nach oben

Archives of Gynecology and Obstetrics

Erschienen in:

01.04.2014 | Position Statements and Guidelines

Tocolysis for preterm labor: Expert opinion

verfasst von: Irène Hösli, Christiane Sperschneider, Gero Drack, Roland Zimmermann, Daniel Surbek, Olivier Irion

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2014

Einloggen, um Zugang zu erhalten

Abstract

Tocolysis is an important treatment in the improvement of outcome in preterm labor and preterm birth, provided that its use follows clear evidence-based recommendations. In this expert opinion, the most recent evidence about efficacy and side effects of different tocolytics is being reviewed and evidence-based recommendation about diagnosis and treatment of preterm labor is given. Further aspects such as progesterone administration or antibiotic treatment for the prevention of preterm birth are included. Our review demonstrates that an individualized choice of different tocolytics and additional treatments is necessary to improve short- and long-term neonatal outcome in preterm labor and preterm birth.

Bundesamt für Statistik aktuell (2010) Gesundheit der Neugeborenen 2008 Frühgeburten, Mehrlingsschwangerschaften und Wachstumsretardierung. wwwadminch

McCormick MC (1985) The contribution of low birth weight to infant mortality and childhood morbidity. N Engl J Med 312(2):82–90. doi:10.1056/NEJM198501103120204 PubMedCrossRef

Ness A, Visintine J, Ricci E, Berghella V (2007) Does knowledge of cervical length and fetal fibronectin affect management of women with threatened preterm labor? A randomized trial. Am J Obstet Gynecol 197(4):426 e1–426 e7. doi:S0002-9378(07)00884-8 CrossRef

Surbek D, D G, Irion O, Nelle M, Hösli I (2009) Lungenreifungsinduktion bei drohender Frühgeburt: Standardindikationen und Dosierung. SGGG Expertenbrief No 34

Goffinet F (2005) Primary predictors of preterm labour. BJOG 112(Suppl 1):38–47. doi:10.1111/j.1471-0528.2005.00583.x PubMedCrossRef

Moreau C, Kaminski M, Ancel PY, Bouyer J, Escande B, Thiriez G et al (2005) Previous induced abortions and the risk of very preterm delivery: results of the EPIPAGE study. BJOG 112(4):430–437. doi:10.1111/j.1471-0528.2004.00478.x PubMedCrossRef

Gomez R, Galasso M, Romero R, Mazor M, Sorokin Y, Goncalves L et al (1994) Ultrasonographic examination of the uterine cervix is better than cervical digital examination as a predictor of the likelihood of premature delivery in patients with preterm labor and intact membranes. Am J Obstet Gynecol 171(4):956–964. doi:0002-9378(94)90014-0 PubMedCrossRef

Crane JM, Van den Hof M, Armson BA, Liston R (1997) Transvaginal ultrasound in the prediction of preterm delivery: singleton and twin gestations. Obstet Gynecol 90(3):357–363. doi:S0029-7844(97)00277-9 PubMedCrossRef

Sonek JD, Iams JD, Blumenfeld M, Johnson F, Landon M, Gabbe S (1990) Measurement of cervical length in pregnancy: comparison between vaginal ultrasonography and digital examination. Obstet Gynecol 76(2):172–175PubMed

10.

Schutte MF, Treffers PE, Kloosterman GJ, Soepatmi S (1983) Management of premature rupture of membranes: the risk of vaginal examination to the infant. Am J Obstet Gynecol 146(4):395–400PubMed

11.

Munson LA, Graham A, Koos BJ, Valenzuela GJ (1985) Is there a need for digital examination in patients with spontaneous rupture of the membranes? Am J Obstet Gynecol 153(5):562–563. doi:0002-9378(85)90474-0 PubMedCrossRef

12.

