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Erschienen in: Supportive Care in Cancer 8/2004

01.08.2004 | Original Article

Decreased taste sensitivity in cancer patients under chemotherapy

verfasst von: M. V. Berteretche, A. M. Dalix, A. M. Cesar d’Ornano, F. Bellisle, D. Khayat, A. Faurion

Erschienen in: Supportive Care in Cancer | Ausgabe 8/2004

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Abstract

Goals of work

The aim of the study was to measure taste thresholds among cancer patients under chemotherapy compared to controls.

Patients and methods

The study was performed with 110 cancer patients and 170 healthy subjects of similar age distribution were included in the study. The electrogustometric detection threshold was evaluated as the lowest current intensity perceived by the subject in three tongue sites independently with a constant current generator.

Main results

Taste thresholds for all cancer patients demonstrated significantly higher values compared to controls.

Conclusions

Cancer patients treated by chemotherapy demonstrated a temporary taste sensitivity deficit. Associated with the illness due to the treatment, this deficit explains the patients complaining of “abnormal or bad tastes”, which results in food aversion and has a negative impact on nutritional status and quality of life. In order to prevent the risk of anorexia and the enhanced morbidity related to this deficit, treatment should include relevant information to the subject for anticipating objective taste modifications and a psychological follow-up during the actual change of taste quality perceptions in everyday life.
Literatur
1.
Zurück zum Zitat Bartoshuk LM (1990) Chemosensory alterations and cancer therapies. NCI Monogr 9:179–184PubMed Bartoshuk LM (1990) Chemosensory alterations and cancer therapies. NCI Monogr 9:179–184PubMed
2.
3.
Zurück zum Zitat Beidler LM, Smith JC (1991) Effects of radiation therapy and drugs on cell turnover and taste. In: Getchell TV et al (eds) Smell and taste in health and disease. Raven, New York, pp 753–763 Beidler LM, Smith JC (1991) Effects of radiation therapy and drugs on cell turnover and taste. In: Getchell TV et al (eds) Smell and taste in health and disease. Raven, New York, pp 753–763
4.
Zurück zum Zitat Bernstein IL (1978) Learned taste aversions in children receiving chemotherapy Science 200:1302–1303 Bernstein IL (1978) Learned taste aversions in children receiving chemotherapy Science 200:1302–1303
5.
Zurück zum Zitat Bernstein IL, Treneer CM, Goehler LE, Murowchick E (1985) Tumor growth in rats: conditioned suppression of food intake and preference. Behav Neurosci 99:818–830CrossRefPubMed Bernstein IL, Treneer CM, Goehler LE, Murowchick E (1985) Tumor growth in rats: conditioned suppression of food intake and preference. Behav Neurosci 99:818–830CrossRefPubMed
6.
Zurück zum Zitat Buntzel J, Glatzel M, Kuttner K, Weinaug R, Frohlich D (2002) Amifostine in simultaneous radiochemotherapy of advanced head and neck cancer. Semin Radiat Oncol 12:4–13CrossRefPubMed Buntzel J, Glatzel M, Kuttner K, Weinaug R, Frohlich D (2002) Amifostine in simultaneous radiochemotherapy of advanced head and neck cancer. Semin Radiat Oncol 12:4–13CrossRefPubMed
7.
Zurück zum Zitat Comeau TB, Epstein JB, Migas C (2001) Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge. Support Care Cancer 9:575–580CrossRefPubMed Comeau TB, Epstein JB, Migas C (2001) Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge. Support Care Cancer 9:575–580CrossRefPubMed
8.
