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01.03.2013 | Original Article

Implementation of modified early-goal directed therapy for sepsis in the emergency center of a comprehensive cancer center

verfasst von: Katy M. Hanzelka, Sai-Ching J. Yeung, Gary Chisholm, Kelly Willis Merriman, Susan Gaeta, Imrana Malik, Terry W. Rice

Erschienen in: Supportive Care in Cancer | Ausgabe 3/2013

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Abstract

Purpose

The investigation examines the impact of a standardized sepsis order set and algorithm utilizing non-invasive monitoring for early-goal directed therapy (EGDT) in an emergency center setting on the clinical outcomes of sepsis in cancer patients.

Methods

Single-center, retrospective study comparing clinical outcomes of sepsis before and after routine usage of a standardized order set and algorithm for non-invasive elements of EGDT for sepsis in an emergency center of a comprehensive cancer center. The outcomes measures evaluated were 28-day in-hospital mortality, intensive care unit length of stay, hospital length of stay, goal mean arterial pressure and urine output within the first 6 h of treatment, time to measurement of lactic acid, and appropriateness and timeliness of initial antibiotic therapy.

Results

The 28-day in-hospital mortality was significantly lower in the post-intervention group compared to the pre-intervention group (20 vs. 38 %, p = 0.005). The percentages of patients who reached their goal mean arterial pressure (74 vs. 90 %, p = 0.004) and goal urine output (79 vs. 96 %, p = 0.002) during the first 6 h of treatment were higher the after than the before group. No significant differences were detected in the rest of the outcome measures.

Conclusions

Implementation of a standardized sepsis order set and algorithm to improve compliance with the non-invasive elements of EGDT for sepsis in cancer patients in the emergency center setting was associated with a decreased 28-day in-hospital mortality rate.

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Titel: Implementation of modified early-goal directed therapy for sepsis in the emergency center of a comprehensive cancer center
verfasst von: Katy M. Hanzelka
Sai-Ching J. Yeung
Gary Chisholm
Kelly Willis Merriman
Susan Gaeta
Imrana Malik
Terry W. Rice
Publikationsdatum: 01.03.2013
Verlag: Springer-Verlag
Erschienen in: Supportive Care in Cancer / Ausgabe 3/2013
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-012-1572-y

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25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Implementation of modified early-goal directed therapy for sepsis in the emergency center of a comprehensive cancer center

Abstract

Purpose

Methods

Results

Conclusions

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Results

Conclusions

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