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Supportive Care in Cancer

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01.01.2011 | Original Article

Radiodermatitis prevention with sucralfate in breast cancer: fundamental and clinical studies

verfasst von: Sabrina Falkowski, Patrick Trouillas, Jean-Luc Duroux, Jean-Marie Bonnetblanc, Pierre Clavère

Erschienen in: Supportive Care in Cancer | Ausgabe 1/2011

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Abstract

Background

Acute radiodermatitis induced by radiotherapy may affect the quality of life and in some cases requires withholding treatment. The present study concerns the protective effect of a 1% sucralfate lotion. We propose joint fundamental and clinical points of view.

Methods

The free radical scavenging capacity of sucralfate was measured with electron spin resonance and was supported by theoretical calculations. The clinical effects of sucralfate lotion were evaluated on 21 women treated for breast cancer. Breast skin response was evaluated at 0, 10, 20, 30, 40, and 50 Gy, according to (1) the radiation therapy oncology group (RTOG) acute toxicity scale and (2) spectrophotometry data obtained with X-Rite SP60.

Results and conclusions

Sucralfate appeared as a relatively poor free radical scavenger (compared to reference compounds such as vitamin E). The sucralfate-containing lotion used in the present study did not provide systematic radiodermatitis prevention. Spectrophotometric evaluation of the skin response to irradiation appeared to be a very effective and more sensitive technique than the RTOG scale. Its use should be recommended to study cutaneous radioprotective action.

Hymes SR, Strom EA, Fife C (2006) Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J Am Acad Dermatol 54:28–46CrossRefPubMed

Ang KK, Wilder RB (2003) The skin. In: Cox JD, Ang KK (eds) Radiation oncology: rationale, technique, results, 8th edn. Mosby, St Louis, pp 127–143

Tucker S, Turesson I, Thames H (1992) Evidence of individual differences in the radiosensitivity of human skin. Eur J Cancer 28A:1782–1791

Porock D, Krisjanson L, Nikoletti S et al (1998) Predicting the severity of radiation skin reactions in women with breast cancer. Oncol Nurs Forum 25:1019–1029PubMed

Fernet M, Hall J (2004) Genetic biomarkers of therapeutic radiation sensitivity. DNA Repair (Amst) 3(8–9):1237–1243CrossRef

Spittle MT (1992) Radiotherapy and reactions to ionizing radiation. In: Champion RH, Burton JL, Ebling FJC (eds) Rook, Wilkinson, Ebling textbook of dermatology, 5th edn. Blackwell Scientific, Oxford, p 3089

Turesson I, Notter G (1975) Skin reactions after different fractionation schedules giving the same cumulative radiation effect. Acta Radiol Ther Phys Biol 14:475–484PubMed

Hansen O, Overgaard J, Hansen HS et al (1997) Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma; dependency on tumour differentiation. Radiother Oncol 43:47–51CrossRefPubMed

Bataini JP, Bernier J, Asselain B et al (1988) Primary radiotherapy of squamous cell carcinomas of the oropharynx and pharyngolarynx: tentative multivariate modelling system to predict the radiocurability of neck nodes. Int J Radiat Oncol Biol Phys 14:635–642CrossRefPubMed

10.

Campbell IR, Illingworth MH (1992) Can patients wash during radiotherapy to the breast or chest wall? A randomized controlled trial. Clin Oncol 4:78–82CrossRef

11.

Roy I, Fortin A, Larochelle M (2001) The impact of skin washing with water and soap during breast irradiation: a randomized study. Radiother Oncol 58:333–339CrossRefPubMed

12.

Lavery BA (1995) Skin care during radiotherapy: a survey of UK practice. Clin Oncol 7:184–187CrossRef

13.

Faithfull S (2001) Management of acute radiotherapy induced skin reactions: a literature review. Eur J Oncol Nurs 5(4):221–233CrossRef

14.

Halperin EC, Gaspar L, George S et al (1993) A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. Int J Radiat Oncol Biol Phys 26:413–416CrossRefPubMed

15.

Liguori V, Guillemin C, Pesce GF et al (1997) Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiother Oncol 42:155–161CrossRefPubMed

16.

Fenig E, Brenner B, Katz A et al (2001) Topical biafine and lipiderm for the prevention of radiation dermatitis: a randomized prospective trial. Oncol Rep 8:305–309PubMed

17.

Fisher J, Scott C, Stevens R et al (2000) Randomized phase III study comparing best supportive care to biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: radiation therapy oncology group (RTOG) 97–13. Int J Radiat Oncol Biol Phys 48:1307–1310CrossRefPubMed

18.

Boström A, Lindman H, Swartling C et al (2001) Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind randomized study. Radiother Oncol 59:257–265CrossRefPubMed

19.

Williams MS, Burk M, Loprinzi CL et al (1996) Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 36:345–349PubMed

20.

Heggie S, Bryant GP, Tripcony L et al (2002) Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs 25:442–451CrossRefPubMed

21.

Maiche A, Gröhn P, Mäki-Hokkonen H (1991) Effect of chamomile cream and almond ointment on acute radiation skin reaction. Acta Oncol 30:395–396CrossRefPubMed

22.

Løkkevik E, Skovlund E, Reitan JB et al (1996) Skin treatment with bepanthen cream versus no cream during radiotherapy—a randomized controlled trial. Acta Oncol 35(8):1021–1026CrossRefPubMed

23.