Birkenmaier A, Ries JJ, Kuhle J, Burki N, Lapaire O, Hosli I (2012) Placental alpha-microglobulin-1 to detect uncertain rupture of membranes in a European cohort of pregnancies. Arch Gynecol Obstet. doi:10.1007/s00404-011-1895-9 PubMed

13.

Hassan SS, Romero R, Berry SM, Dang K, Blackwell SC, Treadwell MC et al (2000) Patients with an ultrasonographic cervical length < or = 15 mm have nearly a 50% risk of early spontaneous preterm delivery. Am J Obstet Gynecol 182(6):1458–1467. doi:S0002-9378(00)81396-4 PubMedCrossRef

14.

ACOG Practice Bulletin (2001) Assessment of risk factors for preterm birth. Clinical management guidelines for obstetrician–gynecologists. Number 31, October 2001. (Replaces Technical Bulletin number 206, June 1995; Committee Opinion number 172, May 1996; Committee Opinion number 187, September 1997; Committee Opinion number 198, February 1998; and Committee Opinion number 251, January 2001). Obstet Gynecol 98(4):709–716

15.

Kagan KO, To M, Tsoi E, Nicolaides KH (2006) Preterm birth: the value of sonographic measurement of cervical length. BJOG 113(Suppl 3):52–56. doi:10.1111/j.1471-0528.2006.01124.x PubMedCrossRef

16.

Chandiramani M, Di Renzo GC, Gottschalk E, Helmer H, Henrich W, Hoesli I et al (2011) Fetal fibronectin as a predictor of spontaneous preterm birth: a European perspective. J Matern Fetal Neonatal Med 24(2):330–336. doi:10.3109/14767058.2010.496879 PubMedCrossRef

17.

Crowley P (2000) Prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev (2):CD000065. 10.1002/14651858.CD000065

18.

American College of O, Gynecologists, Committee on Practice B-O (2012) ACOG practice bulletin no. 127: management of preterm labor. Obstet Gynecol 119(6):1308–1317. doi:10.1097/AOG.0b013e31825af2f0 CrossRef

19.

Gyetvai K, Hannah ME, Hodnett ED, Ohlsson A (1999) Tocolytics for preterm labor: a systematic review. Obstet Gynecol 94(5 Pt 2):869–877PubMedCrossRef

20.

RCOG (2011) Tocolysis for women in preterm labour guidelines for the management of spontaneous preterm labour Green top clinical guideline No 1(B)

21.

Conde-Agudelo A, Romero R, Kusanovic JP (2011) Nifedipine in the management of preterm labor: a systematic review and metaanalysis. Am J Obstet Gynecol 204(2):134 e1–134 e20. doi:10.1016/j.ajog.2010.11.038 CrossRef

22.

DGGG (2010) Leitlinien Medikamentöse Wehenhemmung bei drohender Frühgeburt

23.

de Heus R, Mol BW, Erwich JJ, van Geijn HP, Gyselaers WJ, Hanssens M et al (2009) Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study. BMJ 338:b744PubMedCentralPubMedCrossRef

24.

Herzog S, Cunze T, Martin M, Osmers R, Gleiter C, Kuhn W (1999) Pulsatile vs. continuous parenteral tocolysis: comparison of side effects. Eur J Obstet Gynecol Reprod Biol 85(2):199–204. doi:S0301211599000305 PubMedCrossRef

25.

Anotayanonth S, Subhedar NV, Garner P, Neilson JP, Harigopal S (2004) Betamimetics for inhibiting preterm labour. Cochrane Database Syst Rev. (4):CD004352. doi: 10.1002/14651858.CD004352.pub2

26.

The Worldwide Atosiban versus Beta-agonists Study Group (2001) Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. BJOG 108(2):133–142CrossRef

27.

Coomarasamy A, Knox EM, Gee H, Khan KS (2002) Oxytocin antagonists for tocolysis in preterm labour–a systematic review. Med Sci Monit 8(11):RA268–RA273PubMed

28.

