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Erschienen in: World Journal of Urology 4/2015

01.04.2015 | Invited Review

HoLEP has come of age

verfasst von: Michael W. Vincent, Peter J. Gilling

Erschienen in: World Journal of Urology | Ausgabe 4/2015

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Abstract

Introduction

Lower urinary tract symptoms (LUTS) are a common complaint and although can be adequately managed with medication, surgery remains the mainstay of treatment. Transurethral resection has been the reference ‘gold standard’, but due to its complications and issues with larger volume prostates, many alternatives have been developed and assessed. Holmium laser enucleation of the prostate (HoLEP) has shown excellent efficacy, durability and safety and has become an important alternative that has gained guideline approval.

Results

HoLEP has been shown to have outcomes that are equivalent or better than TURP in both urodynamic measurements and symptom scores. Its outcomes have been proven to be durable and cost-effective. HoLEP has fewer and less serious complications when compared to the current reference standard, its use also allows earlier removal of catheter and hospital discharge. Appropriate mentoring reduces many of the issues associated with the steep learning curve, thus removing the main hurdle to its widespread adoption as the surgical treatment of choice for LUTS due to benign prostatic hyperplasia (BPH).

Conclusions

HoLEP fulfils all of the requirements as an alternative/replacement for TURP and open prostatectomy, with equivalent outcomes and reduced complications. With improvements in the learning curve, it could now be considered the true gold standard surgical treatment for BPH. HoLEP has come of age.
Literatur
1.
Zurück zum Zitat Chute CP, Girman CJ, Oesterling JE, Guess HA, Jacobsen SJ, Leiber MM (1993) The prevalence of prostatism: a population based survey of urinary symptoms. J Urol 150(1):85–89PubMed Chute CP, Girman CJ, Oesterling JE, Guess HA, Jacobsen SJ, Leiber MM (1993) The prevalence of prostatism: a population based survey of urinary symptoms. J Urol 150(1):85–89PubMed
2.
Zurück zum Zitat Roberts OJ, Jacobson SJ, Rhodes T, Girman CJ, Lieber MM (2000) Longitudinal changes in peak urinary flow rates in a community based cohort. J Urol 163:107–113CrossRefPubMed Roberts OJ, Jacobson SJ, Rhodes T, Girman CJ, Lieber MM (2000) Longitudinal changes in peak urinary flow rates in a community based cohort. J Urol 163:107–113CrossRefPubMed
3.
Zurück zum Zitat Fraundorfer MR, Gilling PJ (1998) Holmium: YAG laser enucleation of the prostate combined with mechanical morcellation: preliminary results. Eur Urol 33(1):69–72CrossRefPubMed Fraundorfer MR, Gilling PJ (1998) Holmium: YAG laser enucleation of the prostate combined with mechanical morcellation: preliminary results. Eur Urol 33(1):69–72CrossRefPubMed
4.
5.
Zurück zum Zitat Tan A et al (2007) Meta-analysis of holmium laser enucleation versus transurethral resection of the prostate for symptomatic prostatic obstruction. Br J Surg 94(10):1201–1208CrossRefPubMed Tan A et al (2007) Meta-analysis of holmium laser enucleation versus transurethral resection of the prostate for symptomatic prostatic obstruction. Br J Surg 94(10):1201–1208CrossRefPubMed
6.
Zurück zum Zitat Tan AH et al (2003) A randomized trial comparing holmium laser enucleation of the prostate with transurethral resection of the prostate for the treatment of bladder outlet obstruction secondary to benign prostatic hyperplasia in large glands (40 to 200 grams). J Urol 170(4 Pt 1):1270–1274CrossRefPubMed Tan AH et al (2003) A randomized trial comparing holmium laser enucleation of the prostate with transurethral resection of the prostate for the treatment of bladder outlet obstruction secondary to benign prostatic hyperplasia in large glands (40 to 200 grams). J Urol 170(4 Pt 1):1270–1274CrossRefPubMed
7.
Zurück zum Zitat Kuntz RM et al (2004) Transurethral holmium laser enucleation of the prostate versus transurethral electrocautery resection of the prostate: a randomized prospective trial in 200 patients. J Urol 172(3):1012–1016CrossRefPubMed Kuntz RM et al (2004) Transurethral holmium laser enucleation of the prostate versus transurethral electrocautery resection of the prostate: a randomized prospective trial in 200 patients. J Urol 172(3):1012–1016CrossRefPubMed
8.
Zurück zum Zitat Rigatti L et al (2006) Urodynamics after TURP and HoLEP in urodynamically obstructed patients: are there any differences at 1 year of follow-up? Urology 67(6):1193–1198CrossRefPubMed Rigatti L et al (2006) Urodynamics after TURP and HoLEP in urodynamically obstructed patients: are there any differences at 1 year of follow-up? Urology 67(6):1193–1198CrossRefPubMed
9.
