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International Archives of Occupational and Environmental Health

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01.05.2012 | Review

Occupational exposures to asbestos, polycyclic aromatic hydrocarbons and solvents, and cancers of the oral cavity and pharynx: a quantitative literature review

verfasst von: Sophie Paget-Bailly, Diane Cyr, Danièle Luce

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 4/2012

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Abstract

Purpose

The role of occupational risk factors in oral and pharyngeal cancer is not well known and is possibly underestimated. This quantitative review summarizes epidemiological findings on exposure to asbestos, polycyclic aromatic hydrocarbons and solvents, and cancers of the oral cavity and pharynx.

Methods

A systematic literature search was performed. We analyzed 63 publications: 8 from case–control studies and 55 from cohort studies. For agents with at least five available studies with homogenous exposure, a series of meta-analyses was conducted to provide quantitative pooled estimates of risks, using random effect models.

Results

Exposure to asbestos (meta-RR 1.25; 95% CI 1.10–1.42) and to polycyclic aromatic hydrocarbons (meta-RR 1.14; 95% CI 1.02–1.28) was found to be associated with oral and pharyngeal cancer risk. On the other hand, no association was found with exposure to solvents in general (meta-RR 0.98; 95% CI 0.77–1.23) but the strong heterogeneity between studies suggested differences in exposures. The small number of studies with homogeneous exposure did not allow meta-analyses for specific solvents.

Conclusions

Future investigations should overcome common weaknesses of past studies, in terms of sample size, characterization of exposure, and classification of cancer sites.

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Behrens T, Schill W, Ahrens W (2009) Elevated cancer mortality in a German cohort of bitumen workers: extended follow-up through 2004. J Occup Environ Hyg 6:555–561CrossRef

Berrino F, Richiardi L, Boffetta P, Esteve J, Belletti I, Raymond L, Troschel L, Pisani P, Zubiri L, Ascunce N, Guberan E, Tuyns A, Terracini B, Merletti F (2003) Occupation and larynx and hypopharynx cancer: a job-exposure matrix approach in an international case-control study in France, Italy, Spain and Switzerland. Cancer Causes Control 14:213–223CrossRef

Blair A, Hartge P, Stewart PA, McAdams M, Lubin J (1998) Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow up. Occup Environ Med 55:161–171CrossRef

Boffetta P, Burstyn I, Partanen T, Kromhout H, Svane O, Langard S, Jarvholm B, Frentzel-Beyme R, Kauppinen T, Stucker I, Shaham J, Heederik D, Ahrens W, Bergdahl IA, Cenee S, Ferro G, Heikkila P, Hooiveld M, Johansen C, Randem BG, Schill W (2003) Cancer mortality among European asphalt workers: an international epidemiological study. I. Results of the analysis based on job titles. Am J Ind Med 43:18–27CrossRef

Boice JD Jr, Marano DE, Fryzek JP, Sadler CJ, McLaughlin JK (1999) Mortality among aircraft manufacturing workers. Occup Environ Med 56:581–597CrossRef

Boice JD Jr, Marano DE, Cohen SS, Mumma MT, Blot WJ, Brill AB, Fryzek JP, Henderson BE, McLaughlin JK (2006) Mortality among Rocketdyne workers who tested rocket engines, 1948–1999. J Occup Environ Med 48:1070–1092CrossRef

Bosetti C, Boffetta P, La VC (2007) Occupational exposures to polycyclic aromatic hydrocarbons, and respiratory and urinary tract cancers: a quantitative review to 2005. Ann Oncol 18:431–446CrossRef

Chang YM, Tai CF, Yang SC, Lin RS, Sung FC, Shih TS, Liou SH (2005) Cancer incidence among workers potentially exposed to chlorinated solvents in an electronics factory. J Occup Health 47:171–180CrossRef

Coble JB, Brown LM, Hayes RB, Huang WY, Winn DM, Gridley G, Bravo-Otero E, Fraumeni JF Jr (2003) Sugarcane farming, occupational solvent exposures, and the risk of oral cancer in Puerto Rico. J Occup Environ Med 45:869–874CrossRef

