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Erschienen in: Archives of Gynecology and Obstetrics 6/2011

01.12.2011 | Gynecologic Oncology

Relationship between endometriosis and cancer from current perspective

verfasst von: Arif Kokcu

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 6/2011

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Abstract

Purpose

To examine the current mechanisms of the increased incidence of cancer in women with endometriosis.

Methods

The synthesis and review of the relevant current literature in English language.

Results

Compared with general population, women with endometriosis have two times higher risk for developing ovarian cancer, 30% higher risk for developing breast cancer, and 40% higher risk for developing hematopoietic malignancies, mainly non-Hodgkin lymphoma.

Conclusions

Endometriosis comprises many predisposing factors including genetic, epigenetic, local environmental, hormonal, inflammatory and immunologic changes, for the development of some cancers.
Literatur
1.
Zurück zum Zitat Hudelist G, Keckstein J, Wright JT (2009) The migrating adenomyoma: past views on the etiology of adenomyosis and endometriosis. Fertil Steril 92:1536–1543PubMedCrossRef Hudelist G, Keckstein J, Wright JT (2009) The migrating adenomyoma: past views on the etiology of adenomyosis and endometriosis. Fertil Steril 92:1536–1543PubMedCrossRef
2.
Zurück zum Zitat Tariverdian N, Theoharides TC, Siedentopf F et al (2007) Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach. Semin Immunopathol 29:193–210PubMedCrossRef Tariverdian N, Theoharides TC, Siedentopf F et al (2007) Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach. Semin Immunopathol 29:193–210PubMedCrossRef
3.
Zurück zum Zitat Karanjgaokar VC, Murphy DJ, Samra JS, Mann CH (2009) Malignant transformation of residual endometriosis after hysterectomy: a case series. Fertil Steril 92:2037.e19-21PubMedCrossRef Karanjgaokar VC, Murphy DJ, Samra JS, Mann CH (2009) Malignant transformation of residual endometriosis after hysterectomy: a case series. Fertil Steril 92:2037.e19-21PubMedCrossRef
4.
Zurück zum Zitat Vlahos NF, Kalampokas T, Fotiou S (2010) Endometriosis and ovarian cancer: a review. Gynecol Endocrinol 26:213–219PubMedCrossRef Vlahos NF, Kalampokas T, Fotiou S (2010) Endometriosis and ovarian cancer: a review. Gynecol Endocrinol 26:213–219PubMedCrossRef
5.
Zurück zum Zitat Kauppila S, Altinörs M, Väre P, Liakka A, Knuuti E, Nissi R (2008) Primary sex cord-like variant of endometrioid adenocarcinoma arising from endometriosis. APMIS 116:842–845PubMedCrossRef Kauppila S, Altinörs M, Väre P, Liakka A, Knuuti E, Nissi R (2008) Primary sex cord-like variant of endometrioid adenocarcinoma arising from endometriosis. APMIS 116:842–845PubMedCrossRef
6.
Zurück zum Zitat Efthymiou CA (2009) Endometriosis-associated intestinal tumours: a consequence of long-term unopposed oestrogen? Ann R Coll Surg Engl 91:259–260PubMedCrossRef Efthymiou CA (2009) Endometriosis-associated intestinal tumours: a consequence of long-term unopposed oestrogen? Ann R Coll Surg Engl 91:259–260PubMedCrossRef
7.
