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Erschienen in: Surgery Today 11/2014

01.11.2014 | Original Article

Prospective clinical audit of two neuromodulatory treatments for fecal incontinence: sacral nerve stimulation (SNS) and percutaneous tibial nerve stimulation (PTNS)

verfasst von: Alexander Hotouras, Jamie Murphy, Marion Allison, Anne Curry, Norman S. Williams, Charles H. Knowles, Christopher L. Chan

Erschienen in: Surgery Today | Ausgabe 11/2014

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Abstract

Background and purpose

Two types of neuromodulation are currently practised for the treatment of fecal incontinence (FI): sacral nerve stimulation (SNS) and percutaneous tibial nerve stimulation (PTNS). This study compares these therapies, as no data exist to prospectively assess their relative efficacy and costs.

Methods

The subjects of this study were two distinct cohorts undergoing SNS (between 2003 and 2008) or PTNS (2008-onwards) for FI. Clinical outcomes assessed at 3 months included incontinence scores and the number of weekly incontinence episodes. The direct medical costs for each procedure were calculated from the audited expenditure of our unit.

Results

Thirty-seven patients (94.6 % women) underwent permanent SNS and 146 (87.7 % women) underwent PTNS. The mean pre-treatment incontinence score (±SD) was greater in the SNS cohort (14 ± 4 vs. 12 ± 4) and the mean post-treatment incontinence scores were similar for the two therapies (9 ± 5 vs. 10 ± 4), with a greater effect size evident in the SNS patients. In a ‘pseudo case–control’ analysis with 37 “matched” patients, the effect of both treatments was similar. The cost of treating a patient for 1 year was £11 374 ($18 223) for permanent SNS vs. £1740 ($2784) for PTNS.

