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23.10.2015 | Invited Review

Clinical significance of residual fragments in 2015: impact, detection, and how to avoid them

verfasst von: Simon Hein, Arkadiusz Miernik, Konrad Wilhelm, Fabian Adams, Daniel Schlager, Thomas R. W. Herrmann, Jens J. Rassweiler, Martin Schoenthaler

Erschienen in: World Journal of Urology | Ausgabe 6/2016

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Abstract

Purpose

Residual fragments are common after stone treatment. Little is known about clinical outcomes relevant to the patient. This comprehensive review of the literature highlights the impact of residual fragments, modes of detection, and treatment strategies to avoid residual fragments in shock wave therapy, ureteroscopy, and percutaneous nephrolithotomy.

Methods

A comprehensive review of current literature was performed using PubMed^®, MEDLINE^®, Embase™, Ovid^®, Google Scholar™, and the Cochrane Library. Publications relevant to the subject were retrieved and critically appraised.

Results

Residual fragments after treatment for urinary stones have a significant impact on a patient’s well-being and future course. (Ultra-) low-dose non-contrast computed tomography detects small residuals most reliably. In shock wave lithotripsy, adherence to basic principles helps to improve results. Various techniques and devices facilitate complete stone clearance in conventional and miniaturized percutaneous nephrolithotomy and (flexible) ureteroscopy. Promising new technologies in shock waves, lasers, and robotics (and potentially microrobotics) are on the horizon.

Conclusions

Residual fragments are relevant to patients. Contemporary treatment of urolithiasis should aim at complete stone clearance.

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Altunrende F, Tefekli A, Stein RJ, Autorino R, Yuruk E, Laydner H, Binbay M, Muslumanoglu AY (2011) Clinically insignificant residual fragments after percutaneous nephrolithotomy: medium-term follow-up. J Endourol/Endourol Soc 25(6):941–945. doi:10.1089/end.2010.0491 CrossRef

Osman MM, Alfano Y, Kamp S, Haecker A, Alken P, Michel MS, Knoll T (2005) 5-year-follow-up of patients with clinically insignificant residual fragments after extracorporeal shockwave lithotripsy. Eur Urol 47(6):860–864. doi:10.1016/j.eururo.2005.01.005 CrossRefPubMed

Rassweiler JJ, Renner C, Chaussy C, Thuroff S (2001) Treatment of renal stones by extracorporeal shockwave lithotripsy: an update. Eur Urol 39(2):187–199CrossRefPubMed

Ozgor F, Simsek A, Binbay M, Akman T, Kucuktopcu O, Sarilar O, Muslumanoglu AY, Berberoglu Y (2014) Clinically insignificant residual fragments after flexible ureterorenoscopy: medium-term follow-up results. Urolithiasis 42(6):533–538. doi:10.1007/s00240-014-0691-y CrossRefPubMed

Tan YH, Wong M (2005) How significant are clinically insignificant residual fragments following lithotripsy? Curr Opin Urol 15(2):127–131CrossRefPubMed

El-Nahas AR, El-Assmy AM, Madbouly K, Sheir KZ (2006) Predictors of clinical significance of residual fragments after extracorporeal shockwave lithotripsy for renal stones. J Endourol/Endourol Soc 20(11):870–874. doi:10.1089/end.2006.20.870 CrossRef

Khaitan A, Gupta NP, Hemal AK, Dogra PN, Seth A, Aron M (2002) Post-ESWL, clinically insignificant residual stones: reality or myth? Urology 59(1):20–24CrossRefPubMed

Raman JD, Bagrodia A, Gupta A, Bensalah K, Cadeddu JA, Lotan Y, Pearle MS (2009) Natural history of residual fragments following percutaneous nephrostolithotomy. J Urol 181(3):1163–1168. doi:10.1016/j.juro.2008.10.162 CrossRefPubMed

Ganpule A, Desai M (2009) Fate of residual stones after percutaneous nephrolithotomy: a critical analysis. J Endourol/Endourol Soc 23(3):399–403. doi:10.1089/end.2008.0217 CrossRef

10.

Rebuck DA, Macejko A, Bhalani V, Ramos P, Nadler RB (2011) The natural history of renal stone fragments following ureteroscopy. Urology 77(3):564–568. doi:10.1016/j.urology.2010.06.056 CrossRefPubMed

11.