Zurück zum Zitat Manipadam MT, Munemane A, Emmanuel P, McCluggage WG (2008) Ovarian adenosarcoma with extensive deciduoid morphology arising in endometriosis: a case report. Int J Gynecol Pathol 27:398–401PubMedCrossRef Manipadam MT, Munemane A, Emmanuel P, McCluggage WG (2008) Ovarian adenosarcoma with extensive deciduoid morphology arising in endometriosis: a case report. Int J Gynecol Pathol 27:398–401PubMedCrossRef
8.
Zurück zum Zitat Nagle CM, Olsen CM, Webb PM, Jordan SJ, Whiteman DC, Green AC (2008) Endometrioid and clear cell ovarian cancers: a comparative analysis of risk factors. Eur J Cancer 44:2477–2484PubMedCrossRef Nagle CM, Olsen CM, Webb PM, Jordan SJ, Whiteman DC, Green AC (2008) Endometrioid and clear cell ovarian cancers: a comparative analysis of risk factors. Eur J Cancer 44:2477–2484PubMedCrossRef
9.
Zurück zum Zitat Orezzoli JP, Russell AH, Oliva E, Del Carmen MG, Eichhorn J, Fuller AF (2008) Prognostic implication of endometriosis in clear cell carcinoma of the ovary. Gynecol Oncol 110:336–344PubMedCrossRef Orezzoli JP, Russell AH, Oliva E, Del Carmen MG, Eichhorn J, Fuller AF (2008) Prognostic implication of endometriosis in clear cell carcinoma of the ovary. Gynecol Oncol 110:336–344PubMedCrossRef
10.
Zurück zum Zitat Park HM, Lee SS, Eom DW, Kang GH, Yi SW, Sohn WS (2009) Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix: a case report. J Korean Med Sci 24:767–771PubMedCrossRef Park HM, Lee SS, Eom DW, Kang GH, Yi SW, Sohn WS (2009) Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix: a case report. J Korean Med Sci 24:767–771PubMedCrossRef
11.
Zurück zum Zitat Vlahos NF, Economopoulos KP, Fotiou S (2010) Endometriosis, in vitro fertilisation and the risk of gynaecological malignancies, including ovarian and breast cancer. Best Pract Res Clin Obstet Gynaecol 24:39–50PubMedCrossRef Vlahos NF, Economopoulos KP, Fotiou S (2010) Endometriosis, in vitro fertilisation and the risk of gynaecological malignancies, including ovarian and breast cancer. Best Pract Res Clin Obstet Gynaecol 24:39–50PubMedCrossRef
12.
Zurück zum Zitat Sznurkowski JJ, Emerich J (2008) Endometriomas are more frequent on the left side. Acta Obstet Gynecol Scand 87:104–106PubMedCrossRef Sznurkowski JJ, Emerich J (2008) Endometriomas are more frequent on the left side. Acta Obstet Gynecol Scand 87:104–106PubMedCrossRef
13.
Zurück zum Zitat Nezhat F, Datta MS, Hanson V, Pejovic T, Nezhat C, Nezhat C (2008) The relationship of endometriosis and ovarian malignancy: a review. Fertil Steril 90:1559–1570PubMedCrossRef Nezhat F, Datta MS, Hanson V, Pejovic T, Nezhat C, Nezhat C (2008) The relationship of endometriosis and ovarian malignancy: a review. Fertil Steril 90:1559–1570PubMedCrossRef
14.
Zurück zum Zitat Brinton LA, Gridley G, Persson I, Baron J, Bergqvist A (1997) Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol 176:572–579PubMedCrossRef Brinton LA, Gridley G, Persson I, Baron J, Bergqvist A (1997) Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol 176:572–579PubMedCrossRef
15.
Zurück zum Zitat Matalliotakis I, Cakmak H, Fragouli Y, Zervoudis S, Neonaki M, Arici A (2009) Association of endometriosis with family history of non-Hodgkin’s lymphoma: presentation of 10 cases. J BUON 14:699–701PubMed Matalliotakis I, Cakmak H, Fragouli Y, Zervoudis S, Neonaki M, Arici A (2009) Association of endometriosis with family history of non-Hodgkin’s lymphoma: presentation of 10 cases. J BUON 14:699–701PubMed
16.
