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International Orthopaedics

Erschienen in:

01.09.2011 | Original Paper

Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck Disease (KBD) patients

verfasst von: Rui Luo, Gang Liu, Wei Liu, Fuxing Pei, Zongke Zhou, Jian Li, Bin Shen, Pengde Kang, Qibing Xie, Xin Ma

Erschienen in: International Orthopaedics | Ausgabe 9/2011

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Abstract

The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease. Adults (n = 168) with Kashin-Beck disease were randomised in clusters to receive six week courses of celecoxib 200 mg once daily, meloxicam 7.5 mg once daily or paracetamol 300 mg three times daily. Efficacy assessments included overall joint pain intensity and Western Ontario and McMaster Universities Osteoarthritis Index subscales; tolerability was evaluated by adverse event and physician reporting. Celecoxib and meloxicam were efficacious in relieving pain and improving stiffness, but unable to improve physical function after six weeks. Paracetamol was efficacious in relieving pain, but unable to improve morning stiffness and physical function after six weeks. Celecoxib and meloxicam provide predictable and sustained relief from pain and stiffness. Paracetamol can relieve the pain. None of the treatments improved impaired physical function in Kashin-Beck disease.

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Titel: Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck Disease (KBD) patients
verfasst von: Rui Luo
Gang Liu
Wei Liu
Fuxing Pei
Zongke Zhou
Jian Li
Bin Shen
Pengde Kang
Qibing Xie
Xin Ma
Publikationsdatum: 01.09.2011
Verlag: Springer-Verlag
Erschienen in: International Orthopaedics / Ausgabe 9/2011
Print ISSN: 0341-2695
Elektronische ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-010-1062-0

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