Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Das Thema chronische Unterbauch- und Viszeralschmerzen wird im Live-Webinar am 7. Mai von 17.30 bis 19 Uhr aus internistischer, gynäkologischer und psychologisch-neurowissenschaftlicher Perspektive beleuchtet. Besprochen werden krankheitsbedingte Ursachen, Mechanismen der kognitiven Schmerzmodulation sowie mögliche Therapieoptionen. Die Fortbildung ist mit 2 CME-Punkten zertifiziert. Melden Sie sich jetzt an!
Erweiterte Suche
Anmelden
nach oben
Journal of Neurology
Erschienen in: Journal of Neurology 2/2011

01.05.2011

Treatment of dysautonomia in extrapyramidal disorders

verfasst von: Tjalf Ziemssen, Gerd Fuchs, Wolfgang Greulich, Heinz Reichmann, Michael Schwarz, Birgit Herting

Erschienen in: Journal of Neurology | Sonderheft 2/2011

Einloggen, um Zugang zu erhalten

Abstract

Although extrapyramidal diseases are commonly thought to solely affect the (extrapyramidal) motor system, non-motor symptoms such as behavioural abnormalities, dysautonomia, sleep disturbances and sensory dysfunctions are also frequently observed. Autonomic dysfunction is an important clinical component of extrapyramidal disease, but it is often not formally assessed, and thus frequently misdiagnosed. Symptoms of autonomic dysfunction can impact more on quality of life than motor symptoms. Appropriate symptom-oriented diagnosis and symptomatic treatment as part of an interdisciplinary approach can greatly benefit the patient. This review elaborates a limited overview on the treatment of cardiovascular, gastrointestinal, urogenital and sudomotor autonomic dysfunction in various extrapyramidal syndromes.
Literatur
1.
Albanese A, Brisinda G, Bentivoglio AR, Maria G (2003) Treatment of outlet obstruction constipation in Parkinson’s disease with botulinum neurotoxin A. Am J Gastroenterol 98:1439–1440PubMedCrossRef
2.
Ashraf W, Wszolek ZK, Pfeiffer RF, Normand M, Maurer K, Srb F, Edwards LL, Quigley EM (1995) Anorectal function in fluctuating (on-off) Parkinson’s disease: evaluation by combined anorectal manometry and electromyography. Mov Disord 10:650–657PubMedCrossRef
3.
Baijens LW, Speyer R (2009) Effects of therapy for dysphagia in Parkinson’s disease: systematic review. Dysphagia 24:91–102PubMedCrossRef
4.
Barone JA (1999) Domperidone: a peripherally acting dopamine2-receptor antagonist. Ann Pharmacother 33:429–440PubMedCrossRef
5.
Benarroch EE, Schmeichel AM, Sandroni P, Low PA, Parisi JE (2006) Involvement of vagal autonomic nuclei in multiple system atrophy and Lewy body disease. Neurology 66:378–383PubMedCrossRef
6.
Berger Y, Blaivas JG, DeLaRocha ER, Salinas JM (1987) Urodynamic findings in Parkinson’s disease. J Urol 138:836–838PubMed
7.
Bleasdale-Barr KM, Mathias CJ (1998) Neck and other muscle pains in autonomic failure: their association with orthostatic hypotension. J R Soc Med 91:355–359PubMed
8.
Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K (2004) Stages in the development of Parkinson’s disease-related pathology. Cell Tissue Res 318:121–134PubMedCrossRef
9.
Chandiramani VA, Palace J, Fowler CJ (1997) How to recognize patients with parkinsonism who should not have urological surgery. Br J Urol 80:100–104PubMed
10.
Chaudhuri KR, Ellis C, Love-Jones S, Thomaides T, Clift S, Mathias CJ, Parkes JD (1997) Postprandial hypotension and parkinsonian state in Parkinson’s disease. Mov Disord 12:877–884PubMedCrossRef
11.
Djaldetti R, Baron J, Ziv I, Melamed E (1996) Gastric emptying in Parkinson’s disease: patients with and without response fluctuations. Neurology 46:1051–1054PubMed
12.
