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08.04.2017 | Review

Etiology, pathophysiology and biomarkers of interstitial cystitis/painful bladder syndrome

verfasst von: Sourav Sanchit Patnaik, Antonio Simone Laganà, Salvatore Giovanni Vitale, Salvatore Butticè, Marco Noventa, Salvatore Gizzo, Gaetano Valenti, Agnese Maria Chiara Rapisarda, Valentina Lucia La Rosa, Carlo Magno, Onofrio Triolo, Vani Dandolu

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 6/2017

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Abstract

Purpose

Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic pain syndrome and a chronic inflammatory condition prevalent in women that leads to urgency, sleep disruption, nocturia and pain in the pelvic area, to the detriment of the sufferer’s quality of life. The aim of this review is to highlight the newest diagnostic strategies and potential therapeutic techniques.

Methods

A comprehensive literature review was performed on MEDLINE, PubMed, and Cochrane databases gathering all literature about “Interstitial cystitis” and “Painful Bladder Syndrome”. Visual analogue scales, epidemiological strategies, pain questionnaires and similar techniques were not included in this literature survey.

Results

The etiology, exact diagnosis and epidemiology of IC/PBS are still not clearly understood. To date, its prevalence is estimated to be in the range of 45 per 100,000 women and 8 per 100,000 men, whereas joint prevalence in both sexes is 10.6 cases per 100,000. There are no “gold standards” in the diagnosis or detection of IC/PBS, therefore, several etiological theories were investigated, such as permeability, glycosaminoglycans, mast cell, infection and neuroendocrine theory to find new diagnostic strategies and potential biomarkers.

Conclusion

Due to the fact that this disease is of an intricate nature, and that many of its symptoms overlap with other concomitant diseases, it could be suggested to classify the patients with emphasis on the phenotype, as well as their symptom clusters, to tailor the diagnostic and management choices according to the observed biomarkers.

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Titel: Etiology, pathophysiology and biomarkers of interstitial cystitis/painful bladder syndrome
verfasst von: Sourav Sanchit Patnaik
Antonio Simone Laganà
Salvatore Giovanni Vitale
Salvatore Butticè
Marco Noventa
Salvatore Gizzo
Gaetano Valenti
Agnese Maria Chiara Rapisarda
Valentina Lucia La Rosa
Carlo Magno
Onofrio Triolo
Vani Dandolu
Publikationsdatum: 08.04.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 6/2017
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4364-2

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