Conclusion

Given the lesser cost and invasive nature of PTNS, where both techniques are available, a trial of PTNS could be considered for all patients.
Literatur
1.
Zurück zum Zitat Sung VW, Rogers ML, Myers DL, Akbari HM, Clark MA. National trends and costs of surgical treatment for female fecal incontinence. Am J Obstet Gynecol. 2007;197(652):e1–5. Sung VW, Rogers ML, Myers DL, Akbari HM, Clark MA. National trends and costs of surgical treatment for female fecal incontinence. Am J Obstet Gynecol. 2007;197(652):e1–5.
2.
Zurück zum Zitat Hotouras A, Allison M, Currie A, Knowles CH, Chan CL, Thaha MA. Percutaneous tibial nerve stimulation for fecal incontinence: a video demonstration. Dis Colon Rectum. 2012;55:711–3.PubMedCrossRef Hotouras A, Allison M, Currie A, Knowles CH, Chan CL, Thaha MA. Percutaneous tibial nerve stimulation for fecal incontinence: a video demonstration. Dis Colon Rectum. 2012;55:711–3.PubMedCrossRef
3.
Zurück zum Zitat Navarro JM, Arroyo Sebastian A, Perez Vicente F, Sanchez Romero AM, Perez Legaz J, et al. Sacral root neuromodulation as treatment for fecal incontinence. Preliminary results. Revista espanola de enfermedades. 2007;99:636–42. Navarro JM, Arroyo Sebastian A, Perez Vicente F, Sanchez Romero AM, Perez Legaz J, et al. Sacral root neuromodulation as treatment for fecal incontinence. Preliminary results. Revista espanola de enfermedades. 2007;99:636–42.
4.
Zurück zum Zitat Matzel KE, Kamm MA, Stosser M, Baeten CG, Christiansen J, et al. Sacral spinal nerve stimulation for faecal incontinence: multicentre study. Lancet. 2004;363:1270–6.PubMedCrossRef Matzel KE, Kamm MA, Stosser M, Baeten CG, Christiansen J, et al. Sacral spinal nerve stimulation for faecal incontinence: multicentre study. Lancet. 2004;363:1270–6.PubMedCrossRef
5.
Zurück zum Zitat Brown SR, Wadhawan H, Nelson RL. Surgery for faecal incontinence in adults. Cochrane Database Syst Rev. 2010;9:CD001757.PubMed Brown SR, Wadhawan H, Nelson RL. Surgery for faecal incontinence in adults. Cochrane Database Syst Rev. 2010;9:CD001757.PubMed
6.
Zurück zum Zitat Melenhorst J, Koch SM, Uludag O, van Gemert WG, Baeten CG. Is a morphologically intact anal sphincter necessary for success with sacral nerve modulation in patients with faecal incontinence? Colorectal Dis. 2008;10(3):257–62.PubMedCrossRef Melenhorst J, Koch SM, Uludag O, van Gemert WG, Baeten CG. Is a morphologically intact anal sphincter necessary for success with sacral nerve modulation in patients with faecal incontinence? Colorectal Dis. 2008;10(3):257–62.PubMedCrossRef
7.
Zurück zum Zitat Griffin KM, Pickering M, O’Herlihy C, O’Connell PR, Jones JF. Sacral nerve stimulation increases activation of the primary somatosensory cortex by anal canal stimulation in an experimental model. Br J Surg. 2011;98:1160–9.PubMedCrossRef Griffin KM, Pickering M, O’Herlihy C, O’Connell PR, Jones JF. Sacral nerve stimulation increases activation of the primary somatosensory cortex by anal canal stimulation in an experimental model. Br J Surg. 2011;98:1160–9.PubMedCrossRef
8.
Zurück zum Zitat Allison M. Percutaneous tibial nerve stimulation for patients with faecal incontinence. Nurs Stand. 2011;25:44–8.PubMedCrossRef Allison M. Percutaneous tibial nerve stimulation for patients with faecal incontinence. Nurs Stand. 2011;25:44–8.PubMedCrossRef
9.
Zurück zum Zitat Malouf AJ, Vaizey CJ, Norton CS, Kamm MA. Internal anal sphincter augmentation for fecal incontinence using injectable silicone biomaterial. Dis Colon Rectum. 2001;44:595–600.PubMedCrossRef Malouf AJ, Vaizey CJ, Norton CS, Kamm MA. Internal anal sphincter augmentation for fecal incontinence using injectable silicone biomaterial. Dis Colon Rectum. 2001;44:595–600.PubMedCrossRef
10.
Zurück zum Zitat Wong WD, Congliosi SM, Spencer MP, Corman ML, Tan P, et al. The safety and efficacy of the artificial bowel sphincter for fecal incontinence: results from a multicenter cohort study. Dis Colon Rectum. 2002;45:1139–53.PubMedCrossRef Wong WD, Congliosi SM, Spencer MP, Corman ML, Tan P, et al. The safety and efficacy of the artificial bowel sphincter for fecal incontinence: results from a multicenter cohort study. Dis Colon Rectum. 2002;45:1139–53.PubMedCrossRef
11.
Zurück zum Zitat Tillin T, Gannon K, Feldman RA, Williams NS. Third-party prospective evaluation of patient outcomes after dynamic graciloplasty. Br J Surg. 2006;93:1402–10.PubMedCrossRef Tillin T, Gannon K, Feldman RA, Williams NS. Third-party prospective evaluation of patient outcomes after dynamic graciloplasty. Br J Surg. 2006;93:1402–10.PubMedCrossRef
12.