Denstedt JD, Clayman RV, Picus DD (1991) Comparison of endoscopic and radiological residual fragment rate following percutaneous nephrolithotripsy. J Urol 145(4):703–705PubMed

12.

Acar C, Cal C (2012) Impact of Residual Fragments following Endourological Treatments in Renal Stones. Adv Urol 2012:813523. doi:10.1155/2012/813523 CrossRefPubMedPubMedCentral

13.

Logarakis NF, Jewett MA, Luymes J, Honey RJ (2000) Variation in clinical outcome following shock wave lithotripsy. J Urol 163(3):721–725CrossRefPubMed

14.

Türk C, Petřík A, Sarica K, Seitz C, Skolarikos A, Straub M, Knoll T (2015) EAU guidelines on interventional treatment for urolithiasis. Eur Urol. doi:10.1016/j.eururo.2015.07.041. [Epub ahead of print]

15.

Preminger GM, Tiselius HG, Assimos DG, Alken P, Buck C, Gallucci M, Knoll T, Lingeman JE, Nakada SY, Pearle MS, Sarica K, Turk C, Wolf JS Jr (2007) 2007 guideline for the management of ureteral calculi. J Urol 178(6):2418–2434. doi:10.1016/j.juro.2007.09.107 CrossRefPubMed

16.

Ray AA, Ghiculete D, Pace KT, Honey RJ (2010) Limitations to ultrasound in the detection and measurement of urinary tract calculi. Urology 76(2):295–300. doi:10.1016/j.urology.2009.12.015 CrossRefPubMed

17.

Kennish SJ, Bhatnagar P, Wah TM, Bush S, Irving HC (2008) Is the KUB radiograph redundant for investigating acute ureteric colic in the non-contrast enhanced computed tomography era? Clin Radiol 63(10):1131–1135. doi:10.1016/j.crad.2008.04.012 CrossRefPubMed

18.

Kupeli B, Gurocak S, Tunc L, Senocak C, Karaoglan U, Bozkirli I (2005) Value of ultrasonography and helical computed tomography in the diagnosis of stone-free patients after extracorporeal shock wave lithotripsy (USG and helical CT after SWL). Int Urol Nephrol 37(2):225–230. doi:10.1007/s11255-004-7975-z CrossRefPubMed

19.

Osman Y, El-Tabey N, Refai H, Elnahas A, Shoma A, Eraky I, Kenawy M, El-Kapany H (2008) Detection of residual stones after percutaneous nephrolithotomy: role of nonenhanced spiral computerized tomography. J Urol 179(1):198–200. doi:10.1016/j.juro.2007.08.175 (discussion 200) CrossRefPubMed

20.

Osman Y, Harraz AM, El-Nahas AR, Awad B, El-Tabey N, Shebel H, Shoma AM, Eraky I, El-Kenawy M (2013) Clinically insignificant residual fragments: an acceptable term in the computed tomography era? Urology 81(4):723–726. doi:10.1016/j.urology.2013.01.011 CrossRefPubMed

21.

Kluner C, Hein PA, Gralla O, Hein E, Hamm B, Romano V, Rogalla P (2006) Does ultra-low-dose CT with a radiation dose equivalent to that of KUB suffice to detect renal and ureteral calculi? J Comput Assist Tomogr 30(1):44–50CrossRefPubMed

22.

Pooler BD, Lubner MG, Kim DH, Ryckman EM, Sivalingam S, Tang J, Nakada SY, Chen GH, Pickhardt PJ (2014) Prospective trial of the detection of urolithiasis on ultralow dose (sub mSv) noncontrast computerized tomography: direct comparison against routine low dose reference standard. J Urol 192(5):1433–1439. doi:10.1016/j.juro.2014.05.089 CrossRefPubMedPubMedCentral

23.

Schmiedt E, Chaussy C (1984) Extracorporeal shock-wave lithotripsy (ESWL) of kidney and ureteric stones. Int Urol Nephrol 16(4):273–283CrossRefPubMed

24.

Eisenmenger W, Du XX, Tang C, Zhao S, Wang Y, Rong F, Dai D, Guan M, Qi A (2002) The first clinical results of “wide-focus and low-pressure” ESWL. Ultrasound Med Biol 28(6):769–774CrossRefPubMed

25.

Neisius A, Wollner J, Thomas C, Roos FC, Brenner W, Hampel C, Preminger GM, Thuroff JW, Gillitzer R (2013) Treatment efficacy and outcomes using a third generation shockwave lithotripter. BJU Int 112(7):972–981. doi:10.1111/bju.12159 CrossRefPubMed

26.

