nach oben

Supportive Care in Cancer

Erschienen in:

01.08.2011 | Original Article

Long-term quality of life after radical prostatectomy in wives of men in the postoperative adjuvant androgen deprivation trial

verfasst von: Katherine Regan Sterba, Richard J. Swartz, Karen Basen-Engquist, Peter C. Black, Curtis A. Pettaway

Erschienen in: Supportive Care in Cancer | Ausgabe 8/2011

Einloggen, um Zugang zu erhalten

Abstract

Purpose

We examined quality of life in spouses of men in the Post-Adjuvant Androgen Deprivation trial after radical prostatectomy.

Methods

Men at high risk of prostate cancer recurrence were randomized to receive androgen deprivation therapy or observation. Forty-three couples completed telephone interviews every 6 months for 2 years assessing women’s mood disturbance, mental and physical health, and sexual function and bother as well as men’s symptoms and sociodemographic and marital variables. We used linear mixed modeling to explore relationships between wives’ quality of life and time, treatment group, and men’s symptoms.

Results

Women’s mental health functioning improved over time (p < 0.05). Furthermore, women with husbands in the observation group had worse mood disturbance (p = 0.01) and poorer mental health (p = 0.02) than women with husbands in treatment. Men’s symptoms were associated with worse physical health in wives (p = 0.02). Women also reported worse sexual function at 18 and 24 months compared with baseline (p = 0.02), but ratings of sexual bother were unrelated to time, treatment, and symptoms.

Conclusions

These exploratory results are consistent with research demonstrating that spousal cancer-related distress decreases over time. Treatment group differences suggest that an examination of caregiving in the context of uncertainty is warranted. Also, the physical burden of caregiving may intensify when men have more symptoms. To inform interventions, future studies should clarify how treatment and symptoms influence wives’ distress by examining expectations and communication.

American Cancer Society (2009) Cancer facts & figures 2009. American Cancer Society, Atlanta

National Comprehensive Cancer Network (2009) National comprehensive cancer network practice guidelines in oncology: Prostate Cancer V.2.2009. http://www.nccn.org/professionals/physician_gls/PDF/prostate.pdf. Accessed June 18, 2009

Litwin MS, Hays RD, Fink A, Ganz PA, Leake B, Leach GE, Brook RH (1995) Quality-of-life outcomes in men treated for localized prostate cancer. JAMA 273:129–135PubMedCrossRef

Clark JA, Talcott JA (2006) Confidence and uncertainty long after initial treatment for early prostate cancer: survivors’ views of cancer control and the treatment decisions they made. J Clin Oncol 24(27):4457–4463PubMedCrossRef

Holzbeierlein JM, Castle E, Thrasher JB (2004) Complications of androgen deprivation therapy: prevention and treatment. Oncology 18:303–309PubMed

Black PC, Basen-Engquist K, Wang X, Swartz RJ, Eddings T, Matin SF, Swanson D, Wood CG, Pisters LL, Babaian RJ, Troncoso P, Pettaway CA (2007) A randomized prospective trial evaluating testosterone, haemoglobin kinetics and quality of life, during and after 12 months of androgen deprivation after prostatectomy: results from the postoperative adjuvant androgen deprivation trial. BJU Int 100:63–69PubMedCrossRef

Eton DT, Lepore SJ (2002) Prostate cancer and health-related quality of life: a review of the literature. Psychooncology 11(4):307–326PubMedCrossRef

Penson DF, Feng Z, Kuniyuki A, McClerran D, Albertsen PC, Deapen D, Gilliland F, Hoffman R, Stephenson RA, Potosky AL, Stanford JL (2007) General quality of life two years following treatment for prostate cancer: what influences outcomes? Results from the prostate cancer outcomes study. J Clin Oncol 21(6):1147–1154CrossRef

Couper J, Bloch S, Love A, MacVean M, Duchesne GM, Kissane D (2006) Psychological adjustment of female partners of men with prostate cancer: a review of the literature. Psychooncology 15:937–953PubMedCrossRef

10.