Romero R, Sibai BM, Sanchez-Ramos L, Valenzuela GJ, Veille JC, Tabor B et al (2000) An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am J Obstet Gynecol 182(5):1173–1183PubMedCrossRef

29.

Di Renzo GC, Roura LC (2006) Guidelines for the management of spontaneous preterm labor. J Perinat Med 34(5):359–366. doi:10.1515/JPM.2006.073 PubMedCrossRef

30.

Tsatsaris V, Papatsonis D, Goffinet F, Dekker G, Carbonne B (2001) Tocolysis with nifedipine or beta-adrenergic agonists: a meta-analysis. Obstet Gynecol 97(5 Pt 2):840–847. doi:S0029784400012126 PubMedCrossRef

31.

King JF, Flenady VJ, Papatsonis DN, Dekker GA, Carbonne B (2003) Calcium channel blockers for inhibiting preterm labour. Cochrane Database Syst Rev. (1):CD002255. doi: 10.1002/14651858.CD002255

32.

Haas DM, Caldwell DM, Kirkpatrick P, McIntosh JJ, Welton NJ (2012) Tocolytic therapy for preterm delivery: systematic review and network meta-analysis. BMJ 345:e6226PubMedCrossRef

33.

Papatsonis DN, Van Geijn HP, Ader HJ, Lange FM, Bleker OP, Dekker GA (1997) Nifedipine and ritodrine in the management of preterm labor: a randomized multicenter trial. Obstet Gynecol 90(2):230–234. doi:10.1016/S0029-7844(97)00182-8 PubMedCrossRef

34.

Zimmermann R (2012) Handbuch Geburtshilfe

35.

Silberschmidt AL, Kuhn-Velten WN, Juon AM, Zimmermann R, von Mandach U (2008) Nifedipine concentration in maternal and umbilical cord blood after nifedipine gastrointestinal therapeutic system for tocolysis. BJOG 115(4):480–485. doi:10.1111/j.1471-0528.2007.01630.x PubMedCrossRef

36.

Juon AM, Kuhn-Velten WN, Burkhardt T, Krahenmann F, Zimmermann R, von Mandach U (2008) Nifedipine gastrointestinal therapeutic system (GITS) as an alternative to slow-release for tocolysis–tolerance and pharmacokinetic profile. Eur J Obstet Gynecol Reprod Biol 140(1):27–32. doi:10.1016/j.ejogrb.2008.02.003 PubMedCrossRef

37.

Magee LA, Miremadi S, Li J, Cheng C, Ensom MH, Carleton B et al (2005) Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia. Am J Obstet Gynecol 193(1):153–163. doi:10.1016/j.ajog.2004.11.059 PubMedCrossRef

38.

sapp.info (2010) Monographie Nifedipin. www sappinfo Monographie Nifedipin

39.

Haas DM, Imperiale TF, Kirkpatrick PR, Klein RW, Zollinger TW, Golichowski AM (2009) Tocolytic therapy: a meta-analysis and decision analysis. Obstet Gynecol 113(3):585–594. doi:10.1097/AOG.0b013e318199924a PubMedCrossRef

40.

King J, Flenady V, Cole S, Thornton S (2005) Cyclo-oxygenase (COX) inhibitors for treating preterm labour. Cochrane Database Syst Rev (2):CD001992. doi:10.1002/14651858.CD001992.pub2

41.

Smith GN, Walker MC, Ohlsson A, O’Brien K, Windrim R (2007) Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor. Am J Obstet Gynecol 196(1):37 e1–37.e8. doi:10.1016/j.ajog.2006.10.868 CrossRef

42.

Crowther CA, Hiller JE, Doyle LW (2002) Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev (4):CD001060. doi: 10.1002/14651858.CD001060

43.

Grimes DA, Nanda K (2006) Magnesium sulfate tocolysis: time to quit. Obstet Gynecol 108(4):986–989. doi:10.1097/01.AOG.0000236445.18265.93 PubMedCrossRef

44.

