolabeled somatostatin analogue [90Y-DOTA]-TOC in metastasized neuroendocrine cancers. J Clin Oncol 2011;29:2416–23.PubMedCrossRef Imhof A, Brunner P, Marincek N, Briel M, Schindler C, Rasch H, et al. Response, survival, and long-term toxicity after therapy with the radiolabeled somatostatin analogue [90Y-DOTA]-TOC in metastasized neuroendocrine cancers. J Clin Oncol 2011;29:2416–23.PubMedCrossRef
28.
Zurück zum Zitat Ruszniewski P, Ish-Shalom S, Wymenga M, O’Toole D, Arnold R, Tomassetti P, et al. Rapid and sustained relief from the symptoms of carcinoid syndrome: results from an open 6-month study of the 28-day prolonged-release formulation of lanreotide. Neuroendocrinology 2004;80:244–51.PubMedCrossRef Ruszniewski P, Ish-Shalom S, Wymenga M, O’Toole D, Arnold R, Tomassetti P, et al. Rapid and sustained relief from the symptoms of carcinoid syndrome: results from an open 6-month study of the 28-day prolonged-release formulation of lanreotide. Neuroendocrinology 2004;80:244–51.PubMedCrossRef
29.
Zurück zum Zitat Bushnell Jr DL, O’Dorisio TM, O’Dorisio MS, Menda Y, Hicks RJ, Van Cutsem E, et al. 90Y-edotreotide for metastatic carcinoid refractory to octreotide. J Clin Oncol 2010;28:1652–9.PubMedCrossRef Bushnell Jr DL, O’Dorisio TM, O’Dorisio MS, Menda Y, Hicks RJ, Van Cutsem E, et al. 90Y-edotreotide for metastatic carcinoid refractory to octreotide. J Clin Oncol 2010;28:1652–9.PubMedCrossRef
30.
Zurück zum Zitat Khan S, Krenning EP, van Essen M, Kam BL, Teunissen JJ, Kwekkeboom DJ. Quality of life in 265 patients with gastroenteropancreatic or bronchial neuroendocrine tumors treated with [177Lu-DOTA0,Tyr3]octreotate. J Nucl Med 2011;52:1361–8.PubMedCrossRef Khan S, Krenning EP, van Essen M, Kam BL, Teunissen JJ, Kwekkeboom DJ. Quality of life in 265 patients with gastroenteropancreatic or bronchial neuroendocrine tumors treated with [177Lu-DOTA0,Tyr3]octreotate. J Nucl Med 2011;52:1361–8.PubMedCrossRef
31.
Zurück zum Zitat Bodei L, Ferone D, Grana CM, Cremonesi M, Signore A, Dierckx RA, et al. Peptide receptor therapies in neuroendocrine tumors. J Endocrinol Invest 2009;32:360–9.PubMedCrossRef Bodei L, Ferone D, Grana CM, Cremonesi M, Signore A, Dierckx RA, et al. Peptide receptor therapies in neuroendocrine tumors. J Endocrinol Invest 2009;32:360–9.PubMedCrossRef
32.
Zurück zum Zitat Valkema R, Pauwels S, Kvols LK, Barone R, Jamar F, Bakker WH, et al. Survival and response after peptide receptor radionuclide therapy with [90Y-DOTA0, Tyr3]octreotide in patients with advanced gastroenteropancreatic neuroendocrine tumors. Semin Nucl Med 2006;36:147–56.PubMedCrossRef Valkema R, Pauwels S, Kvols LK, Barone R, Jamar F, Bakker WH, et al. Survival and response after peptide receptor radionuclide therapy with [90Y-DOTA0, Tyr3]octreotide in patients with advanced gastroenteropancreatic neuroendocrine tumors. Semin Nucl Med 2006;36:147–56.PubMedCrossRef
33.
Zurück zum Zitat Kuzel T, Rosen S. Radioimmunotherapy of lymphomas and leukemias. In: Henkin R, Boles M, Dillehay G, editors. Nuclear medicine. St. Louis: Mosby; 1996. p. 594–600. Kuzel T, Rosen S. Radioimmunotherapy of lymphomas and leukemias. In: Henkin R, Boles M, Dillehay G, editors. Nuclear medicine. St. Louis: Mosby; 1996. p. 594–600.
34.