Tan YM, Yip SK, Chong TW, Wong MY, Cheng C, Foo KT (2002) Clinical experience and results of ESWL treatment for 3,093 urinary calculi with the Storz Modulith SL 20 lithotripter at the Singapore general hospital. Scand J Urol Nephrol 36(5):363–367. doi:10.1080/003655902320783872 CrossRefPubMed

27.

Madbouly K, Sheir KZ, Elsobky E, Eraky I, Kenawy M (2002) Risk factors for the formation of a steinstrasse after extracorporeal shock wave lithotripsy: a statistical model. J Urol 167(3):1239–1242CrossRefPubMed

28.

Semins MJ, Trock BJ, Matlaga BR (2008) The effect of shock wave rate on the outcome of shock wave lithotripsy: a meta-analysis. J Urol 179(1):194–197. doi:10.1016/j.juro.2007.08.173 CrossRefPubMed

29.

Tailly GG, Tailly-Cusse MM (2014) Optical coupling control: an important step toward better shockwave lithotripsy. J Endourol/Endourol Soc 28(11):1368–1373. doi:10.1089/end.2014.0338 CrossRef

30.

Jagtap J, Mishra S, Bhattu A, Ganpule A, Sabnis R, Desai M (2014) Evolution of shockwave lithotripsy (SWL) technique: a 25-year single centre experience of >5000 patients. BJU Int 114(5):748–753. doi:10.1111/bju.12808 CrossRefPubMed

31.

Lee SW, Chaiyakunapruk N, Chong HY, Liong ML (2014) Comparative effectiveness and safety of various treatment procedures for lower pole renal calculi: a systematic review and network meta-analysis. BJU Int. doi:10.1111/bju.12983

32.

de la Rosette J, Assimos D, Desai M, Gutierrez J, Lingeman J, Scarpa R, Tefekli A (2011) The Clinical Research Office of the Endourological Society Percutaneous Nephrolithotomy Global Study: indications, complications, and outcomes in 5803 patients. J Endourol/Endourol Soc 25(1):11–17. doi:10.1089/end.2010.0424 CrossRef

33.

Knoll T, Jessen JP, Honeck P, Wendt-Nordahl G (2011) Flexible ureterorenoscopy versus miniaturized PNL for solitary renal calculi of 10-30 mm size. World J Urol 29(6):755–759. doi:10.1007/s00345-011-0784-y CrossRefPubMed

34.

Leveillee RJ, Lobik L (2003) Intracorporeal lithotripsy: which modality is best? Curr Opin Urol 13(3):249–253. doi:10.1097/01.mou.0000068753.22370.47 CrossRefPubMed

35.

Bader MJ, Pongratz T, Khoder W, Stief CG, Herrmann T, Nagele U, Sroka R (2014) Impact of pulse duration on Ho:YAG laser lithotripsy: fragmentation and dusting performance. World J Urol. doi:10.1007/s00345-014-1429-8 PubMedPubMedCentral

36.

Nicklas AP, Schilling D, Bader MJ, Herrmann TR, Nagele U (2015) The vacuum cleaner effect in minimally invasive percutaneous nephrolitholapaxy. World J Urol. doi:10.1007/s00345-015-1541-4

37.

Sabnis RB, Ganesamoni R, Doshi A, Ganpule AP, Jagtap J, Desai MR (2013) Micropercutaneous nephrolithotomy (microperc) vs retrograde intrarenal surgery for the management of small renal calculi: a randomized controlled trial. BJU Int 112(3):355–361. doi:10.1111/bju.12164 CrossRefPubMed

38.

Saglam R, Muslumanoglu AY, Tokatli Z, Caskurlu T, Sarica K, Tasci AI, Erkurt B, Suer E, Kabakci AS, Preminger G, Traxer O, Rassweiler JJ (2014) A new robot for flexible ureteroscopy: development and early clinical results (IDEAL stage 1-2b). Eur Urol 66(6):1092–1100. doi:10.1016/j.eururo.2014.06.047 CrossRefPubMed

39.

Schatloff O, Lindner U, Ramon J, Winkler HZ (2010) Randomized trial of stone fragment active retrieval versus spontaneous passage during holmium laser lithotripsy for ureteral stones. J Urol 183(3):1031–1035. doi:10.1016/j.juro.2009.11.013 CrossRefPubMed

40.

