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01.04.2014 | Original Article

Efficacy of a high FFP:PRBC transfusion ratio on the survival of severely injured patients: a retrospective study in a single tertiary emergency center in Japan

verfasst von: Daisuke Kudo, Junichi Sasaki, Satoshi Akaishi, Satoshi Yamanouchi, Tomoaki Koakutsu, Tomoyuki Endo, Takeaki Sato, Ryosuke Nomura, Hironao Yuzawa, Michio Kobayashi, Yotaro Shinozawa, Shigeki Kushimoto

Erschienen in: Surgery Today | Ausgabe 4/2014

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Abstract

Purpose

Recent studies have shown increased survival benefits when a high fresh frozen plasma (FFP) to packed red blood cell (PRBC) ratio is used during trauma resuscitation. However, some reports have raised questions about the effect of higher FFP:PRBC transfusion ratios. The aim of this study was to examine the efficacy of high FFP:PRBC ratios in injured patients with regard to survival and morbidity in a single tertiary emergency center in Japan.

Methods

This study examined severe trauma patients who received 10 or more PRBC units during the first 24 h of admission. We examined the relationship between the FFP:PRBC ratios during the first 6 h and the patient outcome.

Results

The severity was similar among all groups. The mortality rate was 44.4 % in the high (>1:1.5), 16.7 % in the middle (1:1.5–1:2) and 33.3 % in the low (<1:2) F:P ratio groups. Only one patient in the high group developed sepsis, and none of the patients developed ARDS.

Conclusions

The current results indicate that the FFP:PRBC ratios during the first 6 h after admission might not affect the mortality or morbidity. However, differences between trauma care systems in Japan and other countries, along with other study limitations, necessitate that a subsequent prospective multicenter study be undertaken before any definitive conclusions can be made.

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Titel: Efficacy of a high FFP:PRBC transfusion ratio on the survival of severely injured patients: a retrospective study in a single tertiary emergency center in Japan
verfasst von: Daisuke Kudo
Junichi Sasaki
Satoshi Akaishi
Satoshi Yamanouchi
Tomoaki Koakutsu
Tomoyuki Endo
Takeaki Sato
Ryosuke Nomura
Hironao Yuzawa
Michio Kobayashi
Yotaro Shinozawa
Shigeki Kushimoto
Publikationsdatum: 01.04.2014
Verlag: Springer Japan
Erschienen in: Surgery Today / Ausgabe 4/2014
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-013-0518-4

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Efficacy of a high FFP:PRBC transfusion ratio on the survival of severely injured patients: a retrospective study in a single tertiary emergency center in Japan

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Purpose

Methods

Results

Conclusions

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