Conway DI, McKinney PA, McMahon AD, Ahrens W, Schmeisser N, Benhamou S, Bouchardy C, Macfarlane GJ, Macfarlane TV, Lagiou P, Minaki P, Bencko V, Holcatova I, Merletti F, Richiardi L, Kjaerheim K, Agudo A, Castellsague X, Talamini R, Barzan L, Canova C, Simonato L, Lowry RJ, Znaor A, Healy CM, McCartan BE, Marron M, Hashibe M, Brennan P (2010) Socioeconomic factors associated with risk of upper aerodigestive tract cancer in Europe. Eur J Cancer 46:588–598CrossRef

Dement J, Welch L, Haile E, Myers D (2009a) Mortality among sheet metal workers participating in a medical screening program. Am J Ind Med 52:603–613CrossRef

Dement JM, Ringen K, Welch LS, Bingham E, Quinn P (2009b) Mortality of older construction and craft workers employed at Department of Energy (DOE) nuclear sites. Am J Ind Med 52:671–682CrossRef

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188CrossRef

Donato F, Monarca S, Marchionna G, Rossi A, Cicioni C, Chiesa R, Colin D, Boffetta P (2000) Mortality from cancer and chronic respiratory diseases among workers who manufacture carbon electrodes. Occup Environ Med 57:484–487CrossRef

D’Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML (2007) Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 356:1944–1956CrossRef

Egger M, Davey SG, Schneider M, Minder C (1997a) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634CrossRef

Egger M, Zellweger-Zähner T, Schneider M, Junker C, Lengeler C, Antes G (1997b) Language bias in randomised controlled trials published in English and German. Lancet 350:326–329CrossRef

Enterline PE, Hartley J, Henderson V (1987) Asbestos and cancer: a cohort followed up to death. Br J Ind Med 44:396–401

Evanoff BA, Gustavsson P, Hogstedt C (1993) Mortality and incidence of cancer in a cohort of Swedish chimney sweeps: an extended follow up study. Br J Ind Med 50:450–459

Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer

Giaroli C, Beeli S, Bruno C, Candela S, Grignoli M, Minisci S, Poletti R, Ricco G, Vecchi G, Venturi G, Ziccardi A, Comba P (1994) Mortality study of asbestos cement workers. Int Arch Occup Environ Health 66:7–11CrossRef

Gibbs GW, Sevigny M (2007) Mortality and cancer experience of Quebec aluminum reduction plant workers, part 4: cancer incidence. J Occup Environ Med 49:1351–1366CrossRef

Goodman M, Morgan RW, Ray R, Malloy CD, Zhao K (1999) Cancer in asbestos-exposed occupational cohorts: a meta-analysis. Cancer Causes Control 10:453–465CrossRef

Gustavsson P, Jakobsson R, Johansson H, Lewin F, Norell S, Rutkvist LE (1998) Occupational exposures and squamous cell carcinoma of the oral cavity, pharynx, larynx, and oesophagus: a case-control study in Sweden. Occup Environ Med 55:393–400CrossRef

Hansen ES (1989) Cancer incidence in an occupational cohort exposed to bitumen fumes. Scand J Work Environ Health 15:101–105CrossRef

Harding AH, Darnton A, Wegerdt J, McElvenny D (2009) Mortality among British asbestos workers undergoing regular medical examinations (1971–2005). Occup Environ Med 66:487–495CrossRef

Hashibe M, Brennan P, Chuang SC, Boccia S, Castellsague X, Chen C, Curado MP, Dal ML, Daudt AW, Fabianova E, Fernandez L, Wunsch-Filho V, Franceschi S, Hayes RB, Herrero R, Kelsey K, Koifman S, La VC, Lazarus P, Levi F, Lence JJ, Mates D, Matos E, Menezes A, McClean MD, Muscat J, Eluf-Neto J, Olshan AF, Purdue M, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn DM, Shangina O, Pilarska A, Zhang ZF, Ferro G, Berthiller J, Boffetta P (2009) Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev 18:541–550CrossRef

Hein MJ, Stayner LT, Lehman E, Dement JM (2007) Follow-up study of chrysotile textile workers: cohort mortality and exposure-response. Occup Environ Med 64:616–625CrossRef