John TT, Razdan S (2010) Adjunctive tamsulosin improves stone free rate after ureteroscopic lithotripsy of large renal and ureteric calculi: a prospective randomized study. Urology 75(5):1040–1042. doi:10.1016/j.urology.2009.07.1257 CrossRefPubMed

41.

Magheli A, Semins MJ, Allaf ME, Matlaga BR (2012) Critical analysis of the miniaturized stone basket: effect on deflection and flow rate. J Endourol/Endourol Soc 26(3):275–277. doi:10.1089/end.2011.0166 CrossRef

42.

Schoenthaler M, Wilhelm K, Katzenwadel A, Ardelt P, Wetterauer U, Traxer O, Miernik A (2012) Retrograde intrarenal surgery in treatment of nephrolithiasis: is a 100% stone-free rate achievable? J Endourol/Endourol Soc 26(5):489–493. doi:10.1089/end.2011.0405 CrossRef

43.

Traxer O, Thomas A (2013) Prospective evaluation and classification of ureteral wall injuries resulting from insertion of a ureteral access sheath during retrograde intrarenal surgery. J Urol 189(2):580–584. doi:10.1016/j.juro.2012.08.197 CrossRefPubMed

44.

Ursiny M, Eisner BH (2013) Cost-effectiveness of anti-retropulsion devices for ureteroscopic lithotripsy. J Urol 189(5):1762–1766. doi:10.1016/j.juro.2012.11.085 CrossRefPubMed

45.

Neisius A, Smith NB, Sankin G, Kuntz NJ, Madden JF, Fovargue DE, Mitran S, Lipkin ME, Simmons WN, Preminger GM, Zhong P (2014) Improving the lens design and performance of a contemporary electromagnetic shock wave lithotripter. Proc Natl Acad Sci USA 111(13):E1167–E1175. doi:10.1073/pnas.1319203111 CrossRefPubMedPubMedCentral

46.

Maxwell AD, Cunitz BW, Kreider W, Sapozhnikov OA, Hsi RS, Harper JD, Bailey MR, Sorensen MD (2015) Fragmentation of urinary calculi in vitro by burst wave lithotripsy. J Urol 193(1):338–344. doi:10.1016/j.juro.2014.08.009 CrossRefPubMedPubMedCentral

47.

Qiu J, Teichman JM, Wang T, Neev J, Glickman RD, Chan KF, Milner TE (2010) Femtosecond laser lithotripsy: feasibility and ablation mechanism. J Biomed Opt 15(2):028001. doi:10.1117/1.3368998 CrossRefPubMed

48.

Cloutier J, Cordeiro ER, Kamphuis GM, Villa L, Letendre J, de la Rosette JJ, Traxer O (2014) The glue-clot technique: a new technique description for small calyceal stone fragments removal. Urolithiasis 42(5):441–444. doi:10.1007/s00240-014-0679-7 CrossRefPubMed

49.

Tan YK, McLeroy SL, Faddegon S, Olweny E, Fernandez R, Beardsley H, Gnade B, Park S, Pearle MS, Cadeddu JA (2012) In vitro comparison of prototype magnetic tool with conventional nitinol basket for ureteroscopic retrieval of stone fragments rendered paramagnetic with iron oxide microparticles. J Urol 188(2):648–652. doi:10.1016/j.juro.2012.03.118 CrossRefPubMed

50.

Desai MM, Grover R, Aron M, Ganpule A, Joshi SS, Desai MR, Gill IS (2011) Robotic flexible ureteroscopy for renal calculi: initial clinical experience. J Urol 186(2):563–568. doi:10.1016/j.juro.2011.03.128 CrossRefPubMed

51.

Schamel D, Mark AG, Gibbs JG, Miksch C, Morozov KI, Leshansky AM, Fischer P (2014) Nanopropellers and their actuation in complex viscoelastic media. ACS Nano 8(9):8794–8801. doi:10.1021/nn502360t CrossRefPubMed

Titel: Clinical significance of residual fragments in 2015: impact, detection, and how to avoid them
verfasst von: Simon Hein
Arkadiusz Miernik
Konrad Wilhelm
Fabian Adams
Daniel Schlager
Thomas R. W. Herrmann
Jens J. Rassweiler
Martin Schoenthaler
Publikationsdatum: 23.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: World Journal of Urology / Ausgabe 6/2016
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-015-1713-2

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