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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 10/2020

22.02.2020 | Letter to the Editor

Anatomy of 18F-GE180, a failed radioligand for the TSPO protein

verfasst von: Paolo Zanotti-Fregonara, Belen Pascual, Robert C. Rostomily, Gaia Rizzo, Mattia Veronese, Joseph C. Masdeu, Federico Turkheimer

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 10/2020

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Excerpt

Few translocator protein (TSPO) radioligands have been rapidly translated into human clinical research with the enthusiasm of 18F-GE180. Within two years from the publication of the first kinetic analyses in humans [1, 2], four clinical studies in patients with brain tumors [3, 4] and multiple sclerosis [5, 6], at least three case-reports [7‐9], and one editorial praising the “definitely superior” imaging qualities of 18F-GE180 [10] appeared in the literature. …
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Feeney C, Scott G, Raffel J, Roberts S, Coello C, Jolly A, et al. Kinetic analysis of the translocator protein positron emission tomography ligand [18F]GE-180 in the human brain. Eur J Nucl Med Mol Imaging. 2016;43:2201–10.CrossRef
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Albert NL, Unterrainer M, Fleischmann DF, Lindner S, Vettermann F, Brunegraf A, et al. TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma. Eur J Nucl Med Mol Imaging. 2017.
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Vomacka L, Albert NL, Lindner S, Unterrainer M, Mahler C, Brendel M, et al. TSPO imaging using the novel PET ligand [(18)F]GE-180: quantification approaches in patients with multiple sclerosis. EJNMMI Res. 2017;7:89.CrossRef
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Langen KJ, Willuweit A. TSPO PET using (18)F-GE-180: a new perspective in neurooncology? Eur J Nucl Med Mol Imaging. 2017;44:2227–9.CrossRef
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Sridharan S, Raffel J, Nandoskar A, Record C, Brooks DJ, Owen D, et al. Confirmation of specific binding of the 18-kDa translocator protein (TSPO) radioligand [(18)F]GE-180: a blocking study using XBD173 in multiple sclerosis normal appearing white and grey matter. Mol Imaging Biol. 2019.
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Unterrainer M, Fleischmann DF, Vettermann F, Ruf V, Kaiser L, Nelwan D, et al. TSPO PET, tumour grading and molecular genetics in histologically verified glioma: a correlative (18)F-GE-180 PET study. Eur J Nucl Med Mol Imaging. 2019.
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Nowosielski M, DiFranco MD, Putzer D, Seiz M, Recheis W, Jacobs AH, et al. An intra-individual comparison of MRI, [18F]-FET and [18F]-FLT PET in patients with high-grade gliomas. PLoS One. 2014;9:e95830.CrossRef
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Boutin H, Murray K, Pradillo J, Maroy R, Smigova A, Gerhard A, et al. 18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke. Eur J Nucl Med Mol Imaging. 2015;42:503–11.CrossRef
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de Groot M, Patel N, Manavaki R, Janiczek RL, Bergstrom M, Ostor A, et al. Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand (18)F-GE-180 and comparison with (18)F-FDG and DCE-MRI. EJNMMI Res. 2019;9:113.CrossRef
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Metadaten
Titel
Anatomy of 18F-GE180, a failed radioligand for the TSPO protein
verfasst von
Paolo Zanotti-Fregonara
Belen Pascual
Robert C. Rostomily
Gaia Rizzo
Mattia Veronese
Joseph C. Masdeu
Federico Turkheimer
Publikationsdatum
22.02.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 10/2020
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-020-04732-y

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