Edwards LL, Pfeiffer RF, Quigley EM, Hofman R, Balluff M (1991) Gastrointestinal symptoms in Parkinson’s disease. Mov Disord 6:151–156PubMedCrossRef
13.
Ekberg O, Hamdy S, Woisard V, Wuttge-Hannig A, Ortega P (2002) Social and psychological burden of dysphagia: its impact on diagnosis and treatment. Dysphagia 17:139–146PubMedCrossRef
14.
Freeman R (2008) Clinical practice. Neurogenic orthostatic hypotension. N Engl J Med 358:615–624PubMedCrossRef
15.
Friedenberg FK, Parkman HP (2007) Advances in the management of gastroparesis. Curr Treat Options Gastroenterol 10:283–293PubMedCrossRef
16.
Friedenberg FK, Parkman HP (2006) Delayed gastric emptying: whom to test, how to test, and what to do. Curr Treat Options Gastroenterol 9:295–304PubMedCrossRef
17.
Friedrich C, Rudiger H, Schmidt C, Herting B, Prieur S, Junghanns S, Schweitzer K, Globas C, Schols L, Berg D, Reichmann H, Ziemssen T (2010) Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes. Mov Disord 25:315–324PubMed
18.
Friedrich C, Rudiger H, Schmidt C, Herting B, Prieur S, Junghanns S, Schweitzer K, Globas C, Schols L, Berg D, Reichmann H, Ziemssen T (2008) Baroreflex sensitivity and power spectral analysis in different extrapyramidal syndromes. J Neural Transm 115:1527–1536PubMedCrossRef
19.
Goldstein DS, Holmes CS, Dendi R, Bruce SR, Li ST (2002) Orthostatic hypotension from sympathetic denervation in Parkinson’s disease. Neurology 58:1247–1255PubMed
20.
Goldstein DS, Pechnik S, Holmes C, Eldadah B, Sharabi Y (2003) Association between supine hypertension and orthostatic hypotension in autonomic failure. Hypertension 42:136–142PubMedCrossRef
21.
Hunter PC, Crameri J, Austin S, Woodward MC, Hughes AJ (1997) Response of parkinsonian swallowing dysfunction to dopaminergic stimulation. J Neurol Neurosurg Psychiatry 63:579–583PubMedCrossRef
22.
Hyson HC, Johnson AM, Jog MS (2002) Sublingual atropine for sialorrhea secondary to parkinsonism: a pilot study. Mov Disord 17:1318–1320PubMedCrossRef
23.
Jansen RW, Lipsitz LA (1995) Postprandial hypotension: epidemiology, pathophysiology, and clinical management. Ann Intern Med 122:286–295PubMed
24.
Jost WH (2003) Autonomic dysfunctions in idiopathic Parkinson’s disease. J Neurol 250 Suppl 1:I28–I30PubMed
25.
Jost WH, Schimrigk K (1997) Long-term results with cisapride in Parkinson’s disease. Mov Disord 12:423–425PubMedCrossRef
26.
Kaufmann H (1996) Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy. Clin Auton Res 6:125–126PubMedCrossRef
27.
Kimber J, Mathias CJ, Lees AJ, Bleasdale-Barr K, Chang HS, Churchyard A, Watson L (2000) Physiological, pharmacological and neurohormonal assessment of autonomic function in progressive supranuclear palsy. Brain 123(Pt 7):1422–1430PubMedCrossRef
28.
Kirchhof K, Apostolidis AN, Mathias CJ, Fowler CJ (2003) Erectile and urinary dysfunction may be the presenting features in patients with multiple system atrophy: a retrospective study. Int J Impot Res 15:293–298PubMedCrossRef
29.
Lamarre-Cliche M, Souich P, Champlain J, Larochelle P (2008) Pharmacokinetic and pharmacodynamic effects of midodrine on blood pressure, the autonomic nervous system, and plasma natriuretic peptides: a prospective, randomized, single-blind, two-period, crossover, placebo-controlled study. Clin Ther 30:1629–1638PubMedCrossRef
30.
Lemack GE, Dewey RB Jr, Roehrborn CG, O’Suilleabhain PE, Zimmern PE (2000) Questionnaire-based assessment of bladder dysfunction in patients with mild to moderate Parkinson’s disease. Urology 56:250–254PubMedCrossRef
31.
Lertxundi U, Peral J, Mora O, Domingo-Echaburu S, Martinez-Bengoechea MJ, Garcia-Monco JC (2008) Antidopaminergic therapy for managing comorbidities in patients with Parkinson’s disease. Am J Health Syst Pharm 65:414–419PubMedCrossRef
