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01.07.2006 | Original Paper

Pathological Heterogeneity of the Precentral Gyrus in Pick’s Disease: A Study of 16 Autopsy Cases

verfasst von: Kuniaki Tsuchiya, Yue-Shan Piao, Tatsuro Oda, Akihide Mochizuki, Kunimasa Arima, Kazuko Hasegawa, Chie Haga, Akiyoshi Kakita, Koji Hori, Itaru Tominaga, Saburo Yagishita, Haruhiko Akiyama, Hitoshi Takahashi

Erschienen in: Acta Neuropathologica | Ausgabe 1/2006

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Abstract

This report concerns the upper motor neuron involvement in 16 autopsy cases of Pick disease with Pick bodies, including 11 cases reported by us previously. Prominent, circumscribed atrophy of the precentral gyrus, conspicuously in the lower portion, was noted in one case. Loss of Betz cells and astrocytosis of the precentral gyrus layer V were encountered in 15 cases (94%) and eight cases (50%), respectively. Appearance of Pick bodies and ballooned neurons in the precentral gyrus layer V was confirmed in seven cases (44%). Degeneration of the pyramidal tract in the medulla oblongata was noted in all 15 cases in which this structure was examined. Pyramidal signs were observed in four (67%) of the six cases that were neurologically sufficiently examined: hyperreflexia in four cases (67%), spasticity in one case (17%). Babinski sign was not encountered in any of the six cases. In all four cases having pyramidal signs, degeneration of the pyramidal tract was observed. In contrast, two cases having degeneration of the pyramidal tract did not develop pyramidal signs. In Pick’s disease with Pick bodies, obvious involvement of the precentral gyrus and pyramidal tract was not previously noticed. Furthermore, we suggest that pyramidal signs in Pick’s disease with Pick bodies have been underestimated.

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Titel: Pathological Heterogeneity of the Precentral Gyrus in Pick’s Disease: A Study of 16 Autopsy Cases
verfasst von: Kuniaki Tsuchiya
Yue-Shan Piao
Tatsuro Oda
Akihide Mochizuki
Kunimasa Arima
Kazuko Hasegawa
Chie Haga
Akiyoshi Kakita
Koji Hori
Itaru Tominaga
Saburo Yagishita
Haruhiko Akiyama
Hitoshi Takahashi
Publikationsdatum: 01.07.2006
Verlag: Springer-Verlag
Erschienen in: Acta Neuropathologica / Ausgabe 1/2006
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-005-0028-6

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