Zurück zum Zitat Dudding TC, Pares D, Vaizey CJ, Kamm MA. Predictive factors for successful sacral nerve stimulation in the treatment of faecal incontinence: a 10-year cohort analysis. Colorectal Dis. 2008;10:249–56.PubMedCrossRef Dudding TC, Pares D, Vaizey CJ, Kamm MA. Predictive factors for successful sacral nerve stimulation in the treatment of faecal incontinence: a 10-year cohort analysis. Colorectal Dis. 2008;10:249–56.PubMedCrossRef
13.
Zurück zum Zitat Boyle DJ, Murphy J, Gooneratne ML, Grimmer K, Allison ME, et al. Efficacy of sacral nerve stimulation for the treatment of fecal incontinence. Dis Colon Rectum. 2011;54:1271–8.PubMedCrossRef Boyle DJ, Murphy J, Gooneratne ML, Grimmer K, Allison ME, et al. Efficacy of sacral nerve stimulation for the treatment of fecal incontinence. Dis Colon Rectum. 2011;54:1271–8.PubMedCrossRef
14.
Zurück zum Zitat Matzel KE, Stadelmaier U, Hohenfellner M, Gall FP. Electrical stimulation of sacral spinal nerves for treatment of faecal incontinence. Lancet. 1995;346:1124–7.PubMedCrossRef Matzel KE, Stadelmaier U, Hohenfellner M, Gall FP. Electrical stimulation of sacral spinal nerves for treatment of faecal incontinence. Lancet. 1995;346:1124–7.PubMedCrossRef
15.
Zurück zum Zitat Hetzer FH, Bieler A, Hahnloser D, Lohlein F, Clavien PA, Demartines N. Outcome and cost analysis of sacral nerve stimulation for faecal incontinence. Br J Surg. 2006;93:1411–7.PubMedCrossRef Hetzer FH, Bieler A, Hahnloser D, Lohlein F, Clavien PA, Demartines N. Outcome and cost analysis of sacral nerve stimulation for faecal incontinence. Br J Surg. 2006;93:1411–7.PubMedCrossRef
16.
Zurück zum Zitat Dudding TC, Meng Lee E, Faiz O, Pares D, Vaizey CJ, et al. Economic evaluation of sacral nerve stimulation for faecal incontinence. Br J Surg. 2008;95:1155–63. Dudding TC, Meng Lee E, Faiz O, Pares D, Vaizey CJ, et al. Economic evaluation of sacral nerve stimulation for faecal incontinence. Br J Surg. 2008;95:1155–63.
17.
Zurück zum Zitat George AT, Kalmar K, Panarese A, Dudding TC, Nicholls RJ, Vaizey CJ. Long-term outcomes of sacral nerve stimulation for fecal incontinence. Dis Colon Rectum. 2012;55:302–6.PubMedCrossRef George AT, Kalmar K, Panarese A, Dudding TC, Nicholls RJ, Vaizey CJ. Long-term outcomes of sacral nerve stimulation for fecal incontinence. Dis Colon Rectum. 2012;55:302–6.PubMedCrossRef
18.
Zurück zum Zitat Matzel KE. Sacral nerve stimulation for faecal incontinence: its role in the treatment algorithm. Colorectal Dis. 2011;13(Suppl 2):10–4.PubMedCrossRef Matzel KE. Sacral nerve stimulation for faecal incontinence: its role in the treatment algorithm. Colorectal Dis. 2011;13(Suppl 2):10–4.PubMedCrossRef
19.
Zurück zum Zitat Tjandra JJ, Lim JF, Matzel K. Sacral nerve stimulation: an emerging treatment for faecal incontinence. ANZ J Surg. 2004;74:1098–106.PubMedCrossRef Tjandra JJ, Lim JF, Matzel K. Sacral nerve stimulation: an emerging treatment for faecal incontinence. ANZ J Surg. 2004;74:1098–106.PubMedCrossRef
20.
Zurück zum Zitat Shafik A, Ahmed I, El-Sibai O, Mostafa RM. Percutaneous peripheral neuromodulation in the treatment of fecal incontinence. Eur Surg Res. 2003;35:103–7.PubMedCrossRef Shafik A, Ahmed I, El-Sibai O, Mostafa RM. Percutaneous peripheral neuromodulation in the treatment of fecal incontinence. Eur Surg Res. 2003;35:103–7.PubMedCrossRef
21.
Zurück zum Zitat Mentes BB, Yuksel O, Aydin A, Tezcaner T, Leventoglu A, Aytac B. Posterior tibial nerve stimulation for faecal incontinence after partial spinal injury: preliminary report. Tech Coloproctol. 2007;11:115–9.PubMedCrossRef Mentes BB, Yuksel O, Aydin A, Tezcaner T, Leventoglu A, Aytac B. Posterior tibial nerve stimulation for faecal incontinence after partial spinal injury: preliminary report. Tech Coloproctol. 2007;11:115–9.PubMedCrossRef
22.
Zurück zum Zitat Boyle DJ, Prosser K, Allison ME, Williams NS, Chan CL. Percutaneous tibial nerve stimulation for the treatment of urge fecal incontinence. Dis Colon Rectum. 2010;53:432–7.PubMedCrossRef Boyle DJ, Prosser K, Allison ME, Williams NS, Chan CL. Percutaneous tibial nerve stimulation for the treatment of urge fecal incontinence. Dis Colon Rectum. 2010;53:432–7.PubMedCrossRef
23.
Zurück zum Zitat Findlay JM, Yeung JM, Robinson R, Greaves H, Maxwell-Armstrong C. Peripheral neuromodulation via posterior tibial nerve stimulation - a potential treatment for faecal incontinence? Ann R Coll Surg Eng. 2010;92:385–90.CrossRef Findlay JM, Yeung JM, Robinson R, Greaves H, Maxwell-Armstrong C. Peripheral neuromodulation via posterior tibial nerve stimulation - a potential treatment for faecal incontinence? Ann R Coll Surg Eng. 2010;92:385–90.CrossRef
24.