Zurück zum Zitat Valkema R, Pauwels SA, Kvols LK, Kwekkeboom DJ, Jamar F, de Jong M, et al. Long-term follow-up of renal function after peptide receptor radiation therapy with (90)Y-DOTA(0), Tyr(3)-octreotide and (177)Lu-DOTA(0), Tyr(3)-octreotate. J Nucl Med 2005;46:83S–91S.PubMed Valkema R, Pauwels SA, Kvols LK, Kwekkeboom DJ, Jamar F, de Jong M, et al. Long-term follow-up of renal function after peptide receptor radiation therapy with (90)Y-DOTA(0), Tyr(3)-octreotide and (177)Lu-DOTA(0), Tyr(3)-octreotate. J Nucl Med 2005;46:83S–91S.PubMed
35.
Zurück zum Zitat Bodei L, Cremonesi M, Ferrari M, Pacifici M, Grana CM, Bartolomei M, et al. Long-term evaluation of renal toxicity after peptide receptor radionuclide therapy with 90Y-DOTATOC and 177Lu-DOTATATE: the role of associated risk factors. Eur J Nucl Med Mol Imaging 2008;35:1847–56.PubMedCrossRef Bodei L, Cremonesi M, Ferrari M, Pacifici M, Grana CM, Bartolomei M, et al. Long-term evaluation of renal toxicity after peptide receptor radionuclide therapy with 90Y-DOTATOC and 177Lu-DOTATATE: the role of associated risk factors. Eur J Nucl Med Mol Imaging 2008;35:1847–56.PubMedCrossRef
36.
Zurück zum Zitat Sandström M, Garske-Román U, Granberg D, Johansson S, Widström C, Eriksson B, et al. Individualized dosimetry of kidney and bone marrow in patients undergoing 177Lu-DOTA-octreotate treatment. J Nucl Med 2013;54:33–41. doi:10.2967/jnumed.112.107524.PubMedCrossRef Sandström M, Garske-Román U, Granberg D, Johansson S, Widström C, Eriksson B, et al. Individualized dosimetry of kidney and bone marrow in patients undergoing 177Lu-DOTA-octreotate treatment. J Nucl Med 2013;54:33–41. doi:10.​2967/​jnumed.​112.​107524.PubMedCrossRef
37.
Zurück zum Zitat Kwekkeboom DJ, Mueller-Brand J, Paganelli G, Anthony LB, Pauwels S, Kvols LK, et al. Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs. J Nucl Med 2005;46:62S–6S.PubMed Kwekkeboom DJ, Mueller-Brand J, Paganelli G, Anthony LB, Pauwels S, Kvols LK, et al. Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs. J Nucl Med 2005;46:62S–6S.PubMed
38.
Zurück zum Zitat Bodei L, Cremonesi M, Grana CM, Fazio N, Iodice S, Baio SM, et al. Peptide receptor radionuclide therapy with (177)Lu-DOTATATE: the IEO phase I-II study. Eur J Nucl Med Mol Imaging 2011;38:2125–35.PubMedCrossRef Bodei L, Cremonesi M, Grana CM, Fazio N, Iodice S, Baio SM, et al. Peptide receptor radionuclide therapy with (177)Lu-DOTATATE: the IEO phase I-II study. Eur J Nucl Med Mol Imaging 2011;38:2125–35.PubMedCrossRef
39.
Zurück zum Zitat Kwekkeboom D. EANM. In: Bodei L, editor.; 2013. Kwekkeboom D. EANM. In: Bodei L, editor.; 2013.
40.
Zurück zum Zitat Pfeifer AK, Gregersen T, Grønbæk H, Hansen CP, Müller-Brand J, Herskind Bruun K, et al. Peptide receptor radionuclide therapy with Y-DOTATOC and (177)Lu-DOTATOC in advanced neuroendocrine tumors: results from a Danish cohort treated in Switzerland. Neuroendocrinology 2011;93:189–96. doi:10.1159/000324096.PubMedCrossRef Pfeifer AK, Gregersen T, Grønbæk H, Hansen CP, Müller-Brand J, Herskind Bruun K, et al. Peptide receptor radionuclide therapy with Y-DOTATOC and (177)Lu-DOTATOC in advanced neuroendocrine tumors: results from a Danish cohort treated in Switzerland. Neuroendocrinology 2011;93:189–96. doi:10.​1159/​000324096.PubMedCrossRef
42.
