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Surgery Today
Erschienen in: Surgery Today 4/2013

01.04.2013 | Original Article

Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy

verfasst von: Yohei Nagai, Masayuki Watanabe, Yoshihumi Baba, Masaaki Iwatsuki, Kotaro Hirashima, Ryuichi Karashima, Jyunji Kurashige, Koichi Kinoshita, Hideo Baba

Erschienen in: Surgery Today | Ausgabe 4/2013

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Abstract

Purpose

Sivelestat, a selective inhibitor of neutrophil elastase, has been reported to reduce acute lung injury associated with systemic inflammatory response syndrome. This study retrospectively investigated the effect of sivelestat on respiratory function in patients who underwent esophagectomy.

Methods

Patients who underwent esophagectomy for thoracic esophageal cancer between 2005 and 2010 were included in this study. Forty-two were treated perioperatively with sivelestat (4.8 mg/kg/day; sivelestat group) and the remaining 35 were not (control group). Sivelestat was administered continuously from the beginning of surgery until postoperative day 3. All patients were administered methylprednisolone for 3 days. The perioperative clinical and laboratory data, total sequential organ failure assessment score, PaO2/FiO2 ratio (P/F ratio) and postoperative complications were compared between the two groups.

Results

There were no significant differences between the groups in the patients’ background data. The P/F ratio immediately after surgery was significantly higher in the sivelestat group than in the control group (p < 0.05). The respiratory rate immediately after surgery and the temperature on postoperative day 2 were significantly lower in the sivelestat group than in the control group (p < 0.05). There were no differences in any of the other clinical data or complications.

Conclusions

Perioperative administration of sivelestat improves postoperative respiratory function in patients after esophagectomy.
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Metadaten
Titel
Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy
verfasst von
Yohei Nagai
Masayuki Watanabe
Yoshihumi Baba
Masaaki Iwatsuki
Kotaro Hirashima
Ryuichi Karashima
Jyunji Kurashige
Koichi Kinoshita
Hideo Baba
Publikationsdatum
01.04.2013
Verlag
Springer Japan
Erschienen in
Surgery Today / Ausgabe 4/2013
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-013-0508-6

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