32.
Lewy FH (1913) Zur pathologischen Anatomie der Paralysis agitans. Dtsch Z Nervenheilk 50:50–55
33.
Lieberman AN, Horowitz L, Redmond P, Pachter L, Lieberman I, Leibowitz M (1980) Dysphagia in Parkinson’s disease. Am J Gastroenterol 74:157–160PubMed
34.
Logemann JA, Gensler G, Robbins J, Lindblad AS, Brandt D, Hind JA, Kosek S, Dikeman K, Kazandjian M, Gramigna GD, Lundy D, McGarvey-Toler S, Miller Gardner PJ (2008) A randomized study of three interventions for aspiration of thin liquids in patients with dementia or Parkinson’s disease. J Speech Lang Hear Res 51:173–183PubMedCrossRef
35.
Maranki J, Parkman HP (2007) Gastric electric stimulation for the treatment of gastroparesis. Curr Gastroenterol Rep 9:286–294PubMedCrossRef
36.
Mathias CJ, Senard JM, Braune S, Watson L, Aragishi A, Keeling JE, Taylor MD (2001) l-threo-dihydroxyphenylserine (l-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure. Clin Auton Res 11:235–242PubMedCrossRef
37.
Maule S, Papotti G, Naso D, Magnino C, Testa E, Veglio F (2007) Orthostatic hypotension: evaluation and treatment. Cardiovasc Hemato Disord Drug Targets 7:63–70
38.
McKee RF, McEnroe L, Anderson JH, Finlay IG (1999) Identification of patients likely to benefit from biofeedback for outlet obstruction constipation. Br J Surg 86:355–359PubMedCrossRef
39.
Micieli G, Tosi P, Marcheselli S, Cavallini A (2003) Autonomic dysfunction in Parkinson’s disease. Neurol Sci 24 Suppl 1:S32–S34PubMedCrossRef
40.
Naumann M, Jost W (2004) Botulinum toxin treatment of secretory disorders. Mov Disord 19 Suppl 8:S137–S141PubMedCrossRef
41.
Pal PK, Calne DB, Calne S, Tsui JK (2000) Botulinum toxin A as treatment for drooling saliva in PD. Neurology 54:244–247PubMed
42.
Papatsoris AG, Papapetropoulos S, Singer C, Deliveliotis C (2007) Urinary and erectile dysfunction in multiple system atrophy (MSA). Neurourol Urodyn
43.
Parkinson J (1817) An essay on shaking palsy. Sherwood, Neely and Jones, London
44.
Peralta C, Stampfer-Kountchev M, Karner E, Kollensperger M, Geser F, Wolf E, Seppi K, Benke T, Poewe W, Wenning GK (2007) Orthostatic hypotension and attention in Parkinson’s disease with and without dementia. J Neural Transm 114:585–588PubMedCrossRef
45.
Pfeiffer RF (2003) Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol 2:107–116PubMedCrossRef
46.
Pursiainen V, Haapaniemi TH, Korpelainen JT, Sotaniemi KA, Myllyla VV (2007) Sweating in Parkinsonian patients with wearing-off. Mov Disord 22:828–832PubMedCrossRef
47.
Rabine JC, Barnett JL (2001) Management of the patient with gastroparesis. J Clin Gastroenterol 32:11–18PubMedCrossRef
48.
Reichmann H, Ziemssen T (2009) Treatment strategies for nonmotor manifestations of Parkinson’s disease. Expert Opin Pharmacother 10:773–784PubMedCrossRef
49.
Reimann M, Schmidt C, Herting B, Prieur S, Junghanns S, Schweitzer K, Globas C, Schoels L, Reichmann H, Berg D, Ziemssen T (2010) Comprehensive autonomic assessment does not differentiate between Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy. J Neural Transm 117:69–76PubMedCrossRef
50.
Robertson D (2008) The pathophysiology and diagnosis of orthostatic hypotension. Clin Auton Res 18 Suppl 1:2–7PubMedCrossRef
51.
Robertson DR, Renwick AG, Macklin B, Jones S, Waller DG, George CF, Fleming JS (1992) The influence of levodopa on gastric emptying in healthy elderly volunteers. Eur J Clin Pharmacol 42:409–412PubMed
52.
Sage JI, Mark MH (1994) Basic mechanisms of motor fluctuations. Neurology 44:S10–S14PubMed
53.
Sakakibara R, Uchiyama T, Yamanishi T, Shirai K, Hattori T (2008) Bladder and bowel dysfunction in Parkinson’s disease. J Neural Transm 115:443–460PubMedCrossRef
