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Cancer Immunology, Immunotherapy

Erschienen in:

01.08.2011 | Review

Cooperativity of adaptive and innate immunity: implications for cancer therapy

verfasst von: Anil Shanker, Francesco M. Marincola

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 8/2011

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Abstract

The dichotomy of immunology into innate and adaptive immunity has created conceptual barriers in appreciating the intrinsic two-way interaction between immune cells. An emerging body of evidence in various models of immune rejection, including cancer, indicates an indispensable regulation of innate effector functions by adaptive immune cells. This bidirectional cooperativity in innate and adaptive immune functions has broad implications for immune responses in general and for regulating the tumor-associated inflammation that overrides the protective antitumor immunity. Mechanistic understanding of this two-way immune cross-talk could provide insights into novel strategies for designing better immunotherapy approaches against cancer and other diseases that normally defy immune control.

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Titel: Cooperativity of adaptive and innate immunity: implications for cancer therapy
verfasst von: Anil Shanker
Francesco M. Marincola
Publikationsdatum: 01.08.2011
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 8/2011
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-011-1053-z

Springer Medizin

Cooperativity of adaptive and innate immunity: implications for cancer therapy

Abstract

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Springer Medizin

Abstract

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