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Erschienen in: Rheumatology International 5/2010

01.03.2010 | Case Report

Werner’s syndrome: a quite rare disease for differential diagnosis of scleroderma

verfasst von: Cemal Bes, Şeref Vardı, Melih Güven, Mehmet Soy

Erschienen in: Rheumatology International | Ausgabe 5/2010

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Abstract

Werner’s syndrome (WS) is an autosomal recessive disorder characterized by premature aging. The main features of the disease are scleroderma-like skin appearance, premature atherosclerosis, short stature, diabetes mellitus, early osteoporosis and early aging. Herein, we describe a patient with WS, who has scleroderma-like skin changes and discuss the literature about WS as a disease in the differential diagnosis of systemic sclerosis.
Literatur
1.
Zurück zum Zitat Cohen BA (2008) Other genodermatoses. Premature aging syndromes and pokilodermas. In: Bolognia JL, Jorizzo JL, Rapini RP (eds) Dermatology, 2nd edn. Mosby, St Louis, pp 868–874 Cohen BA (2008) Other genodermatoses. Premature aging syndromes and pokilodermas. In: Bolognia JL, Jorizzo JL, Rapini RP (eds) Dermatology, 2nd edn. Mosby, St Louis, pp 868–874
7.
Zurück zum Zitat Goto M, Takeuchi F, Tanimoto K, Miyamoto T (1985) Clinical, demographic, and genetic aspects of the Werner syndrome in Japan. Adv Exp Med Biol 190:245–261PubMed Goto M, Takeuchi F, Tanimoto K, Miyamoto T (1985) Clinical, demographic, and genetic aspects of the Werner syndrome in Japan. Adv Exp Med Biol 190:245–261PubMed
8.
Zurück zum Zitat Chen L, Lee L, Kudlow BA, Dos Santos HG, Sletvold O, Shafeghati Y, Botha EG, Garg A, Hanson NB, Martin GM, Mian IS, Kennedy BK, Oshima J (2003) LMNA mutations in atypical Werner’s syndrome. Lancet 362(9382):440–445. doi:10.1016/S0140-6736(03)14069-X CrossRefPubMed Chen L, Lee L, Kudlow BA, Dos Santos HG, Sletvold O, Shafeghati Y, Botha EG, Garg A, Hanson NB, Martin GM, Mian IS, Kennedy BK, Oshima J (2003) LMNA mutations in atypical Werner’s syndrome. Lancet 362(9382):440–445. doi:10.​1016/​S0140-6736(03)14069-X CrossRefPubMed
11.
Zurück zum Zitat Epstein CJ, Martin GM, Schultz AL, Motulsky AG (1966) Werner’s syndrome: a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltimore) 45(3):177–221 Epstein CJ, Martin GM, Schultz AL, Motulsky AG (1966) Werner’s syndrome: a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltimore) 45(3):177–221
12.
Zurück zum Zitat Goto M (2000) Werner’s syndrome: from clinics to genetics. Clin Exp Rheumatol 18(6):760–766PubMed Goto M (2000) Werner’s syndrome: from clinics to genetics. Clin Exp Rheumatol 18(6):760–766PubMed
14.
Zurück zum Zitat Hettema ME, Zhang D, de Leeuw K, Stienstra Y, Smit AJ, Kallenberg CG, Bootsma H (2008) Early atherosclerosis in systemic sclerosis and its relation to disease or traditional risk factors. Arthritis Res Ther 10(2):R49. doi:10.1186/ar2408 CrossRefPubMed Hettema ME, Zhang D, de Leeuw K, Stienstra Y, Smit AJ, Kallenberg CG, Bootsma H (2008) Early atherosclerosis in systemic sclerosis and its relation to disease or traditional risk factors. Arthritis Res Ther 10(2):R49. doi:10.​1186/​ar2408 CrossRefPubMed
15.
Zurück zum Zitat Hinchcliff M, Varga J (2008) Systemic sclerosis/scleroderma: a treatable multisystem disease. Am Fam Physician 78(8):961–968PubMed Hinchcliff M, Varga J (2008) Systemic sclerosis/scleroderma: a treatable multisystem disease. Am Fam Physician 78(8):961–968PubMed
16.
Zurück zum Zitat Korn JH, Mayes M, Matucci Cerinic M, Rainisio M, Pope J, Hachulla E et al (2004) Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. Arthritis Rheum 50:3985–3993. doi:10.1002/art.20676 CrossRefPubMed Korn JH, Mayes M, Matucci Cerinic M, Rainisio M, Pope J, Hachulla E et al (2004) Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. Arthritis Rheum 50:3985–3993. doi:10.​1002/​art.​20676 CrossRefPubMed
Metadaten
Titel
Werner’s syndrome: a quite rare disease for differential diagnosis of scleroderma
verfasst von
Cemal Bes
Şeref Vardı
Melih Güven
Mehmet Soy
Publikationsdatum
01.03.2010
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 5/2010
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-009-0982-8

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