Zurück zum Zitat Aris A (2010) Endometriosis-associated ovarian cancer: a ten-year cohort study of women living in the Estrie Region of Quebec, Canada. J Ovarian Res 3:2PubMedCrossRef Aris A (2010) Endometriosis-associated ovarian cancer: a ten-year cohort study of women living in the Estrie Region of Quebec, Canada. J Ovarian Res 3:2PubMedCrossRef
17.
Zurück zum Zitat Agrawal A, Nation J, Ghatage P, Chu P, Ross S, Magliocco A (2009) Malignant chest wall endometriosis: a case report and literature review. J Obstet Gynaecol Can 31:538–541PubMed Agrawal A, Nation J, Ghatage P, Chu P, Ross S, Magliocco A (2009) Malignant chest wall endometriosis: a case report and literature review. J Obstet Gynaecol Can 31:538–541PubMed
18.
Zurück zum Zitat Benoit L, Arnould L, Cheynel N et al (2006) Malignant extraovarian endometriosis: a review. Eur J Surg Oncol 32:6–11PubMedCrossRef Benoit L, Arnould L, Cheynel N et al (2006) Malignant extraovarian endometriosis: a review. Eur J Surg Oncol 32:6–11PubMedCrossRef
19.
Zurück zum Zitat Wu WC, Hsiao MW, Ye JC, Hung YC, Chang WC (2009) Malignant transformation of extragonadal endometriosis: a case report. Eur J Gynaecol Oncol 30:563–565PubMed Wu WC, Hsiao MW, Ye JC, Hung YC, Chang WC (2009) Malignant transformation of extragonadal endometriosis: a case report. Eur J Gynaecol Oncol 30:563–565PubMed
20.
Zurück zum Zitat Hiromura T, Tanaka YO, Nishioka T, Satoh M, Tomita K (2009) Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis. Br J Radiol 82:e20–e22PubMedCrossRef Hiromura T, Tanaka YO, Nishioka T, Satoh M, Tomita K (2009) Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis. Br J Radiol 82:e20–e22PubMedCrossRef
21.
Zurück zum Zitat Bertelsen L, Mellemkjaer L, Frederiksen K et al (2007) Risk for breast cancer among women with endometriosis. Int J Cancer 120:1372–1375PubMedCrossRef Bertelsen L, Mellemkjaer L, Frederiksen K et al (2007) Risk for breast cancer among women with endometriosis. Int J Cancer 120:1372–1375PubMedCrossRef
22.
Zurück zum Zitat Matalliotakis IM, Cakmak H, Mahutte N, Goumenou AG, Koumantakis G, Arici A (2008) The familial risk of breast cancer in women with endometriosis from Yale series. Surg Oncol 17:289–293PubMedCrossRef Matalliotakis IM, Cakmak H, Mahutte N, Goumenou AG, Koumantakis G, Arici A (2008) The familial risk of breast cancer in women with endometriosis from Yale series. Surg Oncol 17:289–293PubMedCrossRef
23.
Zurück zum Zitat Matsuo K, Alonsozana EL, Eno ML, Rosenshein NB, Im DD (2009) Primary peritoneal clear cell adenocarcinoma arising in previous abdominal scar for endometriosis surgery. Arch Gynecol Obstet 280:637–641PubMedCrossRef Matsuo K, Alonsozana EL, Eno ML, Rosenshein NB, Im DD (2009) Primary peritoneal clear cell adenocarcinoma arising in previous abdominal scar for endometriosis surgery. Arch Gynecol Obstet 280:637–641PubMedCrossRef
24.
Zurück zum Zitat Kobayashi S, Sasaki M, Goto T et al (2010) Endometrioid adenocarcinoma arising from endometriosis of the rectosigmoid. Dig Endosc 22:59–63PubMedCrossRef Kobayashi S, Sasaki M, Goto T et al (2010) Endometrioid adenocarcinoma arising from endometriosis of the rectosigmoid. Dig Endosc 22:59–63PubMedCrossRef
25.
