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Rheumatology International

Erschienen in:

01.04.2013 | Review

Regeneration of articular cartilage of the knee

verfasst von: E. Carlos Rodriguez-Merchan

Erschienen in: Rheumatology International | Ausgabe 4/2013

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Abstract

Cartilage therapy for focal articular lesions of the knee has been implemented for more than a decade, and it is becoming increasingly available. What do we know on the healing response of cartilage lesions? What do we know on the treatment of focal cartilage lesions of the knee and the prognostic factors involved? PubMed articles related to articular cartilage regeneration of the knee in clinical studies were searched from January 2006 to November 2012, using the following key words: articular cartilage, regeneration, clinical studies, and knee. A total of 44 reports were found. They showed the following possibilities for the treatment of focal lesions of the articular cartilage of the knee: cartilage regeneration and repair including cartilage reparation with gene-activated matrices, autologous chondrocyte implantation (ACI) and matrix-induced ACI (MACI), microfracture, osteochondral autograft transfer (mosaicplasty), biological approaches (scaffolds, mesenchymal stem cells—MSCs, platelet-rich plasma, growing factors—GF, bone morphogenetic proteins—BMPs, magnetically labeled synovium-derived cells—M-SDCs, and elastic-like polypeptide gels), osteotomies, stem-cell-coated titanium implants, and chondroprotection with pulsed electromagnetic fields. Untreated cartilage lesions on the femoral condyles had a superior healing response compared to those on the tibial plateaus, and in the patellofemoral joint. Clinical outcome regarding the treatment of medial defects is better than that of the lateral defects. Improvement from baseline was better for patients < or = 30 years compared with patients > or = 30 years. ACI, MACI, and mosaicplasty have shown similar results. The results of comparative clinical studies using ACI have shown some superiority over conventional microfracturing in medium or large defects and in long-term durability. Some biological methods such as scaffolds, MSCs, GF, M-SDCs, BMPs, and elastic-like polypeptide gels still need more research.

de Windt TS, Bekkers JE, Creemers LB, Dhert WJ, Saris DB (2009) Patient profiling in cartilage regeneration: prognostic factors determining success of treatment for cartilage defects. Am J Sports Med 37(Suppl 1):58S–62SPubMedCrossRef

Rodeo SA, Delos D, Weber A, Ju X, Cunningham ME, Fortier L, Maher S (2010) What’s new in orthopaedic research. J Bone Jt Surg Am 92:2491–2501CrossRef

van Osch GJ, Brittberg M, Dennis JE, Bastiaansen-Jenniskens YM, Erben RG, Konttinen YT, Luyten FP (2009) Cartilage repair: past and future—lessons for regenerative medicine. J Cell Mol Med 13:792–810PubMedCrossRef

Simon TM, Aberman HM (2010) Cartilage regeneration and repair testing in a surrogate large animal model. Tissue Eng Part B Rev 16:65–79PubMedCrossRef

Guo T, Zeng X, Hong H, Diao H, Wangrui R, Zhao J, Zhang J, Li J (2006) Gene-activated matrices for cartilage defect reparation. Int J Artif Organs 29:612–621PubMed

Nakamura N, Horibe S, Toritsuka Y, Mitsuoka T, Natsu-ume T, Yoneda K, Hamada M, Tanaka Y, Boorman RS, Yoshikawa H, Shino K (2008) The location-specific healing response of damaged articular cartilage after ACL reconstruction: short-term follow-up. Knee Surg Sports Traumatol Arthrosc 16:843–848PubMedCrossRef

Magnussen RA, Dunn WR, Carey JL, Spindler KP (2008) Treatment of focal articular cartilage defects in the knee: a systematic review. Clin Orthop Relat Res 466:952–962PubMedCrossRef

Anders S, Schaumburger J, Schubert T, Grifka J, Behrens P (2008) Matrix-associated autologous chondrocyte transplantation (MACT). Minimally invasive technique in the knee [Article in German]. Oper Orthop Traumatol 20:208–219PubMedCrossRef

Shim IK, Yook YJ, Lee SY, Lee SH, Park KD, Lee MC, Lee SJ (2008) Healing of articular cartilage defects treated with a novel drug-releasing rod-type implant after microfracture surgery. J Control Release 129:187–191PubMedCrossRef

10.

Saris DB, Vanlauwe J, Victor J, Haspl M, Bohnsack M, Fortems Y, Vandekerckhove B, Almqvist KF, Claes T, Handelberg F, Lagae K, van der Bauwhede J, Vandenneucker H, Yang KG, Jelic M, Verdonk R, Veulemans N, Bellemans J, Luyten FP (2008) Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med 36:235–246PubMedCrossRef

11.

