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01.12.2015 | Original Communication

Morphometric changes in the reward system of Parkinson’s disease patients with impulse control disorders

verfasst von: Clelia Pellicano, Flavia Niccolini, Kit Wu, Sean S. O’Sullivan, Andrew D. Lawrence, Andrew J. Lees, Paola Piccini, Marios Politis

Erschienen in: Journal of Neurology | Ausgabe 12/2015

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Abstract

Impulse control disorders (ICDs) occur in a subset of patients with Parkinson’s disease (PD) who are receiving dopamine replacement therapy. In this study, we aimed to investigate structural abnormalities within the mesocortical and limbic cortices and subcortical structures in PD patients with ICDs. We studied 18 PD patients with ICDs, 18 PD patients without ICDs and a group of 24 age and sex-matched healthy controls. Cortical thickness (CTh) and subcortical nuclei volume analyses were carried out using the automated surface-based analysis package FreeSurfer (version 5.3.0). We found significant differences in MRI measures between the three groups. There was volume loss in the nucleus accumbens of both PD patients with ICDs and without ICDs compared to the control group. In addition, PD patients with ICDs showed significant atrophy in caudate, hippocampus and amygdala compared to the group of healthy controls. PD patients with ICDs had significant increased cortical thickness in rostral anterior cingulate cortex and frontal pole compared to PD patients without ICDs. Cortical thickness in rostral anterior cingulate and frontal pole was increased in PD patients with ICDs compared to the control group, but the differences failed to reach corrected levels of statistical significance. PD patients with ICDs showed increased cortical thickness in medial prefrontal regions. We speculate that these findings reflect either a pre-existing neural trait vulnerability to impulsivity or the expression of a maladaptive synaptic plasticity under non-physiological dopaminergic stimulation.

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Titel: Morphometric changes in the reward system of Parkinson’s disease patients with impulse control disorders
verfasst von: Clelia Pellicano
Flavia Niccolini
Kit Wu
Sean S. O’Sullivan
Andrew D. Lawrence
Andrew J. Lees
Paola Piccini
Marios Politis
Publikationsdatum: 01.12.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 12/2015
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-015-7892-3

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