Thornton AA, Perez MA, Meyerowitz BE (2004) Patient and partner quality of life and psychosocial adjustment following radical prostatectomy. J Clin Psychol Med Settings 11(1):15–30CrossRef

11.

Northouse LL, Mood DW, Montie JE, Sandler HM, Forman JD, Hussain M, Pienta KJ, Smith DC, Sanda MG, Kershaw T (2007) Living with prostate cancer: patients’ and spouses’ psychosocial status and quality of life. J Clin Oncol 25(27):4171–4177PubMedCrossRef

12.

Kornblith AB, Herndon JE, Zuckerman E, Godley PA, Savarese D, Vogelzang NJ, Holland JC for the Cancer and Leukemia Group B (CALGB) (2001) The impact of docetaxel, estramustine, and low dose hydrocortisone on the quality of life of men with hormone refractory prostate cancer and their partners: a feasibility study. Ann Oncol 12:633–641CrossRef

13.

Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L, Lin X, Greenfield TK, Litwin MS, Saigal CS, Mahadevan A, Klein E, Kibel A, Pisters LL, Kuban D, Kaplan I, Wood D, Ciezki J, Shah N, Wei JT (2008) Quality of life and satisfaction with outcome among prostate cancer survivors. New Engl J Med 358:1250–1261PubMedCrossRef

14.

Cliff AM, MacDonagh RP (2000) Psychosocial morbidity in prostate cancer: II. A comparison of patients and partners. BJU Int 86:834–839PubMedCrossRef

15.

Han M, Partin AW, Pound CR, Epstein JI, Walsh PC (2001) Long term biochemical disease-free and cancer specific survival following anatomic radical retropubic prostatectomy. Urol Clin N Am 28:555–565CrossRef

16.

Lau WK, Bergstralh EJ, Blute ML, Slezak JM, Zincke H (2002) Radical prostatectomy for pathological gleason 8 or greater prostate cancer: influence of concomitant pathological variables. J Urol 167:117–122PubMedCrossRef

17.

Mian BM, Troncoso P, Okihara K, Bhadkamkar V, Johnston D, Reyes AO, Babaian RJ (2002) Outcome of patients with gleason score 8 or higher prostate cancer following radical prostatectomy alone. J Urol 167:1675–1680PubMedCrossRef

18.

McNair PM, Lorr M, Droppleman LF (1981) POMS manual, 2nd edn. Educational and Industrial Testing Service, San Diego

19.

Ware JE, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36®): I. Conceptual framework and item selection. Med Care 30(6):473–483PubMedCrossRef

20.

Ware JE, Kosinski M (2001) SF-36 physical and mental health summary scales: a manual for users of version 1, 2nd edn. Quality Metric Incorporated, Lincoln

21.

McHorney CA, Ware JE, Raczek AE (1993) The MOS 36-item short-form health survey (SF-36®): II. psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care 31(3):247–263PubMedCrossRef

22.

Litwin MS, Hays RD, Fink A, Ganz PA, Leake B, Brook RH (1998) The UCLA prostate cancer index: development, reliability, and validity of a health-related quality of life measure. Med Care 36:1002–1112PubMedCrossRef

23.

Moinpour CM, Savage MJ, Troxel A, Lovato LC, Eisenberger M, Veith RW, Higgins B, Skeel R, Yee M, Blumenstein BA, Crawford ED, Meyskens FL (1998) Quality of life in advanced prostate cancer: results of a randomized therapeutic trial. J Natl Cancer Inst 90(20):1537–1544PubMedCrossRef

24.

Spanier GB (1976) Measuring dyadic adjustment: new scales for assessing the quality of marriage and similar dyads. J Marriage Fam 38(1):15–28CrossRef

25.

Blackwell E, Mendes de Leon C, Miller GE (2006) Applying mixed regression models to the analysis of repeated-measures data in psychosomatic medicine. Psychsom Med 68:870–878CrossRef

26.

Diggle PJ, Heagerty P, Liang K-Y, Zeger SL (2002) Analysis of longitudinal data, 2nd edn. Oxford University Press, Oxford

27.