Bae DK, Yoon KH, Song SJ (2006) Cartilage healing after microfracture in osteoarthritic knees. Arthroscopy 22:367–374PubMedCrossRef

12.

Gigante A, Enea D, Greco F, Bait C, Denti M, Schonhuber H, Volpi P (2009) Distal realignment and patellar autologous chondrocyte implantation: mid-term results in a selected population. Knee Surg Sports Traumatol Arthrosc 17:2–10PubMedCrossRef

13.

Gravius S, Schneider U, Mumme T, Bauer D, Maus U, Müller-Rath R, Berdel P, Siebert C, Andereya S (2007) Osteochondral marker proteins in the quantitative evaluation of matrix-based autologous chondrocyte transplantation CaRes (Article in German). Z Orthop Unfall 145:625–632PubMedCrossRef

14.

Stone KR, Walgenbach AW, Freyer A, Turek TJ, Speer DP (2006) Articular cartilage paste grafting to full-thickness articular cartilage knee joint lesions: a 2- to 12-year follow-up. Arthroscopy 22:291–299PubMedCrossRef

15.

Nehrer S, Domayer S, Dorotka R, Schatz K, Bindreiter U, Kotz R (2006) Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Radiol 57:3–8PubMedCrossRef

16.

Shangkai C, Naohide T, Koji Y, Yasuji H, Masaaki N, Tomohiro T, Yasushi T (2007) Transplantation of allogeneic chondrocytes cultured in fibroin sponge and stirring chamber to promote cartilage regeneration. Tissue Eng 13:483–492PubMedCrossRef

17.

Kon E, Delcogliano M, Filardo G, Pressato D, Busacca M, Grigolo B, Desando G, Marcacci M (2010) A novel nano-composite multi-layered biomaterial for treatment of osteochondral lesions: technique note and an early stability pilot clinical trial. Injury 41:693–701PubMedCrossRef

18.

Jubel A, Andermahr J, Schiffer G, Fischer J, Rehm KE, Stoddart MJ, Häuselmann HJ (2008) Transplantation of de novo scaffold-free cartilage implants into sheep knee chondral defects. Am J Sports Med 36:1555–1564PubMedCrossRef

19.

Swieszkowski W, Tuan BH, Kurzydlowski KJ, Hutmacher DW (2007) Repair and regeneration of osteochondral defects in the articular joints. Biomol Eng 24:489–495PubMedCrossRef

20.

Chang CH, Kuo TF, Lin CC, Chou CH, Chen KH, Lin FH, Liu HC (2006) Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin-chondroitin-hyaluronan tri-copolymer scaffold: a porcine model assessed at 18, 24, and 36 weeks. Biomaterials 27:1876–1888PubMedCrossRef

21.

Nugent AE, Reiter DA, Fishbein KW, McBurney DL, Murray T, Bartusik D, Ramaswamy S, Spencer RG, Horton WE Jr (2010) Characterization of ex vivo-generated bovine and human cartilage by immunohistochemical, biochemical, and magnetic resonance imaging analyses. Tissue Eng Part A 16:2183–2196PubMedCrossRef

22.

Agung M, Ochi M, Yanada S, Adachi N, Izuta Y, Yamasaki T, Toda K (2006) Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration. Knee Surg Sports Traumatol Arthrosc 14:1307–1314PubMedCrossRef

23.

Filardo G, Kon E, Buda R, Timoncini A, Di Martino A, Cenacchi A, Fornasari PM, Giannini S, Marcacci M (2011) Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc 19:528–535PubMedCrossRef

24.

Kon E, Buda R, Filardo G, Di Martino A, Timoncini A, Cenacchi A, Fornasari PM, Giannini S, Marcacci M (2010) Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc 18:472–479PubMedCrossRef

25.

Noh MJ, Copeland RO, Yi Y, Choi KB, Meschter C, Hwang S, Lim CL, Yip V, Hyun JP, Lee HY, Lee KH (2010) Pre-clinical studies of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 (TG-C). Cytotherapy 12:384–393PubMedCrossRef

26.

Schmal H, Niemeyer P, Zwingmann J, Stoffel F, Südkamp NP, Mehlhorn AT (2010) Association between expression of the bone morphogenetic proteins 2 and 7 in the repair of circumscribed cartilage lesions with clinical outcome. BMC Musculoskelet Disord 11:170PubMedCrossRef

27.

Hori J, Deie M, Kobayashi T, Yasunaga Y, Kawamata S, Ochi M (2011) Articular cartilage repair using an intra-articular magnet and synovium-derived cells. J Orthop Res 29:531–538PubMedCrossRef

28.