Zurück zum Zitat Frank ME, Smith DV (1991) Electrogustometry: a simple way to test taste. In: Getchell TV et al (eds) Smell and taste in health and disease. Raven, New York, pp 503–514 Frank ME, Smith DV (1991) Electrogustometry: a simple way to test taste. In: Getchell TV et al (eds) Smell and taste in health and disease. Raven, New York, pp 503–514
9.
Zurück zum Zitat Frank ME, Hettinger TP, Herness MS, Pfaffman C (1986) Evaluation of taste function by electrogustometry. In: Meiselman HL, Rivlin RS (eds) Clinical measurement of taste and smell. Macmillan, New York, pp 187–199 Frank ME, Hettinger TP, Herness MS, Pfaffman C (1986) Evaluation of taste function by electrogustometry. In: Meiselman HL, Rivlin RS (eds) Clinical measurement of taste and smell. Macmillan, New York, pp 187–199
10.
Zurück zum Zitat Ganchrow JR, Ganchrow D, Royer SM, Kinnamon JC (1993) Aspects of vertebrate gustatory phylogeny: morphology and turnover of chick taste bud cells. Microsc Res Tech 26:106–119PubMed Ganchrow JR, Ganchrow D, Royer SM, Kinnamon JC (1993) Aspects of vertebrate gustatory phylogeny: morphology and turnover of chick taste bud cells. Microsc Res Tech 26:106–119PubMed
11.
Zurück zum Zitat Herness MS (1985) Neurophysiological and biophysical evidence on the mechanism of electric taste. J Gen Physiol 86:59–87CrossRefPubMed Herness MS (1985) Neurophysiological and biophysical evidence on the mechanism of electric taste. J Gen Physiol 86:59–87CrossRefPubMed
12.
Zurück zum Zitat Holmes S (1993) Food avoidance in patients undergoing cancer chemotherapy. Support Care Cancer 1:326–330PubMed Holmes S (1993) Food avoidance in patients undergoing cancer chemotherapy. Support Care Cancer 1:326–330PubMed
13.
Zurück zum Zitat Le Floch JP, Le Lievre G, Verroust J, Philippon C, Peynegre R, Perlemutter L (1990) Factors related to the electric taste threshold in type 1 diabetic patients. Diabet Med 7:526–531PubMed Le Floch JP, Le Lievre G, Verroust J, Philippon C, Peynegre R, Perlemutter L (1990) Factors related to the electric taste threshold in type 1 diabetic patients. Diabet Med 7:526–531PubMed
14.
Zurück zum Zitat Mattes RD (1994) Prevention of food aversions in cancer patients during treatment. Nutr Cancer 21:13–24PubMed Mattes RD (1994) Prevention of food aversions in cancer patients during treatment. Nutr Cancer 21:13–24PubMed
15.
Zurück zum Zitat Mattes RD, Arnold C, Boraas M (1987) Learned food aversions among cancer chemotherapy patients. Cancer 60:2576–2580PubMed Mattes RD, Arnold C, Boraas M (1987) Learned food aversions among cancer chemotherapy patients. Cancer 60:2576–2580PubMed
16.
Zurück zum Zitat Mattes RD, Curran WJ, Alavi J, Powlis W, Whittington R (1992) Clinical implications of learned food aversions in patients with cancer treated with chemotherapy or radiation therapy. Cancer 70:192–200PubMed Mattes RD, Curran WJ, Alavi J, Powlis W, Whittington R (1992) Clinical implications of learned food aversions in patients with cancer treated with chemotherapy or radiation therapy. Cancer 70:192–200PubMed
17.
Zurück zum Zitat Miller SL, Mirza N, Doty RL (2002) Electrogustometric thresholds: relationship to anterior tongue locus, area of stimulation, and number of fungiform papillae. Physiology & Behavior 75:753–757 Miller SL, Mirza N, Doty RL (2002) Electrogustometric thresholds: relationship to anterior tongue locus, area of stimulation, and number of fungiform papillae. Physiology & Behavior 75:753–757
18.
Zurück zum Zitat Mojet J, Christ-Hazelhof E, Heidema J (2001) Taste perception with age: generic or specific losses in threshold sensitivity to the five basic tastes? Chem Senses 26:845–860CrossRefPubMed Mojet J, Christ-Hazelhof E, Heidema J (2001) Taste perception with age: generic or specific losses in threshold sensitivity to the five basic tastes? Chem Senses 26:845–860CrossRefPubMed