54.
Schestatsky P, Valls-Sole J, Ehlers JA, Rieder CR, Gomes I (2006) Hyperhidrosis in Parkinson’s disease. Mov Disord 21:1744–1748PubMedCrossRef
55.
Schmidt C, Herting B, Prieur S, Junghanns S, Schweitzer K, Globas C, Schols L, Antoni S, Ferger D, Reichmann H, Wilhelm H, Berg D, Ziemssen T (2007) Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes. Mov Disord 22:2123–2126PubMedCrossRef
56.
Schmidt C, Herting B, Prieur S, Junghanns S, Schweitzer K, Globas C, Schöls L, Reichmann H, Berg D, Ziemssen T (2008) Autonomic dysfunction in different subtypes of multiple system atrophy. Mov Disord 23:1766–1772PubMedCrossRef
57.
Schmidt C, Herting B, Prieur S, Junghanns S, Schweitzer K, Globas C, Schöls L, Reichmann H, Berg D, Ziemssen T (2009) Loss of nocturnal blood pressure fall in various extrapyramidal syndromes. Mov Disord 24:2136–2142PubMedCrossRef
58.
Schmidt C, Herting B, Prieur S, Junghanns S, Schweitzer K, Globas C, Schöls L, Reichmann H, Berg D, Ziemssen T (2009) Valsalva manoeuvre in patients with extrapyramidal disease. J Neural Transm 116:875–880PubMedCrossRef
59.
Schmidt C, Herting B, Prieur S, Junghanns S, Schweitzer K, Reichmann H, Berg D, Ziemssen T (2008) Autonomic dysfunction in patients with progressive supranuclear palsy. Mov Disord 23:2083–2089PubMedCrossRef
60.
Shibao C, Gamboa A, Diedrich A, Biaggioni I (2006) Management of hypertension in the setting of autonomic dysfunction. Curr Treat Options Cardiovasc Med 8:105–109PubMedCrossRef
61.
Stocchi F, Badiali D, Vacca L, D’Alba L, Bracci F, Ruggieri S, Torti M, Berardelli A, Corazziari E (2000) Anorectal function in multiple system atrophy and Parkinson’s disease. Mov Disord 15:71–76PubMedCrossRef
62.
Swinn L, Schrag A, Viswanathan R, Bloem BR, Lees A, Quinn N (2003) Sweating dysfunction in Parkinson’s disease. Mov Disord 18:1459–1463PubMedCrossRef
63.
Visser M, Marinus J, Stiggelbout AM, Van Hilten JJ (2004) Assessment of autonomic dysfunction in Parkinson’s disease: the SCOPA-AUT. Mov Disord 19:1306–1312PubMedCrossRef
64.
Wakabayashi K, Takahashi H (2006) Cellular pathology in multiple system atrophy. Neuropathology 26:338–345PubMedCrossRef
65.
Wakabayashi K, Takahashi H, Ohama E, Takeda S, Ikuta F (1993) Lewy bodies in the visceral autonomic nervous system in Parkinson’s disease. Adv Neurol 60:609–612PubMed
66.
Yoshioka M, Oka H, Morita M, Inoue K (2003) [Sudomotor dysfunction in Parkinson’s disease]. Rinsho shinkeigaku = Clinical neurology 43:379-384
67.
Zangaglia R, Martignoni E, Glorioso M, Ossola M, Riboldazzi G, Calandrella D, Brunetti G, Pacchetti C (2007) Macrogol for the treatment of constipation in Parkinson’s disease. A randomized placebo-controlled study. Mov Disord 22:1239–1244PubMedCrossRef
68.
Ziemssen T, Reichmann H (2010) Cardiovascular autonomic dysfunction in Parkinson’s disease. J Neurol Sci 289:74–80PubMedCrossRef
69.
Ziemssen T, Reichmann H (2007) Non-motor dysfunction in Parkinson’s disease. Parkinsonism Relat Disord 13:323–332PubMedCrossRef
70.
Ziemssen T, Reichmann H (2010) Treatment of dysautonomia in extrapyramidal disorders. Ther Adv Neurol Disord 3:53–67PubMedCrossRef
71.
Ziemssen T, Schmidt C, Herting B, Reichmann H (2006) Autonomic dysfunction in Parkinson’s disease and Multiple System Atrophy. Akt Neurol 33:385–393CrossRef
Metadaten
Titel
Treatment of dysautonomia in extrapyramidal disorders
verfasst von
Tjalf Ziemssen
Gerd Fuchs
Wolfgang Greulich
Heinz Reichmann
Michael Schwarz
Birgit Herting
Publikationsdatum
01.05.2011
Verlag
Springer-Verlag
Erschienen in
Journal of Neurology / Ausgabe Sonderheft 2/2011
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-011-5946-8