Zurück zum Zitat Shishido T et al (2008) Comparison of clinical results between TUR-P and holmium laser enucleation of the prostate (HoLEP) based on the initial experience. Nihon Hinyokika Gakkai Zasshi 99(3):543–550PubMed Shishido T et al (2008) Comparison of clinical results between TUR-P and holmium laser enucleation of the prostate (HoLEP) based on the initial experience. Nihon Hinyokika Gakkai Zasshi 99(3):543–550PubMed
10.
Zurück zum Zitat Kuntz RM, Lehrich K, Ahyai S (2004) Transurethral holmium laser enucleation of the prostate compared with transvesical open prostatectomy: 18-month follow-up of a randomized trial. J Endourol 18(2):189–191CrossRefPubMed Kuntz RM, Lehrich K, Ahyai S (2004) Transurethral holmium laser enucleation of the prostate compared with transvesical open prostatectomy: 18-month follow-up of a randomized trial. J Endourol 18(2):189–191CrossRefPubMed
11.
Zurück zum Zitat Fayad AS et al (2011) Holmium laser enucleation versus bipolar resection of the prostate: a prospective randomized study. which to choose? J Endourol 25(8):1347–1352CrossRefPubMed Fayad AS et al (2011) Holmium laser enucleation versus bipolar resection of the prostate: a prospective randomized study. which to choose? J Endourol 25(8):1347–1352CrossRefPubMed
12.
Zurück zum Zitat Elmansy H et al (2012) Holmium laser enucleation versus photoselective vaporization for prostatic adenoma greater than 60 ml: preliminary results of a prospective, randomized clinical trial. J Urol 188(1):216–221CrossRefPubMed Elmansy H et al (2012) Holmium laser enucleation versus photoselective vaporization for prostatic adenoma greater than 60 ml: preliminary results of a prospective, randomized clinical trial. J Urol 188(1):216–221CrossRefPubMed
13.
Zurück zum Zitat Chen YB et al (2013) A prospective, randomized clinical trial comparing plasmakinetic resection of the prostate with holmium laser enucleation of the prostate based on a 2-year followup. J Urol 189(1):217–222CrossRefPubMed Chen YB et al (2013) A prospective, randomized clinical trial comparing plasmakinetic resection of the prostate with holmium laser enucleation of the prostate based on a 2-year followup. J Urol 189(1):217–222CrossRefPubMed
14.
Zurück zum Zitat Madersbacher S et al (2005) Reoperation, myocardial infarction and mortality after transurethral and open prostatectomy: a nation-wide, long-term analysis of 23,123 cases. Eur Urol 47(4):499–504CrossRefPubMed Madersbacher S et al (2005) Reoperation, myocardial infarction and mortality after transurethral and open prostatectomy: a nation-wide, long-term analysis of 23,123 cases. Eur Urol 47(4):499–504CrossRefPubMed
15.
Zurück zum Zitat Ahyai SA et al (2010) Meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic enlargement. Eur Urol 58(3):384–397CrossRefPubMed Ahyai SA et al (2010) Meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic enlargement. Eur Urol 58(3):384–397CrossRefPubMed
16.
Zurück zum Zitat Krambeck AE, Handa SE, Lingeman JE (2010) Experience with more than 1,000 holmium laser prostate enucleations for benign prostatic hyperplasia. J Urol 183(3):1105–1109CrossRefPubMed Krambeck AE, Handa SE, Lingeman JE (2010) Experience with more than 1,000 holmium laser prostate enucleations for benign prostatic hyperplasia. J Urol 183(3):1105–1109CrossRefPubMed
17.
Zurück zum Zitat Elmansy HM, Kotb A, Elhilali MM (2011) Holmium laser enucleation of the prostate: long-term durability of clinical outcomes and complication rates during 10 years of followup. J Urol 186(5):1972–1976CrossRefPubMed Elmansy HM, Kotb A, Elhilali MM (2011) Holmium laser enucleation of the prostate: long-term durability of clinical outcomes and complication rates during 10 years of followup. J Urol 186(5):1972–1976CrossRefPubMed
18.
Zurück zum Zitat Gilling PJ et al (2012) Long-term results of a randomized trial comparing holmium laser enucleation of the prostate and transurethral resection of the prostate: results at 7 years. BJU Int 109(3):408–411CrossRefPubMed Gilling PJ et al (2012) Long-term results of a randomized trial comparing holmium laser enucleation of the prostate and transurethral resection of the prostate: results at 7 years. BJU Int 109(3):408–411CrossRefPubMed
19.
Zurück zum Zitat Ahyai SA et al (2012) Transurethral holmium laser enucleation versus transurethral resection of the prostate and simple open prostatectomy—which procedure is faster? J Urol 187(5):1608–1613CrossRefPubMed Ahyai SA et al (2012) Transurethral holmium laser enucleation versus transurethral resection of the prostate and simple open prostatectomy—which procedure is faster? J Urol 187(5):1608–1613CrossRefPubMed
20.
Zurück zum Zitat Fraundorfer MR et al (2001) Holmium laser resection of the prostate is more cost effective than transurethral resection of the prostate: results of a randomized prospective study. Urology 57(3):454–458CrossRefPubMed Fraundorfer MR et al (2001) Holmium laser resection of the prostate is more cost effective than transurethral resection of the prostate: results of a randomized prospective study. Urology 57(3):454–458CrossRefPubMed
