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Supportive Care in Cancer
Erschienen in: Supportive Care in Cancer 1/2014

01.01.2014 | Review Article

Cognitive impairment in gynecologic cancers: a systematic review of current approaches to diagnosis and treatment

verfasst von: Christine D. Craig, Bradley J. Monk, John H. Farley, Dana M. Chase

Erschienen in: Supportive Care in Cancer | Ausgabe 1/2014

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Abstract

Purpose

To review the etiology and assessment of chemotherapy-related cognitive impairment (CRCI). To explore current treatment and prevention strategies for CRCI and propose future research goals in the field of gynecologic oncology.

Methods

Computerized searches in PubMed of cognitive impairment in cancer between 2000 and 2012 were conducted. The inclusion criteria were randomized control trials evaluating treatment of CRCI and search terms 'cognitive function, cognitive impairment, cognitive decline, chemobrain, chemofog, and cancer'.

Results

To date, numerous modalities have been utilized for assessing CRCI in patients undergoing therapy. It has been proposed to move towards web-based assessment modalities as a possible standard. Few studies have aimed to elucidate possible treatment and prevention options for CRCI; even less in the field of gynecologic oncology. Only seven of these studies were subjected to randomized control trials. Only one of these studies looked at treatment in patients with gynecologic cancers.

Conclusions

The etiology of CRCI is multi-factorial. Following from this, there is no consensus on the best way to assess CRCI although objective measures are more reliable. One must extrapolate data from the non-gynecologic cancer literature, even venturing to non-cancer literature, to explore the treatment and prevention of CRCI. The methods found in these areas of research have not yet been applied to CRCI in gynecologic oncology.
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Metadaten
Titel
Cognitive impairment in gynecologic cancers: a systematic review of current approaches to diagnosis and treatment
verfasst von
Christine D. Craig
Bradley J. Monk
John H. Farley
Dana M. Chase
Publikationsdatum
01.01.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 1/2014
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-013-2029-7

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