Cumming G (2009) Inference by eye: reading the overlap of independent confidence intervals. Stat Med 28:205–220PubMedCrossRef

28.

Krantz DH (1999) The null hypothesis testing controversy in psychology. J Am Stat Assoc 44:1372–1381CrossRef

29.

Schenker N, Gentleman JF (2001) On judging the significance of differences by examining the overlap between confidence intervals. Am Stat 55(3):182–186CrossRef

30.

Blouin DC, Riopelle AJ (2005) On confidence intervals for within-subjects designs. Psychol Methods 10(4):397–412PubMedCrossRef

31.

Gelman A, Stern H (2006) The difference between “significant” and “not significant” is not itself statistically significant. Am Stat 60(4):328–331CrossRef

32.

Hewitt ME, Greenfield S, Stovall E (eds) (2006) From cancer patient to cancer survivor: lost in translation. The National Academies Press, Washington

33.

Germino BB, Mishel MH, Belyea M, Harris L, Ware A, Mohler J (1998) Uncertainty in prostate cancer: ethnic and family patterns. Cancer Pract 6(2):107–113PubMedCrossRef

34.

Kornblith AB, Herr HW, Ofman US, Scher HI, Holland JC (1994) Quality of life of patients with prostate cancer and their spouses: the value of a database in clinical care. Cancer 73(13):2791–2802PubMedCrossRef

35.

Kurtz ME, Kurtz JC, Given CW, Given B (1995) Relationship of caregiver reactions and depression to cancer patients’ symptoms, functional status and depression—a longitudinal view. Soc Sci Med 40(6):837–846PubMedCrossRef

36.

Siegel K, Raveis VH, Mor V, Houts P (1991) The relationship of spousal caregiver burden to patient disease and treatment-related conditions. Ann Oncol 2:511–516PubMed

37.

Nijboer C, Tempelaar R, Sanderman R, Triemstra M, Spruijt RJ, Van den Bos G (1998) Cancer and caregiving: the impact on the caregiver’s health. Psychooncology 7:3–13PubMedCrossRef

38.

Perez MA, Skinner EC, Meyerowitz BE (2002) Sexuality and intimacy following radical prostatectomy: patient and partner perspectives. Health Psychol 21(3):281–293CrossRef

39.

Soloway CT, Soloway MS, Kim SS, Kava BR (2005) Sexual, psychological and dyadic qualities of the prostate cancer ‘couple’. BJU Int 95:780–785PubMedCrossRef

40.

Bodenmann G (1997) Dyadic coping—a systemic-transactional conceptualization of stress and coping among couples: theory and empirical findings. Eur Rev Appl Psychol 47:137–140

41.

Burish TG, Snyder SL, Jenkins RA (1991) Preparing patients for cancer chemotherapy: effect of coping preparation and relaxation interventions. J Consult Clin Psychol 59:518–525PubMedCrossRef

42.

Merluzzi TV, Martinez Sanchez MA (1997) Assessment of self-efficacy and coping with cancer: development and validation of the cancer behavior inventory. Health Psychol 16(2):163–170PubMedCrossRef

43.

Badr H, Taylor CL (2009) Sexual dysfunction and spousal communication in couples coping with prostate cancer. Psychooncology 18(7):735–746PubMedCrossRef

44.

Manne S, Badr H, Zaider T, Nelson C, Kissane D (2010) Cancer-related communication, relationship intimacy and psychological distress among couples coping with localized prostate cancer. J Cancer Surviv 4(1):74–85PubMedCrossRef

Titel: Long-term quality of life after radical prostatectomy in wives of men in the postoperative adjuvant androgen deprivation trial
verfasst von: Katherine Regan Sterba
Richard J. Swartz
Karen Basen-Engquist
Peter C. Black
Curtis A. Pettaway
Publikationsdatum: 01.08.2011
Verlag: Springer-Verlag
Erschienen in: Supportive Care in Cancer / Ausgabe 8/2011
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-010-0916-8

Springer Medizin

Long-term quality of life after radical prostatectomy in wives of men in the postoperative adjuvant androgen deprivation trial