Zurück zum Zitat Staats PN, Clement PB, Young RH (2007) Primary endometrioid adenocarcinoma of the vagina: a clinicopathologic study of 18 cases. Am J Surg Pathol 31:1490–1501PubMedCrossRef Staats PN, Clement PB, Young RH (2007) Primary endometrioid adenocarcinoma of the vagina: a clinicopathologic study of 18 cases. Am J Surg Pathol 31:1490–1501PubMedCrossRef
26.
Zurück zum Zitat Peiretti M, Zakashansky K, Melis GB, Mais V (2008) Unusual case of adenocarcinoma arising in endometriosis mimicking colorectal cancer in a young woman with a Müllerian anomaly. Fertil Steril 90:199.e13–5PubMedCrossRef Peiretti M, Zakashansky K, Melis GB, Mais V (2008) Unusual case of adenocarcinoma arising in endometriosis mimicking colorectal cancer in a young woman with a Müllerian anomaly. Fertil Steril 90:199.e13–5PubMedCrossRef
27.
Zurück zum Zitat Swiersz LM (2002) Role of endometriosis in cancer and tumor development. Ann NY Acad Sci 955:281–292PubMedCrossRef Swiersz LM (2002) Role of endometriosis in cancer and tumor development. Ann NY Acad Sci 955:281–292PubMedCrossRef
28.
Zurück zum Zitat Boruban MC, Jaishuen A, Sirisabya N et al (2008) Ovarian endometriosis associated with carcinoma and sarcoma: case report. Eur J Gynaecol Oncol 29:393–396PubMed Boruban MC, Jaishuen A, Sirisabya N et al (2008) Ovarian endometriosis associated with carcinoma and sarcoma: case report. Eur J Gynaecol Oncol 29:393–396PubMed
29.
Zurück zum Zitat Oppelt P, Renner SP, Strick R et al (2010) Correlation of high-risk human papilloma viruses but not of herpes viruses or Chlamydia trachomatis with endometriosis lesions. Fertil Steril 93:1778–1786PubMedCrossRef Oppelt P, Renner SP, Strick R et al (2010) Correlation of high-risk human papilloma viruses but not of herpes viruses or Chlamydia trachomatis with endometriosis lesions. Fertil Steril 93:1778–1786PubMedCrossRef
30.
Zurück zum Zitat Ali-Fehmi R, Khalifeh I, Bandyopadhyay S et al (2006) Patterns of loss of heterozygosity at 10q23.3 and microsatellite instability in endometriosis, atypical endometriosis, and ovarian carcinoma arising in association with endometriosis. Int J Gynecol Pathol 25:223–229PubMedCrossRef Ali-Fehmi R, Khalifeh I, Bandyopadhyay S et al (2006) Patterns of loss of heterozygosity at 10q23.3 and microsatellite instability in endometriosis, atypical endometriosis, and ovarian carcinoma arising in association with endometriosis. Int J Gynecol Pathol 25:223–229PubMedCrossRef
31.
Zurück zum Zitat Borghese B, Mondon F, Noël JC et al (2008) Gene expression profile for ectopic versus eutopic endometrium provides new insights into endometriosis oncogenic potential. Mol Endocrinol 22:2557–2562PubMedCrossRef Borghese B, Mondon F, Noël JC et al (2008) Gene expression profile for ectopic versus eutopic endometrium provides new insights into endometriosis oncogenic potential. Mol Endocrinol 22:2557–2562PubMedCrossRef
32.
Zurück zum Zitat Mandai M, Yamaguchi K, Matsumura N, Baba T, Konishi I (2009) Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management. Int J Clin Oncol 14:383–391PubMedCrossRef Mandai M, Yamaguchi K, Matsumura N, Baba T, Konishi I (2009) Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management. Int J Clin Oncol 14:383–391PubMedCrossRef
33.
Zurück zum Zitat Götte M, Wolf M, Staebler A et al (2008) Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma. J Pathol 215:317–329PubMedCrossRef Götte M, Wolf M, Staebler A et al (2008) Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma. J Pathol 215:317–329PubMedCrossRef