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560CrossRef

Hoshuyama T, Pan G, Tanaka C, Feng Y, Yu L, Liu T, Liu L, Hanaoka T, Takahashi K (2006) Mortality of iron-steel workers in Anshan, China: a retrospective cohort study. Int J Occup Environ Health 12:193–202

Huebner WW, Schoenberg JB, Kelsey JL, Wilcox HB, McLaughlin JK, Greenberg RS, Preston-Martin S, Austin DF, Stemhagen A, Blot WJ (1992) Oral and pharyngeal cancer and occupation: a case-control study. Epidemiology 3:300–309CrossRef

Hughes JM, Weill H, Hammad YY (1987) Mortality of workers employed in two asbestos cement manufacturing plants. Br J Ind Med 44:161–174

Hurley JF, Archibald RM, Collings PL, Fanning DM, Jacobsen M, Steele RC (1983) The mortality of coke workers in Britain. Am J Ind Med 4:691–704CrossRef

Jones DR, Sutton AJ, Abrams KR, Fenty J, Warren F, Rushton L (2009) Systematic review and meta-analysis of mortality in crop protection product manufacturing workers. Occup Environ Med 66:7–15CrossRef

Karlehagen S, Andersen A, Ohlson CG (1992) Cancer incidence among creosote-exposed workers. Scand J Work Environ Health 18:26–29CrossRef

Krstev S, Stewart P, Rusiecki J, Blair A (2007) Mortality among shipyard Coast Guard workers: a retrospective cohort study. Occup Environ Med 64:651–658CrossRef

Lehman EJ, Hein MJ (2006) Mortality of workers employed in shoe manufacturing: an update. Am J Ind Med 49:535–546CrossRef

Levi F, Pasche C, La VC, Lucchini F, Franceschi S, Monnier P (1998) Food groups and risk of oral and pharyngeal cancer. Int J Cancer 77:705–709CrossRef

Levin JL, McLarty JW, Hurst GA, Smith AN, Frank AL (1998) Tyler asbestos workers: mortality experience in a cohort exposed to amosite. Occup Environ Med 55:155–160CrossRef

Lipworth L, La VC, Bosetti C, McLaughlin JK (2009) Occupational exposure to rock wool and glass wool and risk of cancers of the lung and the head and neck: a systematic review and meta-analysis. J Occup Environ Med 51:1075–1087CrossRef

Loomis D, Dement JM, Wolf SH, Richardson DB (2009) Lung cancer mortality and fibre exposures among North Carolina asbestos textile workers. Occup Environ Med 66:535–542CrossRef

Marchand JL, Luce D, Leclerc A, Goldberg P, Orlowski E, Bugel I, Brugere J (2000) Laryngeal and hypopharyngeal cancer and occupational exposure to asbestos and man-made vitreous fibers: results of a case-control study. Am J Ind Med 37:581–589CrossRef

Menvielle G, Luce D, Goldberg P, Leclerc A (2004) Smoking, alcohol drinking, occupational exposures and social inequalities in hypopharyngeal and laryngeal cancer. Int J Epidemiol 33:799–806CrossRef

Merletti F, Boffetta P, Ferro G, Pisani P, Terracini B (1991) Occupation and cancer of the oral cavity or oropharynx in Turin, Italy. Scand J Work Environ Health 17:248–254CrossRef

Merlo DF, Garattini S, Gelatti U, Simonati C, Covolo L, Ceppi M, Donato F (2004) A mortality cohort study among workers in a graphite electrode production plant in Italy. Occup Environ Med 61:e9CrossRef

Moulin JJ, Mur JM, Wild P, Demonchy A, Eloy E, Jeannot A (1988) Epidemiologic study of the mortality among the employees of a coal tar distillery. Rev Epidemiol Sante Publ 36:99–107

Moulin JJ, Clavel T, Buclez B, Laffitte-Rigaud G (2000a) A mortality study among workers in a French aluminium reduction plant. Int Arch Occup Environ Health 73:323–330CrossRef