Zurück zum Zitat Bodei L, Kidd M, Paganelli G, Grana C, Drozdov I, Cremonesi M, et al. Clinical features are not reliable in predicting long-term toxicity after PRRT—evidence from >800 patients to support genetic screen development. Barcelona: ENETs; 2014. Bodei L, Kidd M, Paganelli G, Grana C, Drozdov I, Cremonesi M, et al. Clinical features are not reliable in predicting long-term toxicity after PRRT—evidence from >800 patients to support genetic screen development. Barcelona: ENETs; 2014.
44.
Zurück zum Zitat Luster M, Hänscheid H, Freudenberg LS, Verburg FA. Radioiodine therapy of metastatic lesions of differentiated thyroid cancer. J Endocrinol Invest 2012;35:21–9.PubMed Luster M, Hänscheid H, Freudenberg LS, Verburg FA. Radioiodine therapy of metastatic lesions of differentiated thyroid cancer. J Endocrinol Invest 2012;35:21–9.PubMed
46.
Zurück zum Zitat Claringbold PG, Brayshaw PA, Price RA, Turner JH. Phase II study of radiopeptide 177Lu-octreotate and capecitabine therapy of progressive disseminated neuroendocrine tumours. Eur J Nucl Med Mol Imaging 2011;38:302–11. doi:10.1007/s00259-010-1631-x.PubMedCrossRef Claringbold PG, Brayshaw PA, Price RA, Turner JH. Phase II study of radiopeptide 177Lu-octreotate and capecitabine therapy of progressive disseminated neuroendocrine tumours. Eur J Nucl Med Mol Imaging 2011;38:302–11. doi:10.​1007/​s00259-010-1631-x.PubMedCrossRef
47.
Zurück zum Zitat Giesel FL, Wulfert S, Zechmann CM, Haberkorn U, Kratochwil C, Flechsig P, et al. Contrast-enhanced ultrasound monitoring of perfusion changes in hepatic neuroendocrine metastases after systemic versus selective arterial 177Lu/90Y-DOTATOC and 213Bi-DOTATOC radiopeptide therapy. Exp Oncol 2013;35:122–6.PubMed Giesel FL, Wulfert S, Zechmann CM, Haberkorn U, Kratochwil C, Flechsig P, et al. Contrast-enhanced ultrasound monitoring of perfusion changes in hepatic neuroendocrine metastases after systemic versus selective arterial 177Lu/90Y-DOTATOC and 213Bi-DOTATOC radiopeptide therapy. Exp Oncol 2013;35:122–6.PubMed
48.
Zurück zum Zitat de Mestier L, Dromain C, d’Assignies G, Scoazec JY, Lassau N, Lebtahi R, et al. Evaluating neuroendocrine tumors progression and therapeutic response: state of the art. Endocr Relat Cancer 2013. doi:10.1530/ERC-13-0365. de Mestier L, Dromain C, d’Assignies G, Scoazec JY, Lassau N, Lebtahi R, et al. Evaluating neuroendocrine tumors progression and therapeutic response: state of the art. Endocr Relat Cancer 2013. doi:10.​1530/​ERC-13-0365.
49.
Zurück zum Zitat van Vliet EI, Krenning EP, Teunissen JJ, Bergsma H, Kam BL, Kwekkeboom DJ. Comparison of response evaluation in patients with gastroenteropancreatic and thoracic neuroendocrine tumors after treatment with [177Lu-DOTA0, Tyr3]octreotate. J Nucl Med 2013;54:1689–96. doi:10.2967/jnumed.112.117408.PubMedCrossRef van Vliet EI, Krenning EP, Teunissen JJ, Bergsma H, Kam BL, Kwekkeboom DJ. Comparison of response evaluation in patients with gastroenteropancreatic and thoracic neuroendocrine tumors after treatment with [177Lu-DOTA0, Tyr3]octreotate. J Nucl Med 2013;54:1689–96. doi:10.​2967/​jnumed.​112.​117408.PubMedCrossRef
Metadaten
Titel
Whither peptide receptor radionuclide therapy for neuroendocrine tumors: an Einsteinian view of the facts and myths
verfasst von
Vikas Prasad
Lisa Bodei
Mark Kidd
Irvin M. Modlin
Publikationsdatum
01.10.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 10/2014
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-014-2780-0

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