21.
Zurück zum Zitat Salonia A et al (2006) Holmium laser enucleation versus open prostatectomy for benign prostatic hyperplasia: an inpatient cost analysis. Urology 68(2):302–306CrossRefPubMed Salonia A et al (2006) Holmium laser enucleation versus open prostatectomy for benign prostatic hyperplasia: an inpatient cost analysis. Urology 68(2):302–306CrossRefPubMed
23.
Zurück zum Zitat Elshal AM, Elkoushy MA, Elmansy HM, Sampalis J, Elhilali MM (2014) Holmium: YAG transurethral incision versus laser photoselective vaporization for benign prostatic hyperplasia in a small prostate. J urol 191(1):148–154CrossRefPubMed Elshal AM, Elkoushy MA, Elmansy HM, Sampalis J, Elhilali MM (2014) Holmium: YAG transurethral incision versus laser photoselective vaporization for benign prostatic hyperplasia in a small prostate. J urol 191(1):148–154CrossRefPubMed
24.
Zurück zum Zitat Shao Q et al (2009) Comparison of holmium and thulium laser in transurethral enucleation of the prostate. 1009–3591 (print) Shao Q et al (2009) Comparison of holmium and thulium laser in transurethral enucleation of the prostate. 1009–3591 (print)
25.
Zurück zum Zitat Kuntz RM, Lehrich K, Ahyai SA (2008) Holmium laser enucleation of the prostate versus open prostatectomy for prostates greater than 100 grams: 5-year follow-up results of a randomised clinical trial. Eur Urol 53(1):160–166CrossRefPubMed Kuntz RM, Lehrich K, Ahyai SA (2008) Holmium laser enucleation of the prostate versus open prostatectomy for prostates greater than 100 grams: 5-year follow-up results of a randomised clinical trial. Eur Urol 53(1):160–166CrossRefPubMed
26.
Zurück zum Zitat Bapat S et al (2007) Comparison of fluid absorption during transurethral resection of prostate and Holmium-Yag laser enucleation of benign adenoma of prostate using breath ethanol concentration. Indian J Urol 23(2):126–129CrossRefPubMedCentralPubMed Bapat S et al (2007) Comparison of fluid absorption during transurethral resection of prostate and Holmium-Yag laser enucleation of benign adenoma of prostate using breath ethanol concentration. Indian J Urol 23(2):126–129CrossRefPubMedCentralPubMed
27.
Zurück zum Zitat Tyson MD, Lerner LB (2009) Safety of holmium laser enucleation of the prostate in anticoagulated patients. J Endourol 23(8):1343–1346CrossRefPubMed Tyson MD, Lerner LB (2009) Safety of holmium laser enucleation of the prostate in anticoagulated patients. J Endourol 23(8):1343–1346CrossRefPubMed
28.
Zurück zum Zitat Elzayat EA, Elhilali MM (2007) Holmium laser enucleation of the prostate (HoLEP): long-term results, reoperation rate, and possible impact of the learning curve. Eur Urol 52(5):1465–1471CrossRefPubMed Elzayat EA, Elhilali MM (2007) Holmium laser enucleation of the prostate (HoLEP): long-term results, reoperation rate, and possible impact of the learning curve. Eur Urol 52(5):1465–1471CrossRefPubMed
29.
Zurück zum Zitat Placer J et al (2009) Holmium laser enucleation of prostate: outcome and complications of self-taught learning curve. Urology 73(5):1042–1048CrossRefPubMed Placer J et al (2009) Holmium laser enucleation of prostate: outcome and complications of self-taught learning curve. Urology 73(5):1042–1048CrossRefPubMed
30.
Zurück zum Zitat Aho TF et al (2005) Holmium laser bladder neck incision versus holmium enucleation of the prostate as outpatient procedures for prostates less than 40 grams: a randomized trial. J Urol 174(1):210–214CrossRefPubMed Aho TF et al (2005) Holmium laser bladder neck incision versus holmium enucleation of the prostate as outpatient procedures for prostates less than 40 grams: a randomized trial. J Urol 174(1):210–214CrossRefPubMed
31.
Zurück zum Zitat Bae J, Oh SJ, Paick JS (2010) The learning curve for holmium laser enucleation of the prostate: a single-center experience. Korean J Urol 51(10):688–693CrossRefPubMedCentralPubMed Bae J, Oh SJ, Paick JS (2010) The learning curve for holmium laser enucleation of the prostate: a single-center experience. Korean J Urol 51(10):688–693CrossRefPubMedCentralPubMed
32.
Zurück zum Zitat Hirayama T et al (2010) An effective method to shorten the learning curve of HoLEP. Hinyokika Kiyo 56(8):431–434PubMed Hirayama T et al (2010) An effective method to shorten the learning curve of HoLEP. Hinyokika Kiyo 56(8):431–434PubMed
Metadaten
Titel
HoLEP has come of age
verfasst von
Michael W. Vincent
Peter J. Gilling
Publikationsdatum
01.04.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
World Journal of Urology / Ausgabe 4/2015
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-014-1443-x

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