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Erschienen in: Archives of Gynecology and Obstetrics 5/2017

10.03.2017 | Maternal-Fetal Medicine

Genetic polymorphism of MTHFR C677T with preterm birth and low birth weight susceptibility: a meta-analysis

verfasst von: Han Wu, Ping Zhu, Xingyi Geng, Zhong Liu, Liangliang Cui, Zhongchun Gao, Baofa Jiang, Liping Yang

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2017

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Abstract

Purpose

This study aimed at clarifying the association of maternal and neonatal methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms with preterm birth (PTB) and low birth weight (LBW) susceptibility, respectively.

Materials and methods

A systematic search of Embase, Medline, China Biological Medicine Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wanfang Database was performed before June, 2016. The frequencies of maternal and neonatal MTHFR C677T genotypes in the cases and controls and other information were extracted by two independent investigators. Odds ratios (ORs) with 95% confidence intervals (CIs) were adopted to estimate the relationships between MTHFR C677T polymorphisms and PTB as well as LBW by random or fixed effect models.

Results

Twenty-five studies from 20 articles concerning maternal and neonatal MTHFR C677T gene polymorphism with PTB and LBW were included in this study. Maternal MTHFR C677T polymorphism was associated with PTB risk under allele contrast (T vs. C, OR = 1.36, 95% CI 1.02–1.81), homozygote (TT vs. CC, OR = 1.70, 95% CI 1.07–2.68), and recessive (TT vs. CT + CC, OR = 1.49, 95% CI 1.00–2.22) model, but not dominant or heterozygote model. Maternal MTHFR C677T polymorphism was also associated with LBW risk under allele contrast (OR = 1.69, 95% CI 1.25–2.28), homozygote (OR = 2.26, 95% CI 1.44–3.54), dominant (OR = 1.71, 95% CI 1.19–2.47), recessive (OR = 1.79, 95% CI 1.42–2.26) model, but not heterozygote model. No associations between neonatal MTHFR C677T polymorphism and PTB or LBW were found under all genetic models.

Conclusions

Identification of maternal MTHFR C677T mutation may play a key role for primary prevention of PTB as well as LBW and screening pregnant women of high risk in developing countries.
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Metadaten
Titel
Genetic polymorphism of MTHFR C677T with preterm birth and low birth weight susceptibility: a meta-analysis
verfasst von
Han Wu
Ping Zhu
Xingyi Geng
Zhong Liu
Liangliang Cui
Zhongchun Gao
Baofa Jiang
Liping Yang
Publikationsdatum
10.03.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 5/2017
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-017-4322-z

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