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Cancer Immunology, Immunotherapy

Erschienen in:

01.05.2013 | Focussed Research Review

Personalized peptide vaccination: a new approach for advanced cancer as therapeutic cancer vaccine

verfasst von: Masanori Noguchi, Tetsuro Sasada, Kyogo Itoh

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 5/2013

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Abstract

Since both tumor cells and host immune cell repertoires are diverse and heterogeneous, immune responses against tumor-associated antigens should differ substantially among individual cancer patients. Selection of suitable peptide vaccines for individual patients based on the preexisting host immunity before vaccination could induce potent anti-tumor responses that provide clinical benefit to cancer patients. We have developed a novel immunotherapeutic approach of personalized peptide vaccination (PPV) in which a maximum of four human leukocyte antigen (HLA) class IA-matched peptides are selected for vaccination among pooled peptides on the basis of both HLA class IA type and the preexisting host immunity before vaccination. In this review, we discuss our recent results of preclinical and clinical studies of PPV for various types of advanced cancer.

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Titel: Personalized peptide vaccination: a new approach for advanced cancer as therapeutic cancer vaccine
verfasst von: Masanori Noguchi
Tetsuro Sasada
Kyogo Itoh
Publikationsdatum: 01.05.2013
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 5/2013
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-012-1379-1

Springer Medizin

Personalized peptide vaccination: a new approach for advanced cancer as therapeutic cancer vaccine

Abstract

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Springer Medizin

Abstract

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