Aneurysmal bone cysts of the spine

The prevalence of ABCs is 1.4 cases per 100,000 individuals, and they constitute approximately 1 % of all bone tumors [2, 7]. The lesions primarily occur in the first two decades of life, with slight women predominance [10]. In this study, mean age was 22.1 years similar with the literature but we have a male predominance (61 %).

ABCs are benign, highly vascular, locally aggressive tumors and recurrence rates after curettage were reported equal or less than 50 % [1, 3]. Spontaneous regression of the tumor is uncommon [11]. Malghem [12] has reported spontaneous healing in three patients.

ABCs have a predilection for the lumbar spine in the series of Boriani and De Kleuver [7, 13]. In contrast, in Papagelopoulos’ and Vergel de Dios’ series, cervical and thoracic spine were involved more than lumbar spine [3, 5]. In our series, sacrum and lumbar spine were involved more than others.

The combination of radiographs, CT scans, and MRI is diagnostic in many cases. Characteristic ballooning of the posterior elements with a thin rim may be shown on plain radiographs [14]. CT imaging reveals multiloculated lytic lesions with multiple internal septations, pathologic fracture or vertebral body collapse. CT scans are also useful for planning of possible instrumentation landmarks during surgery [15]. On MR imaging, ABCs usually demonstrate a thin, well defined rim of low signal intensity in the periphery and they are seen as multiseptate lesions. Usually each lobule represents different signal characteristics giving the tumor a heterogenous appearance. Both CT and MRI are important diagnostic tools for planning the surgical management [7]. We performed both CT and MR for the diagnosis.

Fluid–fluid levels can be seen in the ABC, but this finding is not specific for ABCs. This appearance is also seen in the other bone lesions, which contain areas of hemorrhage or necrosis such as telangiectatic osteosarcoma, giant cell tumor, and chondroblastoma [16]. Differential diagnosis of ABCs includes giant cell tumor, chondroblastoma, chondromyxoid fibroma, fibrosarcoma, telangiectatic osteosarcoma, fibrous dysplasia, simple bone cyst, osteoblastoma, and plasmocytoma [4, 17]. Keenan et al. [18] reported that in their series of patients the incidence of fluid–fluid levels was 85 %. However, in our study fluid–fluid levels were present only in 10 of 18 cases (55 %). This may be because we only evaluated spinal ABCs whereas Keenan et al. have included ABCs originating from the whole skeleton. The question whether spinal ABCs show less frequent fluid–fluid levels than the other parts of the skeleton should be answered through further imaging studies. Another point was to determine whether the nature of ABCs (having fluid–fluid levels versus solid) have influenced the results of the surgical treatment. However, there was no significant difference of the recurrence rates of cystic or solid type of aneurysmal bone cysts.

Although CT an MR are diagnostic methods for many cases, it is noted that in the literature, biopsy is necessary for confirmation, since many bone lesions can have a similar appearance [19]. However, it must be performed cautiously for sometimes needle biopsies can cause complications because the material obtained may consist of mostly blood elements. To prevent such complications, open biopsy and frozen sections were recommended to establish the diagnosis [20]. In this study, biopsy was performed in six cases and we did not see any complication.

Histological examination is definitely necessary to confirm the differential diagnosis. The histology of ABC is typically characterized by cavernous channels surrounded by a spindle cell stroma with osteoclast like giant cells and osteoid production [21]. There are some hypotheses in the literature that the tumor is the result of either hemorrhage into the tumor, or a vascular disturbance of the bone, or improper repair of a traumatic subperiosteal hemorrhages [22].

Treatment of ABC is also controversial. The options for treatment are curettage with or without bone grafting, complete excision, arterial embolization, intralesional drug injections (steroid and calcitonin), and radiation [6, 8]. Early diagnosis and appropriate surgical treatment of ABCs in the spine remain the key factors to successful management [23]. Total excision with or without instrumentation is the optimal approach for local control of tumor and it prevents recurrence [19]. We performed 13 total and 5 subtotal excision with 5 recurrences in this series.

PMMA injection (vertebroplasty or kyphoplasty) may be used to reinforce the bony defects after curettage [24]. Three patients in this study were also reinforced by PMMA injections after removal. There are also reports that the injections of calcitonin or methyl prednisolone inside the ABC cavities are safe procedures with no side effects [14]. Radiotherapy was recommended in inoperable cases, but it has numerous and severe complications including osteonecrosis, gonodal damage, myelopathy and induction of osteosarcoma [3, 6]. Also, preoperative embolization may be performed to minimize intraoperative blood loss [19, 25]. In 2010, Rossi et al. [26] reported their experiences and they considered selective arterial embolization is a less invasive, more feasible, effective and repeatable alternative method to standard surgical treatments. However, we did not use that method in any case in this series.

Recurrence is reported in 10–44 % of the cases, and usually rare when the tumor is excised completely [3]. Ninty percent of recurrences occur within 2 years. Thus, post-treatment follow-up should be at least 24 months [1, 3, 7]. In this series, 13 of 18 patients had a radical surgical removal. We detected four recurrences in subtotal excision group (4/5), and one recurrence in total excision group (1/13). Hay et al. [4] reported that there were no recurrences when total excision was performed, and a 25 % recurrence rate after partial excision. Total excision of large tumors results in bony instability, and instrumentation is necessary to maintain structural integrity [27]. It is also reported that careful preoperative planning is important for management of post excision spinal instability [19]. In this series, six patients have undergone spinal stabilization to prevent spinal deformity and instability.