Maiche A, Isokangas O, Gröhn P (1994) Skin protection by sucralfate cream during electron beam therapy. Acta Oncol 33:201–203CrossRefPubMed

24.

Ochi K (1995) Chemistry of sucralfate. In: Hollander D, Tytgat GNJ (eds) Sucralfate from basic science to the bedside. Plenum medical, New York, pp 47–57

25.

Ishimori A (1995) History of the development of sucralfate. In: Hollander D, Tytgat GNJ (eds) Sucralfate from basic science to the bedside. Plenum medical, New York, pp 35–44

26.

Szabo S, Hollander D (1989) Pathways of gastrointestinal protection and repair: mechanisms of action of sucralfate. Am J Med 86:23–31CrossRefPubMed

27.

Romano M, Razandi M, Ivey K (1990) Effect of sucralfate and its components on taurocholate-induced damage to rat gastric mucosal cells in tissue culture. Dig Dis Sci 35:467–474CrossRefPubMed

28.

Konturek SJ, Brozozowski T, Bielanski W et al (1989) Epidermal growth factor in the gastroprotective and ulcer healing actions of sucralfate in rats. Am J Med 86:32–37CrossRefPubMed

29.

Henriksson R, Franzen L, Littbrand B (1987) Does sucralfate reduce radiation-induced diarrhea. Acta Oncol 26:76–77PubMed

30.

Henriksson R, Franzen L, Littbrand B (1992) Effects of sucralfate on acute and late bowel discomfort following radiotherapy of pelvic cancer. J Clin Oncol 10:969–975PubMed

31.

Henriksson R, Franzén L, Littbrand B (1991) Prevention of irradiation-induced bowel discomfort by sucralfate: a double-blind, placebo-controlled study when treating localized pelvic cancer. Am J Med 91(2A):151S–157SCrossRefPubMed

32.

Kochhar R, Sharma SC, Gupta BB et al (1988) Rectal sucralfate in radiation proctitis. Lancet 2(8607):400CrossRefPubMed

33.

Pfeiffer P, Madsen E, Hansen O et al (1990) Effect of prophylactic sucralfate suspension on stomatitis induced by cancer chemotherapy. A randomized, double-blind, cross-over study. Acta Oncol 29:171–173CrossRefPubMed

34.

Makkonen TA, Bostrom P, Vilja P et al (1994) Sucralfate mouth washing in the prevention of radiation-induced mucositis: a placebo-controlled double-blind study. Int J Radiat Oncol Biol Phys 30:177–182PubMed

35.

Meredith R, Salter M, Kim R et al (1997) Sucralfate for radiation mucositis: results of a double-blind randomized trial. Int J Radiat Oncol Biol Phys 37:275–279CrossRefPubMed

36.

Wells M, Macmillan M, Raab G et al (2004) Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial. Radiother Oncol 73(2):153–162CrossRefPubMed

37.

Priyadarsini KI, Maity DK, Naik GH et al (2003) Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radical Bio Med 35(5):475–484CrossRef

38.

Wang M, Jin Y, Ho CT (1999) Evaluation of resveratrol derivatives as potential antioxidants and identification of a reaction product of resveratrol and 2, 2-diphenyl-1-picryhydrazyl radical. J Agric Food Chem 47(10):3974–3977CrossRefPubMed

39.

Froment DH, Buddington B, Miller NL et al (1989) Effect of solubility on the gastrointestinal absorption of aluminum from various aluminum compounds in the rat. J Lab Clin Med 114:237–242PubMed

40.

Kozlowski D, Trouillas P, Calliste C et al (2007) Density functional theory study of the conformational, electronic, and antioxidant properties of natural chalcones. J Phys Chem A 111(6):1138–1145CrossRefPubMed

41.

Frisch MJ, Trucks GW, Schlegel HB et al (2004) Gaussian 03, Revision C.02. Gaussian, Wallingford

42.

Sitton E (1992) Early and late radiation-induced skin alterations Part I: mechanisms of skin changes. Oncol Nurs Forum 19:801–807PubMed

43.

Delanian S, Martin M, Housset M (1993) La fibrose iatrogénique en cancérologie (1ère partie): aspects descriptifs et physiopathologiques. Bull Cancer 80:192–201PubMed

44.

Delanian S (1995) Aspects physiopathologiques de la fibrose radio-induite. Bull Cancer/Radiother 82:88–93

45.

Fitzpatrick TB (1988) The validity and practicality of sun-reactive skin type I through VI, Arch. Dermatol 124:869–871

46.

Roberts WE (2009) Skin type classification systems old and new. Dermatol Clin 27:529–533CrossRefPubMed

Titel: Radiodermatitis prevention with sucralfate in breast cancer: fundamental and clinical studies
verfasst von: Sabrina Falkowski
Patrick Trouillas
Jean-Luc Duroux
Jean-Marie Bonnetblanc
Pierre Clavère
Publikationsdatum: 01.01.2011
Verlag: Springer-Verlag
Erschienen in: Supportive Care in Cancer / Ausgabe 1/2011
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-009-0788-y

Springer Medizin

Radiodermatitis prevention with sucralfate in breast cancer: fundamental and clinical studies

Abstract

Background

Methods

Results and conclusions

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Springer Medizin

Abstract

Background

Methods

Results and conclusions

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