35.
Zurück zum Zitat Kondi-Paphitis A, Smyrniotis B, Liapis A, Kontoyanni A, Deligeorgi H (1998) Stromal sarcoma arising on endometriosis. A clinicopathological and immunohistochemical study of 4 cases. Eur J Gynaecol Oncol 19:588–590PubMed Kondi-Paphitis A, Smyrniotis B, Liapis A, Kontoyanni A, Deligeorgi H (1998) Stromal sarcoma arising on endometriosis. A clinicopathological and immunohistochemical study of 4 cases. Eur J Gynaecol Oncol 19:588–590PubMed
36.
Zurück zum Zitat Kobayashi H, Yamada Y, Kanayama S et al (2009) The role of iron in the pathogenesis of endometriosis. Gynecol Endocrinol 25:39–52PubMedCrossRef Kobayashi H, Yamada Y, Kanayama S et al (2009) The role of iron in the pathogenesis of endometriosis. Gynecol Endocrinol 25:39–52PubMedCrossRef
37.
Zurück zum Zitat Yap OW, Bhat G, Liu L, Tollefsbol TO (2009) Epigenetic modifications of the estrogen receptor β gene in epithelial ovarian cancer cells. Anticancer Res 29:139–144PubMed Yap OW, Bhat G, Liu L, Tollefsbol TO (2009) Epigenetic modifications of the estrogen receptor β gene in epithelial ovarian cancer cells. Anticancer Res 29:139–144PubMed
38.
Zurück zum Zitat Karita M, Yamashita Y, Hayashi A, et al. (2011) Does advanced-stage endometriosis affect the gene expression of estrogen and progesterone receptors in granulosa cells? Fertil Steril 95:889–894PubMedCrossRef Karita M, Yamashita Y, Hayashi A, et al. (2011) Does advanced-stage endometriosis affect the gene expression of estrogen and progesterone receptors in granulosa cells? Fertil Steril 95:889–894PubMedCrossRef
39.
Zurück zum Zitat Bulun SE, Cheng YH, Yin P et al (2006) Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol 248:94–103PubMedCrossRef Bulun SE, Cheng YH, Yin P et al (2006) Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol 248:94–103PubMedCrossRef
40.
Zurück zum Zitat Govindan S, Ahmad SN, Vedicherla B et al (2007) Association of progesterone receptor gene polymorphism (PROGINS) with endometriosis, uterine fibroids and breast cancer. Cancer Biomark 3:73–78PubMed Govindan S, Ahmad SN, Vedicherla B et al (2007) Association of progesterone receptor gene polymorphism (PROGINS) with endometriosis, uterine fibroids and breast cancer. Cancer Biomark 3:73–78PubMed
41.
Zurück zum Zitat Grammatikakis I, Zervoudis S, Evangelinakis N, Tziortzioti V (2010) Endometrium and ovarian cancer synchronous to endometriosis—a retrospective study of our experience of 7 years. J Med Life 3:76–79PubMed Grammatikakis I, Zervoudis S, Evangelinakis N, Tziortzioti V (2010) Endometrium and ovarian cancer synchronous to endometriosis—a retrospective study of our experience of 7 years. J Med Life 3:76–79PubMed
42.
Zurück zum Zitat Kondi-Pafiti A, Grapsa D, Liapis A, Papadias K, Kairi-Vassilatou E, Hasiakos D (2008) Synchronous ovarian and endometrial carcinoma: a strong link to endometriosis? Eur J Gynaecol Oncol 29:256–259PubMed Kondi-Pafiti A, Grapsa D, Liapis A, Papadias K, Kairi-Vassilatou E, Hasiakos D (2008) Synchronous ovarian and endometrial carcinoma: a strong link to endometriosis? Eur J Gynaecol Oncol 29:256–259PubMed
43.
Zurück zum Zitat Vaissière T, Sawan C, Herceg Z (2008) Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutat Res 659:40–48PubMedCrossRef Vaissière T, Sawan C, Herceg Z (2008) Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutat Res 659:40–48PubMedCrossRef
