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01.08.2011 | Topic paper

Predictive factors of recurrence and survival of upper tract urothelial carcinomas

verfasst von: Grégory Verhoest, Shahrokh F. Shariat, Thomas F. Chromecki, Jay D. Raman, Vitaly Margulis, Giacomo Novara, Christian Seitz, Mesut Remzi, Morgan Rouprêt, Douglas S. Scherr, Karim Bensalah

Erschienen in: World Journal of Urology | Ausgabe 4/2011

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Abstract

Objective

UTUCC is a rare tumor, and most reports on prognostic factors come from small single-center series. The objective of this article was to provide an updated overview of current clinical, pathological and biological prognostic factors of UTUC.

Methods

PubMed was searched for records from 2002 to 2010 using the terms “prognostic factors”, “recurrence”, “survival”, and “upper tract urothelial carcinoma”. Among identified citations, papers were selected based on their clinical relevance.

Results

Classical clinical factors that influence UTUC prognosis include age, presence of symptoms, hydronephrosis, and interval from diagnosis. Many biomarkers have shown promises to better appraise the natural course of UTUC although none is currently used in clinical practice. Stage, grade, lymph node metastases, lymphovascular invasion, tumor necrosis, and tumor architecture are strong pathological parameters. RNU is the standard treatment of localized UTUC. Both laparoscopic and open approaches seem to offer similar cancer control. Lymph node dissection increases staging accuracy and might confer a survival benefit.

Conclusion

RNU is the standard treatment for most patients with UTUC. Recent multicenter studies confirmed the prognostic value of classical prognostic parameters. Better survival prediction might be obtained with prognostic systems including clinical data and new biomarkers.

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Titel: Predictive factors of recurrence and survival of upper tract urothelial carcinomas
verfasst von: Grégory Verhoest
Shahrokh F. Shariat
Thomas F. Chromecki
Jay D. Raman
Vitaly Margulis
Giacomo Novara
Christian Seitz
Mesut Remzi
Morgan Rouprêt
Douglas S. Scherr
Karim Bensalah
Publikationsdatum: 01.08.2011
Verlag: Springer-Verlag
Erschienen in: World Journal of Urology / Ausgabe 4/2011
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-011-0710-3

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