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01.11.2008 | Original Article

Increase levels of apo-A1 and apo B are associated in knee osteoarthritis: lack of association with VEGF-460 T/C and +405 C/G polymorphisms

verfasst von: Sergio Sánchez-Enríquez, Nora Magdalena Torres-Carrillo, Mónica Vázquez-Del Mercado, Lorenzo Salgado-Goytia, Héctor Rangel-Villalobos, José Francisco Muñoz-Valle

Erschienen in: Rheumatology International | Ausgabe 1/2008

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Abstract

To investigate the genotype and allele frequency of vascular endothelial growth factor gene polymorphisms in knee osteoarthritis (OA) and their relationship with disease activity and lipid profile, we enrolled 49 knee OA patients and 75 healthy subjects (HS) as a control group. Body mass index (BMI), laboratorial assessment and genotyped by polymerase chain reaction–restriction fragment length polymorphisms (PCR–RFLP) were studied in both groups. Disease activity was determined using Lequesne and WOMAC indexes; a P value < 0.05 was considered significant. The −460 and +405 VEGF polymorphisms did not shown significant association between OA patients and HS. However, between OA patients and HS a significant differences were observed in BMI, age, apo A-I and apo B, independently of both polymorphisms studied (P < 0.05). In conclusion, increased apo A-1 and apo B levels are associated in knee OA, but the −460 T/C and +405 C/G VEGF polymorphisms are not associated with knee OA susceptibility.

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Titel: Increase levels of apo-A1 and apo B are associated in knee osteoarthritis: lack of association with VEGF-460 T/C and +405 C/G polymorphisms
verfasst von: Sergio Sánchez-Enríquez
Nora Magdalena Torres-Carrillo
Mónica Vázquez-Del Mercado
Lorenzo Salgado-Goytia
Héctor Rangel-Villalobos
José Francisco Muñoz-Valle
Publikationsdatum: 01.11.2008
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 1/2008
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-008-0633-5

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