Moulin JJ, Clavel T, Roy D, Dananche B, Marquis N, Fevotte J, Fontana JM (2000b) Risk of lung cancer in workers producing stainless steel and metallic alloys. Int Arch Occup Environ Health 73:171–180CrossRef

Mundt KA, Birk T, Burch MT (2003) Critical review of the epidemiological literature on occupational exposure to perchloroethylene and cancer. Int Arch Occup Environ Health 76:473–491CrossRef

Nokso-Koivisto P, Pukkala E (1994) Past exposure to asbestos and combustion products and incidence of cancer among Finnish locomotive drivers. Occup Environ Med 51:330–334CrossRef

Parnes SM (1990) Asbestos and cancer of the larynx: is there a relationship? Laryngoscope 100:254–261CrossRef

Pira E, Pelucchi C, Piolatto PG, Negri E, Discalzi G, La VC (2007) First and subsequent asbestos exposures in relation to mesothelioma and lung cancer mortality. Br J Cancer 97:1300–1304CrossRef

Pira E, Pelucchi C, Piolatto PG, Negri E, Bilei T, La VC (2009) Mortality from cancer and other causes in the Balangero cohort of chrysotile asbestos miners. Occup Environ Med 66:805–809CrossRef

Pukkala E, Martinsen JI, Lynge E, Gunnarsdottir HK, Sparen P, Tryggvadottir L, Weiderpass E, Kjaerheim K (2009) Occupation and cancer—follow-up of 15 million people in five Nordic countries. Acta Oncol 48:646–790CrossRef

Puntoni R, Merlo F, Borsa L, Reggiardo G, Garrone E, Ceppi M (2001) A historical cohort mortality study among shipyard workers in Genoa, Italy. Am J Ind Med 40:363–370

Purdue MP, Jarvholm B, Bergdahl IA, Hayes RB, Baris D (2006) Occupational exposures and head and neck cancers among Swedish construction workers. Scand J Work Environ Health 32:270–275CrossRef

Raaschou-Nielsen O, Hansen J, McLaughlin JK, Kolstad H, Christensen JM, Tarone RE, Olsen JH (2003) Cancer risk among workers at Danish companies using trichloroethylene: a cohort study. Am J Epidemiol 158:1182–1192CrossRef

Raffn E, Lynge E, Juel K, Korsgaard B (1989) Incidence of cancer and mortality among employees in the asbestos cement industry in Denmark. Br J Ind Med 46:90–96

Reid A, Ambrosini G, de Klerk N, Fritschi L, Musk B (2004) Aerodigestive and gastrointestinal tract cancers and exposure to crocidolite (blue asbestos): incidence and mortality among former crocidolite workers. Int J Cancer 111:757–761CrossRef

Ruder AM, Ward EM, Dong M, Okun AH, vis-King K (2004) Mortality patterns among workers exposed to styrene in the reinforced plastic boatbuilding industry: an update. Am J Ind Med 45:165–176CrossRef

Schildt EB, Eriksson M, Hardell L, Magnuson A (1999) Occupational exposures as risk factors for oral cancer evaluated in a Swedish case-control study. Oncol Rep 6:317–320

Shangina O, Brennan P, Szeszenia-Dabrowska N, Mates D, Fabianova E, Fletcher T, Mannetje A, Boffetta P, Zaridze D (2006) Occupational exposure and laryngeal and hypopharyngeal cancer risk in central and eastern Europe. Am J Epidemiol 164:367–375CrossRef

Sherson D, Svane O, Lynge E (1991) Cancer incidence among foundry workers in Denmark. Arch Environ Health 46:75–81CrossRef

Sim MR, Del MA, Hoving JL, Macfarlane E, McKenzie D, Benke G, de Klerk N, Fritschi L (2009) Mortality and cancer incidence in workers in two Australian prebake aluminium smelters. Occup Environ Med 66:464–470CrossRef

Sluis-Cremer GK, Liddell FD, Logan WP, Bezuidenhout BN (1992) The mortality of amphibole miners in South Africa, 1946–80. Br J Ind Med 49:566–575

