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International Orthopaedics

Erschienen in:

01.04.2009 | Original Paper

A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone

verfasst von: Yanlin Li, Rui Han, Chengkui Geng, Yongnian Wang, Lei Wei

Erschienen in: International Orthopaedics | Ausgabe 2/2009

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Abstract

The objective of this research was to induce a new animal model of osteonecrosis of the femoral head (ONFH) by microwave heating and then repair with tissue engineered bone. The bilateral femoral heads of 84 rabbits were heated by microwave at various temperatures. Tissue engineered bone was used to repair the osteonecrosis of femoral heads induced by microwave heating. The roentgenographic and histological examinations were used to evaluate the results. The femoral heads heated at 55°C for ten minutes showed low density and cystic changes in X-ray photographs, osteonecrosis and repair occurred simultaneously in histology at four and eight weeks, and 69% femoral heads collapsed at 12 weeks. The ability of tissue engineered bone to repair the osteonecrosis was close to that of cancellous bone autograft. The new animal model of ONFH could be induced by microwave heating, and the tissue engineering technique will provide an effective treatment.

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Titel: A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone
verfasst von: Yanlin Li
Rui Han
Chengkui Geng
Yongnian Wang
Lei Wei
Publikationsdatum: 01.04.2009
Verlag: Springer-Verlag
Erschienen in: International Orthopaedics / Ausgabe 2/2009
Print ISSN: 0341-2695
Elektronische ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-008-0672-2

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