19.
Zurück zum Zitat Ninomiya Y, Mizukoshi T, Nishikawa T, Funakoshi M (1987) Ion specificity of rat chorda tympani fibers to chemical and electrical tongue stimulations. Brain Res 404:350–354CrossRefPubMed Ninomiya Y, Mizukoshi T, Nishikawa T, Funakoshi M (1987) Ion specificity of rat chorda tympani fibers to chemical and electrical tongue stimulations. Brain Res 404:350–354CrossRefPubMed
20.
Zurück zum Zitat Oakley B (1974) On the specification of taste neurons in the rat tongue. Brain Res 75: 85–96CrossRefPubMed Oakley B (1974) On the specification of taste neurons in the rat tongue. Brain Res 75: 85–96CrossRefPubMed
21.
Zurück zum Zitat Ovesen L, Sorensen M, Hannibal J, Allingstrup L (1991) Electrical taste detection thresholds and chemical smell detection thresholds in patients with cancer. Cancer 68:2260–2265PubMed Ovesen L, Sorensen M, Hannibal J, Allingstrup L (1991) Electrical taste detection thresholds and chemical smell detection thresholds in patients with cancer. Cancer 68:2260–2265PubMed
22.
Zurück zum Zitat Rhodes VA, McDaniel RW, Hanson B, Markway E, Johnson M (1994) Sensory perception of patients on selected antineoplastic chemotherapy protocols. Cancer Nursing 17:45–51PubMed Rhodes VA, McDaniel RW, Hanson B, Markway E, Johnson M (1994) Sensory perception of patients on selected antineoplastic chemotherapy protocols. Cancer Nursing 17:45–51PubMed
23.
Zurück zum Zitat Rozin P (1968) Specific aversion and neophobia resulting from vitamin deficiencies or poisoning in half wild and domestic rats. J Comp Physiol Psychol 66:82–88PubMed Rozin P (1968) Specific aversion and neophobia resulting from vitamin deficiencies or poisoning in half wild and domestic rats. J Comp Physiol Psychol 66:82–88PubMed
24.
Zurück zum Zitat Schiffman S (1983). Taste and smell in disease. N Engl J Med 308:1337–1342PubMed Schiffman S (1983). Taste and smell in disease. N Engl J Med 308:1337–1342PubMed
25.
Zurück zum Zitat Schiffman S (1991) Drugs influencing taste and smell perception. In: Getchell TV et al (eds) Smell and taste in health and disease. Raven, New York, pp 845–850 Schiffman S (1991) Drugs influencing taste and smell perception. In: Getchell TV et al (eds) Smell and taste in health and disease. Raven, New York, pp 845–850
26.
Zurück zum Zitat Shils ME (1977) Nutritional problems induced by cancer. Med Clin North Am 63:1009–1025 Shils ME (1977) Nutritional problems induced by cancer. Med Clin North Am 63:1009–1025
27.
Zurück zum Zitat Tomita H, Ikeda M (2002) Clinical use of electrogustometry: strengths and limitations Acta Otolaryngol [Suppl] 546:27–38 Tomita H, Ikeda M (2002) Clinical use of electrogustometry: strengths and limitations Acta Otolaryngol [Suppl] 546:27–38
28.
Zurück zum Zitat Wickham RS, Rehwaldt M, Kefer C, Shott S, Abbas K, Glynn-Tucker E, Potter C, Blendowski C (1999) Taste changes experienced by patients receiving chemotherapy. Oncol Nurs Forum 26:697–706PubMed Wickham RS, Rehwaldt M, Kefer C, Shott S, Abbas K, Glynn-Tucker E, Potter C, Blendowski C (1999) Taste changes experienced by patients receiving chemotherapy. Oncol Nurs Forum 26:697–706PubMed
Metadaten
Titel
Decreased taste sensitivity in cancer patients under chemotherapy
verfasst von
M. V. Berteretche
A. M. Dalix
A. M. Cesar d’Ornano
F. Bellisle
D. Khayat
A. Faurion
Publikationsdatum
01.08.2004
Verlag
Springer-Verlag
Erschienen in
Supportive Care in Cancer / Ausgabe 8/2004
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-004-0589-2

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