Nettles DL, Kitaoka K, Hanson NA, Flahiff CM, Mata BA, Hsu EW, Chilkoti A, Setton LA (2008) In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model. Tissue Eng Part A 14:1133–1140PubMedCrossRef

29.

Takeuchi R, Aratake M, Bito H, Saito I, Kumagai K, Hayashi R, Sasaki Y, Akamatsu Y, Ishikawa H, Amakado E, Aota Y, Saito T (2009) Clinical results and radiographical evaluation of opening wedge high tibial osteotomy for spontaneous osteonecrosis of the knee. Knee Surg Sports Traumatol Arthrosc 17:361–368PubMedCrossRef

30.

Yercan H, Aydoğdu S, Sur H (2007) Osteotomies in the treatment of osteochondral lesions of the knee joint (Article in Turkish). Acta Orthop Traumatol Turc 41(Suppl 2):147–152PubMed

31.

Frosch KH, Drengk A, Krause P, Viereck V, Miosge N, Werner C, Schild D, Stürmer EK, Stürmer KM (2006) Stem cell-coated titanium implants for the partial joint resurfacing of the knee. Biomaterials 27:2542–2549PubMedCrossRef

32.

Zorzi C, Dall’Oca C, Cadossi R, Setti S (2007) Effects of pulsed electromagnetic fields on patients’ recovery after arthroscopic surgery: prospective, randomized and double-blind study. Knee Surg Sports Traumatol Arthrosc 15:830–834PubMedCrossRef

33.

Grässel S, Anders S (2012) Cell-based therapy options for osteochondral defects. Autologous mesenchymal stem cells compared to autologous chondrocytes [Article in German]. Orthopade 41:415–428PubMedCrossRef

34.

Kon E, Verdonk P, Condello V, Delcogliano M, Dhollander A, Filardo G, Pignotti E, Marcacci M (2009) Matrix-assisted autologous chondrocyte transplantation for the repair of cartilage defects of the knee: systematic clinical data review and study quality analysis. Am J Sports Med 37(Suppl 1):156S–166SPubMedCrossRef

35.

Williams RJ, Gamradt SC (2008) Articular cartilage repair using a resorbable matrix scaffold. Instr Course Lect 57:563–571PubMed

36.

Niemeyer P, Kreuz PC, Steinwachs M, Südkamp NP (2007) [Operative treatment of cartilage lesions in the knee Joint (Article in German). Sportverletz Sportschaden 21:41–50PubMedCrossRef

37.

Joseph RM (2009) Osteoarthritis of the ankle: bridging concepts in basic science with clinical care. Clin Podiatr Med Surg 26:169–184PubMedCrossRef

38.

Gobbi A, Bathan L (2009) Biological approaches for cartilage repair. J Knee Surg 22:36–44PubMedCrossRef

39.

Hettrich CM, Crawford D, Rodeo SA (2008) Cartilage repair: third-generation cell-based technologies–basic science, surgical techniques, clinical outcomes. Sports Med Arthrosc 16:230–235PubMedCrossRef

40.

Vizesi F, Oliver R, Smitham P, Gothelf T, Yu Y, Walsh WR (2007) Influence of surgical preparation on the in vivo response of osteochondral defects. Proc Inst Mech Eng H 221:489–498PubMed

41.

Bentley G, Biant LC, Vijayan S, Macmull S, Skinner JA, Carrington RW (2012) Minimum ten-year results of a prospective randomised study of autologous chondrocyte implantation versus mosaicplasty for symptomatic articular cartilage lesions of the knee. J Bone Joint Surg Br 94:504–509PubMedCrossRef

42.

Anders S, Goetz J, Schubert T, Grifka J, Schaumburger J (2012) Treatment of deep articular talus lesions by matrix associated autologous chondrocyte implantation-results at five years. Int Orthop 36:2279–2285PubMedCrossRef

43.

Clar C, Cummins E, McIntyre L, Thomas S, Lamb J, Bain L, Jobanputra P, Waugh N (2005 Dec) Clinical and cost-effectiveness of autologous chondrocyte implantation for cartilage defects in knee joints: systematic review and economic evaluation. Health Technol Assess 9(47):iii–iv, ix–x, 1–82

44.

Medical Service Advisory Committee. Matrix-induced autologous chondrocyte implantation and autologous chondrocyte implantation. Dec 2010. MSAC application 1140. Assessment report. © Commonwealth of Australia 2011. http://www.msac.gov.au/

Titel: Regeneration of articular cartilage of the knee
verfasst von: E. Carlos Rodriguez-Merchan
Publikationsdatum: 01.04.2013
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 4/2013
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-012-2601-3

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