44.
Zurück zum Zitat Takemura Y, Osuga Y, Harada M et al (2005) Serum adiponectin concentrations are decreased in women with endometriosis. Hum Reprod 20:3510–3513PubMedCrossRef Takemura Y, Osuga Y, Harada M et al (2005) Serum adiponectin concentrations are decreased in women with endometriosis. Hum Reprod 20:3510–3513PubMedCrossRef
45.
Zurück zum Zitat Beebe-Dimmer JL, Zuhlke KA, Ray AM, Lange EM, Cooney KA (2010) Genetic variation in adiponectin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans. Prostate Cancer Prostatic Dis 13:362–368PubMedCrossRef Beebe-Dimmer JL, Zuhlke KA, Ray AM, Lange EM, Cooney KA (2010) Genetic variation in adiponectin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans. Prostate Cancer Prostatic Dis 13:362–368PubMedCrossRef
46.
Zurück zum Zitat Massuger L, Roelofsen T, Ham M, Bulten J (2010) The origin of serous ovarian cancer may be found in the uterus: a novel hypothesis. Med Hypotheses 74:859–861PubMedCrossRef Massuger L, Roelofsen T, Ham M, Bulten J (2010) The origin of serous ovarian cancer may be found in the uterus: a novel hypothesis. Med Hypotheses 74:859–861PubMedCrossRef
47.
Zurück zum Zitat Depalo R, Cavallini A, Lorusso F et al (2009) Apoptosis in normal ovaries of women with and without endometriosis. Reprod Biomed Online 19:808–815PubMedCrossRef Depalo R, Cavallini A, Lorusso F et al (2009) Apoptosis in normal ovaries of women with and without endometriosis. Reprod Biomed Online 19:808–815PubMedCrossRef
48.
Zurück zum Zitat Hirabayashi K, Yasuda M, Kajiwara H et al (2009) Clear cell adenocarcinoma arising from adenomyosis. Int J Gynecol Pathol 28:262–266PubMedCrossRef Hirabayashi K, Yasuda M, Kajiwara H et al (2009) Clear cell adenocarcinoma arising from adenomyosis. Int J Gynecol Pathol 28:262–266PubMedCrossRef
49.
Zurück zum Zitat Mhawech P, Kinkel K, Vlastos G, Pelte MF (2002) Ovarian carcinomas in endometriosis: an immunohistochemical and comparative genomic hybridization study. Int J Gynecol Pathol 21:401–406PubMedCrossRef Mhawech P, Kinkel K, Vlastos G, Pelte MF (2002) Ovarian carcinomas in endometriosis: an immunohistochemical and comparative genomic hybridization study. Int J Gynecol Pathol 21:401–406PubMedCrossRef
50.
Zurück zum Zitat Barros SP, Offenbacher S (2009) Epigenetics: connecting environment and genotype to phenotype and disease. J Dent Res 88:400–408PubMedCrossRef Barros SP, Offenbacher S (2009) Epigenetics: connecting environment and genotype to phenotype and disease. J Dent Res 88:400–408PubMedCrossRef
51.
Zurück zum Zitat Van Patten K, Parkash V, Jain D (2010) Cadherin expression in gastrointestinal tract endometriosis: possible role in deep tissue invasion and development of malignancy. Mod Pathol 23:38–44PubMedCrossRef Van Patten K, Parkash V, Jain D (2010) Cadherin expression in gastrointestinal tract endometriosis: possible role in deep tissue invasion and development of malignancy. Mod Pathol 23:38–44PubMedCrossRef
52.