Jeyabalan A, Caritis SN (2002) Pharmacologic inhibition of preterm labor. Clin Obstet Gynecol 45(1):99–113PubMedCrossRef

45.

Rouse DJ, Hirtz DG, Thom E, Varner MW, Spong CY, Mercer BM et al (2008) A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy. N Engl J Med 359(9):895–905. doi:10.1056/NEJMoa0801187 PubMedCentralPubMedCrossRef

46.

SGGG (2007) Expertenbrief No. 23 “Off Label Use” von Arzneimitteln in der Gynäkologie und Geburtshilfe

47.

Lyell DJ, Pullen KM, Mannan J, Chitkara U, Druzin ML, Caughey AB et al (2008) Maintenance nifedipine tocolysis compared with placebo: a randomized controlled trial. Obstet Gynecol 112(6):1221–1226. doi:10.1097/AOG.0b013e31818d8386 PubMedCrossRef

48.

Dodd JM, Crowther CA, Dare MR, Middleton P (2006) Oral betamimetics for maintenance therapy after threatened preterm labour. Cochrane Database Syst Rev (1):CD003927. doi: 10.1002/14651858.CD003927.pub2

49.

Whitworth M, Quenby S (2008) Prophylactic oral betamimetics for preventing preterm labour in singleton pregnancies. Cochrane Database Syst Rev (1):CD006395. doi: 10.1002/14651858.CD006395.pub2

50.

Papatsonis D, Flenady V, Liley H (2009) Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour. Cochrane Database Syst Rev (1):CD005938. doi: 10.1002/14651858.CD005938.pub2

51.

Sosa C, Althabe F, Belizan J, Bergel E (2004) Bed rest in singleton pregnancies for preventing preterm birth. Cochrane Database Syst Rev (1):CD003581. doi: 10.1002/14651858.CD003581.pub2

52.

Heaman M, Gupton A (1998) Perceptions of bed rest by women with high-risk pregnancies: a comparison between home and hospital. Birth 25(4):252–258PubMedCrossRef

53.

Heaman MI, Blanchard JF, Gupton AL, Moffatt ME, Currie RF (2005) Risk factors for spontaneous preterm birth among Aboriginal and non-Aboriginal women in Manitoba. Paediatr Perinat Epidemiol 19(3):181–193. doi:10.1111/j.1365-3016.2005.00644.x PubMedCrossRef

54.

Wachter R, Brenneisen R, Hamburger M, Mennet M, Schnelle M, Worel AM et al (2011) Leaf press juice from Bryophyllum pinnatum (Lamarck) Oken induces myometrial relaxation. Phytomedicine. doi:10.1016/j.phymed.2011.06.032 PubMed

55.

Plangger N, Rist L, Zimmermann R, von Mandach U (2006) Intravenous tocolysis with Bryophyllum pinnatum is better tolerated than beta-agonist application. Eur J Obstet Gynecol Reprod Biol 124(2):168–172. doi:10.1016/j.ejogrb.2005.05.013 PubMedCrossRef

56.

Gwehenberger B, Rist L, Huch R, von Mandach U (2004) Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility. Eur J Obstet Gynecol Reprod Biol 113(2):164–171. doi:10.1016/S0301-2115(03)00370-1 PubMedCrossRef

57.

King J, Flenady V (2002) Prophylactic antibiotics for inhibiting preterm labour with intact membranes. Cochrane Database Syst Rev (4):CD000246. doi: 10.1002/14651858.CD000246

58.

Kenyon S, Pike K, Jones DR, Brocklehurst P, Marlow N, Salt A et al (2008) Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 372(9646):1319–1327. doi:10.1016/S0140-6736(08) PubMedCrossRef

59.

Verani JR, McGee L, Schrag SJ (2010) Prevention of perinatal group B streptococcal disease—revised guidelines from CDC. MMWR Recomm Rep 59(RR-10):1–36PubMed

60.