Weitere Artikel der Sonderheft 2/2011

Journal of Neurology 2/2011 Zur Ausgabe

OriginalPaper

Stem cell-based therapies in Parkinson’s disease: future hope or current treatment option?

OriginalPaper

When Parkinson’s disease patients go to sleep: specific sleep disturbances related to Parkinson’s disease

OriginalPaper

Basic science in Parkinson’s disease: its impact on clinical practice

OriginalPaper

Parkinson’s disease risk score: moving to a premotor diagnosis

Editorial

Parkinson’s disease: a multi-faceted disease

OriginalPaper

Drug-induced impulse control disorders in Parkinson’s disease

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Stuhltransfusion könnte Fortschreiten von Parkinson-Symptomen bremsen

03.05.2024 Parkinson-Krankheit Nachrichten

Kann eine frühzeitige Stuhltransplantation das Fortschreiten von Parkinson-Symptomen verlangsamen? Die Ergebnisse einer randomisierten Phase-2-Studie scheinen dafür zu sprechen.

Frühe Tranexamsäure-Therapie nützt wenig bei Hirnblutungen

02.05.2024 Hirnblutung Nachrichten

Erhalten Personen mit einer spontanen Hirnblutung innerhalb von zwei Stunden nach Symptombeginn eine Tranexamsäure-Therapie, kann dies weder die Hämatomexpansion eindämmen noch die Mortalität senken.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders scheint das auf weibliche Kranke zuzutreffen, wie eine Studie zeigt.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise