Erschienen in:
30.01.2016 | Original Article
Sleep in children with attention-deficit/hyperactivity disorder (ADHD) before and after 6-month treatment with methylphenidate: a pilot study
verfasst von:
Piernanda Vigliano, Giovanni Battista Galloni, Irene Bagnasco, Giuliana Delia, Alessandra Moletto, Mauro Mana, Samuele Cortese
Erschienen in:
European Journal of Pediatrics
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Ausgabe 5/2016
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Abstract
Children with ADHD may present with sleep disturbances that add to the impairment of the disorder. The long-term sleep effects of the first-line pharmacological treatment for ADHD, i.e., psychostimulants, are unclear. In this pilot study, we compared polysomnographic variables in children with ADHD (n = 11, aged 6–15 years), before pharmacological treatment, and in children without ADHD (n = 22, aged 5–14 years); we also assessed polysomnographic changes in children with ADHD (n = 7) after a 6-month treatment with methylphenidate immediate-release (once or twice daily). Compared to children without ADHD, those with ADHD at baseline presented with significantly increased duration of awakenings (p = 0.02), reduction in sleep efficiency (p = 0.03), and increase in stage I (N1) (p < 0.01) and reduction in stage II (N2) (p = 0.02) and stage III–IV (N3) percentages. Methylphenidate treatment did not significantly change any parameter of sleep architecture.
Conclusion: Preliminary evidence from this pilot study shows that, compared to children without ADHD, those with ADHD presented a more fragmented and less effective sleep at baseline and that the 6-month methylphenidate treatment did not further negatively impact on sleep architecture.
What is known:
• Children with ADHD may present with subjectively reported and/or objectively confirmed disturbances of sleep.
• The long-term effects on sleep of the first-line pharmacological treatment for ADHD, i.e., psychostimulants, are not clear.
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What is new:
• Our study showed that the 6-month continuous treatment with methylphenidate did not further negatively impact on sleep architecture in children with ADHD.
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