Zurück zum Zitat Shaco-Levy R, Sharabi S, Benharroch D, Piura B, Sion-Vardy N (2008) Matrix metalloproteinases 2 and 9, E-cadherin, and beta-catenin expression in endometriosis, low-grade endometrial carcinoma and non-neoplastic eutopic endometrium. Eur J Obstet Gynecol Reprod Biol 139:226–232PubMedCrossRef Shaco-Levy R, Sharabi S, Benharroch D, Piura B, Sion-Vardy N (2008) Matrix metalloproteinases 2 and 9, E-cadherin, and beta-catenin expression in endometriosis, low-grade endometrial carcinoma and non-neoplastic eutopic endometrium. Eur J Obstet Gynecol Reprod Biol 139:226–232PubMedCrossRef
53.
Zurück zum Zitat Nyiraneza C, Marbaix E, Smets M, Galant C, Sempoux C, Dahan K (2010) High risk for neoplastic transformation of endometriosis in a carrier of Lynch syndrome. Fam Cancer 9:383–387PubMedCrossRef Nyiraneza C, Marbaix E, Smets M, Galant C, Sempoux C, Dahan K (2010) High risk for neoplastic transformation of endometriosis in a carrier of Lynch syndrome. Fam Cancer 9:383–387PubMedCrossRef
54.
Zurück zum Zitat Kobayashi H, Kajiwara H, Kanayama S et al (2009) Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review). Oncol Rep 22:233–240PubMedCrossRef Kobayashi H, Kajiwara H, Kanayama S et al (2009) Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review). Oncol Rep 22:233–240PubMedCrossRef
56.
Zurück zum Zitat Keita M, Bessette P, Pelmus M, Ainmelk Y, Aris A (2010) Expression of interleukin-1 (IL-1) ligands system in the most common endometriosis-associated ovarian cancer subtypes. J Ovarian Res 3:3PubMedCrossRef Keita M, Bessette P, Pelmus M, Ainmelk Y, Aris A (2010) Expression of interleukin-1 (IL-1) ligands system in the most common endometriosis-associated ovarian cancer subtypes. J Ovarian Res 3:3PubMedCrossRef
57.
Zurück zum Zitat Wilson AG (2008) Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases. J Periodontol 79:1514–1519PubMedCrossRef Wilson AG (2008) Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases. J Periodontol 79:1514–1519PubMedCrossRef
58.
Zurück zum Zitat Mach P, Blecharz P, Basta P et al (2010) Differences in the soluble HLA-G blood serum concentration levels in patients with ovarian cancer and ovarian and deep endometriosis. Am J Reprod Immunol 63:387–395PubMedCrossRef Mach P, Blecharz P, Basta P et al (2010) Differences in the soluble HLA-G blood serum concentration levels in patients with ovarian cancer and ovarian and deep endometriosis. Am J Reprod Immunol 63:387–395PubMedCrossRef
59.
Zurück zum Zitat Gemmill JA, Stratton P, Cleary SD, Ballweg ML, Sinaii N (2010) Cancers, infections, and endocrine diseases in women with endometriosis. Fertil Steril 94:1627–1631PubMedCrossRef Gemmill JA, Stratton P, Cleary SD, Ballweg ML, Sinaii N (2010) Cancers, infections, and endocrine diseases in women with endometriosis. Fertil Steril 94:1627–1631PubMedCrossRef
60.
Zurück zum Zitat Khan KN, Kitajima M, Hiraki K et al (2008) Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor, macrophages and ovarian steroids. Am J Reprod Immunol 60:383–404PubMedCrossRef Khan KN, Kitajima M, Hiraki K et al (2008) Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor, macrophages and ovarian steroids. Am J Reprod Immunol 60:383–404PubMedCrossRef
Metadaten
Titel
Relationship between endometriosis and cancer from current perspective
verfasst von
Arif Kokcu
Publikationsdatum
01.12.2011
Verlag
Springer-Verlag
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 6/2011
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-011-2047-y

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