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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.11.2014 | Original Article

Comparing amyloid-β deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: a PET study in aged monkeys

verfasst von: Hideo Tsukada, Shingo Nishiyama, Hiroyuki Ohba, Masakatsu Kanazawa, Takeharu Kakiuchi, Norihiro Harada

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 11/2014

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Abstract

Purpose

The aim of the present study was to compare amyloid-β (Aβ) deposition, translocator protein (TSPO) activity, regional cerebral metabolic rate of glucose (rCMRglc), and mitochondrial complex I (MC-I) activity in the brain of aged monkeys.

Methods

PET scans with ¹¹C-PIB (Aβ), ¹⁸F-BCPP-EF (MC-I), ¹¹C-DPA-713 (TSPO), and ¹⁸F-FDG (rCMRglc) were performed in aged monkeys (Macaca mulatta) in the conscious state and under isoflurane anaesthesia. ¹¹C-PIB binding to Aβ and ¹¹C-DPA-713 binding to TSPO were evaluated in terms of standard uptake values (SUV). The total volume of distribution (V _T) of ¹⁸F-BCPP-EF and rCMRglc with ¹⁸F-FDG were calculated using arterial blood sampling.

Results

Isoflurane did not affect MC-I activity measured in terms of ¹⁸F-BCPP-EF uptake in living brain. There was a significant negative correlation between ¹⁸F-BCPP-EF binding (V _T) and ¹¹C-PIB uptake (SUVR), and there was a significant positive correlation between ¹¹C-DPA-713 uptake (SUV) and ¹¹C-PIB uptake. In contrast, there was no significant correlation between rCMRglc ratio and ¹¹C-PIB uptake.

Conclusion

¹⁸F-BCPP-EF could be a potential PET probe for quantitative imaging of impaired MC-I activity that is correlated with Aβ deposition in the living brain.

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Titel: Comparing amyloid-β deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: a PET study in aged monkeys
verfasst von: Hideo Tsukada
Shingo Nishiyama
Hiroyuki Ohba
Masakatsu Kanazawa
Takeharu Kakiuchi
Norihiro Harada
Publikationsdatum: 01.11.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 11/2014
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-014-2821-8

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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