Kenyon SL, Taylor DJ, Tarnow-Mordi W, ORACLE Collaborative Group (2001) Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. Lancet 357(9261):979–988. doi:S0140673600042331 PubMedCrossRef

61.

Dodd JM, Flenady V, Cincotta R, Crowther CA (2006) Prenatal administration of progesterone for preventing preterm birth. Cochrane Database Syst Rev (1):CD004947. doi: 10.1002/14651858.CD004947.pub2

62.

Hassan SS, Romero R, Vidyadhari D, Fusey S, Baxter JK, Khandelwal M et al (2011) Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 38(1):18–31. doi:10.1002/uog.9017 PubMedCentralPubMedCrossRef

63.

Romero R, Nicolaides K, Conde-Agudelo A, Tabor A, O’Brien JM, Cetingoz E et al (2012) Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. Am J Obstet Gynecol 206(2):124 e1–124 e19. doi:10.1016/j.ajog.2011.12.003 CrossRef

64.

Meis PJ, Aleman A (2004) Progesterone treatment to prevent preterm birth. Drugs 64(21):2463–2474PubMedCrossRef

65.

Sanchez-Ramos L, Kaunitz AM, Delke I (2005) Progestational agents to prevent preterm birth: a meta-analysis of randomized controlled trials. Obstet Gynecol 105(2):273–279. doi:10.1097/01.AOG.0000150559.59531.b2 PubMedCrossRef

66.

Likis FE, Edwards DR, Andrews JC, Woodworth AL, Jerome RN, Fonnesbeck CJ et al (2012) Progestogens for preterm birth prevention: a systematic review and meta-analysis. Obstet Gynecol 120(4):897–907. doi:10.1097/AOG.0b013e3182699a15 PubMedCrossRef

Titel: Tocolysis for preterm labor: Expert opinion
verfasst von: Irène Hösli
Christiane Sperschneider
Gero Drack
Roland Zimmermann
Daniel Surbek
Olivier Irion
Publikationsdatum: 01.04.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2014
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-013-3137-9

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Ambulantisierung: Erste Erfahrungen mit dem Hybrid-DRG

02.05.2024 DCK 2024 Kongressbericht

Die Hybrid-DRG-Verordnung soll dazu führen, dass mehr chirurgische Eingriffe ambulant durchgeführt werden, wie es in anderen Ländern schon länger üblich ist. Die gleiche Vergütung im ambulanten und stationären Sektor hatten Niedergelassene schon lange gefordert. Aber die Umsetzung bereitet ihnen doch Kopfzerbrechen.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Harninkontinenz: Netz-Op. erfordert über lange Zeit intensive Nachsorge

30.04.2024 Harninkontinenz Nachrichten

Frauen mit Belastungsinkontinenz oder Organprolaps sind nach einer Netz-Operation keineswegs beschwerdefrei. Vielmehr scheint die Krankheitslast weiterhin hoch zu sein, sogar höher als von harninkontinenten Frauen, die sich nicht haben operieren lassen.

Welche Übungen helfen gegen Diastase recti abdominis?

30.04.2024 Schwangerenvorsorge Nachrichten

Die Autorinnen und Autoren einer aktuellen Studie aus Griechenland sind sich einig, dass Bewegungstherapie, einschließlich Übungen zur Stärkung der Bauchmuskulatur und zur Stabilisierung des Rumpfes, eine Diastase recti abdominis postpartum wirksam reduzieren kann. Doch vieles ist noch nicht eindeutig belegt.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2014

Chlamydia trachomatis infection: implications for HPV status and cervical cancer

Determinants of alcohol cessation, reduction and no reduction during pregnancy

The role of a personalized dietary intervention in managing gestational weight gain: a prospective, controlled study in a low-risk antenatal population

Effect of lesion location on endometriotic adhesion and angiogenesis in SCID mice