Sorahan T, Faux AM, Cooke MA (1994) Mortality among a cohort of United Kingdom steel foundry workers with special reference to cancers of the stomach and lung, 1946–1990. Occup Environ Med 51:316–322CrossRef

Sorahan T, Hamilton L, van Tongeren M, Gardiner K, Harrington JM (2001) A cohort mortality study of U.K. carbon black workers, 1951–1996. Am J Ind Med 39:158–170CrossRef

Spinelli JJ, Demers PA, Le ND, Friesen MD, Lorenzi MF, Fang R, Gallagher RP (2006) Cancer risk in aluminum reduction plant workers (Canada). Cancer Causes Control 17:939–948CrossRef

Straif K, Baan R, Grosse Y, Secretan B, El GF, Cogliano V (2005) Carcinogenicity of polycyclic aromatic hydrocarbons. Lancet Oncol 6:931–932CrossRef

Straif K, brahim-Tallaa L, Baan R, Grosse Y, Secretan B, El GF, Bouvard V, Guha N, Freeman C, Galichet L, Cogliano V (2009) A review of human carcinogens—part C: metals, arsenic, dusts, and fibres. Lancet Oncol 10:453–454CrossRef

Strand LA, Martinsen JI, Koefoed VF, Sommerfelt-Pettersen J, Grimsrud TK (2010) Asbestos-related cancers among 28, 300 military servicemen in the Royal Norwegian Navy. Am J Ind Med 53:64–71

Swaen GM, Slangen JM (1997) Mortality in a group of tar distillery workers and roofers. Int Arch Occup Environ Health 70:133–137CrossRef

Swaen GM, Slangen JJ, Volovics A, Hayes RB, Scheffers T, Sturmans F (1991) Mortality of coke plant workers in The Netherlands. Br J Ind Med 48:130–135

Tarvainen L, Kyyronen P, Kauppinen T, Pukkala E (2008) Cancer of the mouth and pharynx, occupation and exposure to chemical agents in Finland [in 1971–95]. Int J Cancer 123:653–659CrossRef

Teta MJ, Ott MG, Schnatter AR (1987) Population based mortality surveillance in carbon products manufacturing plants. Br J Ind Med 44:344–350

Tsai SP, Ahmed FS, Wendt JK, Foster DE, Donnelly RP, Strawmyer TR (2007) A 56-year mortality follow-up of Texas petroleum refinery and chemical employees, 1948–2003. J Occup Environ Med 49:557–567CrossRef

Ulvestad B, Kjaerheim K, Martinsen JI, Damberg G, Wannag A, Mowe G, Andersen A (2002) Cancer incidence among workers in the asbestos-cement producing industry in Norway. Scand J Work Environ Health 28:411–417CrossRef

Ulvestad B, Kjaerheim K, Martinsen JI, Mowe G, Andersen A (2004) Cancer incidence among members of the Norwegian trade union of insulation workers. J Occup Environ Med 46:84–89CrossRef

Ward EM, Ruder AM, Suruda A, Smith AB, Halperin W, Fessler CA, Zahm SH (1994) Cancer mortality patterns among female and male workers employed in a cable manufacturing plant during World War II. J Occup Med 36:860–866CrossRef

Wartenberg D, Reyner D, Scott CS (2000) Trichloroethylene and cancer: epidemiologic evidence. Environ Health Perspect 108(Suppl 2):161–176

Wellmann J, Weiland SK, Neiteler G, Klein G, Straif K (2006) Cancer mortality in German carbon black workers 1976–1998. Occup Environ Med 63:513–521CrossRef

Wong O, Harris F (2005) Retrospective cohort mortality study and nested case-control study of workers exposed to creosote at 11 wood-treating plants in the United States. J Occup Environ Med 47:683–697CrossRef

Titel: Occupational exposures to asbestos, polycyclic aromatic hydrocarbons and solvents, and cancers of the oral cavity and pharynx: a quantitative literature review
verfasst von: Sophie Paget-Bailly
Diane Cyr
Danièle Luce
Publikationsdatum: 01.05.2012
Verlag: Springer-Verlag
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 4/2012
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-011-0683-y

Springer Medizin

Abstract

Purpose

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Results

Conclusions

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