Zurück zum Zitat Govaert B, Pares D, Delgado-Aros S, La Torre F, Van Gemert WG, Baeten CG. A prospective multicentre study to investigate percutaneous tibial nerve stimulation for the treatment of faecal incontinence. Colorectal Dis. 2010;12:1236–41.PubMedCrossRef Govaert B, Pares D, Delgado-Aros S, La Torre F, Van Gemert WG, Baeten CG. A prospective multicentre study to investigate percutaneous tibial nerve stimulation for the treatment of faecal incontinence. Colorectal Dis. 2010;12:1236–41.PubMedCrossRef
25.
Zurück zum Zitat Hotouras A, Thaha MA, Boyle D, Allison ME, Currie A, et al. Short-term outcome following percutaneous tibial nerve stimulation (PTNS) for faecal incontinence: a single-centre prospective study. Colorectal Dis. 2012;14:1101–5.PubMedCrossRef Hotouras A, Thaha MA, Boyle D, Allison ME, Currie A, et al. Short-term outcome following percutaneous tibial nerve stimulation (PTNS) for faecal incontinence: a single-centre prospective study. Colorectal Dis. 2012;14:1101–5.PubMedCrossRef
26.
Zurück zum Zitat de la Portilla F, Rada R, Vega J, Gonzalez CA, Cisneros N, Maldonado VH. Evaluation of the use of posterior tibial nerve stimulation for the treatment of fecal incontinence: preliminary results of a prospective study. Dis Colon Rectum. 2009;52:1427–33.PubMedCrossRef de la Portilla F, Rada R, Vega J, Gonzalez CA, Cisneros N, Maldonado VH. Evaluation of the use of posterior tibial nerve stimulation for the treatment of fecal incontinence: preliminary results of a prospective study. Dis Colon Rectum. 2009;52:1427–33.PubMedCrossRef
27.
Zurück zum Zitat Jorge JM, Wexner SD. Etiology and management of fecal incontinence. Dis Colon Rectum. 1993;36:77–97.PubMedCrossRef Jorge JM, Wexner SD. Etiology and management of fecal incontinence. Dis Colon Rectum. 1993;36:77–97.PubMedCrossRef
28.
Zurück zum Zitat Medtronic. Patient diary, version 1.0. Minneapolis. 2001. Medtronic. Patient diary, version 1.0. Minneapolis. 2001.
29.
Zurück zum Zitat Otto SD, Burmeister S, Buhr HJ, Kroesen A. Sacral nerve stimulation induces changes in the pelvic floor and rectum that improve continence and quality of life. J Gastrointest Surg. 2010;14:636–44.PubMedCrossRef Otto SD, Burmeister S, Buhr HJ, Kroesen A. Sacral nerve stimulation induces changes in the pelvic floor and rectum that improve continence and quality of life. J Gastrointest Surg. 2010;14:636–44.PubMedCrossRef
30.
Zurück zum Zitat Hetzer FH, Hahnloser D, Clavien PA, Demartines N. Quality of life and morbidity after permanent sacral nerve stimulation for fecal incontinence. Arch Surg. 2007;142:8–13.PubMedCrossRef Hetzer FH, Hahnloser D, Clavien PA, Demartines N. Quality of life and morbidity after permanent sacral nerve stimulation for fecal incontinence. Arch Surg. 2007;142:8–13.PubMedCrossRef
31.
Zurück zum Zitat Michelsen HB, Buntzen S, Krogh K, Laurberg S. Rectal volume tolerability and anal pressures in patients with fecal incontinence treated with sacral nerve stimulation. Dis Colon Rectum. 2006;49:1039–44.PubMedCrossRef Michelsen HB, Buntzen S, Krogh K, Laurberg S. Rectal volume tolerability and anal pressures in patients with fecal incontinence treated with sacral nerve stimulation. Dis Colon Rectum. 2006;49:1039–44.PubMedCrossRef
32.
Zurück zum Zitat Leroi AM, Parc Y, Lehur PA, Mion F, Barth X, Rullier E, et al. Efficacy of sacral nerve stimulation for fecal incontinence: results of a multicenter double-blind crossover study. Ann Surg. 2005;242:662–9.PubMedCrossRefPubMedCentral Leroi AM, Parc Y, Lehur PA, Mion F, Barth X, Rullier E, et al. Efficacy of sacral nerve stimulation for fecal incontinence: results of a multicenter double-blind crossover study. Ann Surg. 2005;242:662–9.PubMedCrossRefPubMedCentral
33.
Zurück zum Zitat Rasmussen OO, Buntzen S, Sorensen M, Laurberg S, Christiansen J. Sacral nerve stimulation in fecal incontinence. Dis Colon Rectum. 2004;47:1158–62 (discussion 62–3).PubMedCrossRef Rasmussen OO, Buntzen S, Sorensen M, Laurberg S, Christiansen J. Sacral nerve stimulation in fecal incontinence. Dis Colon Rectum. 2004;47:1158–62 (discussion 62–3).PubMedCrossRef
34.
Zurück zum Zitat Soria-Aledo V, Mengual-Ballester M, Pellicer-Franco E, Aguayo-Albasini JL. Improvement in the quality of life of faecal incontinent patients after sacral root stimulation treatment]. Cirugia espanola. 2011;89:581–7.PubMedCrossRef Soria-Aledo V, Mengual-Ballester M, Pellicer-Franco E, Aguayo-Albasini JL. Improvement in the quality of life of faecal incontinent patients after sacral root stimulation treatment]. Cirugia espanola. 2011;89:581–7.PubMedCrossRef
35.
Zurück zum Zitat Uludag O, Koch SM, Vliegen RF, Dejong CH, van Gemert WG, Baeten CG. Sacral neuromodulation: does it affect the rectoanal angle in patients with fecal incontinence? World J Surg. 2010;34:1109–14.PubMedCrossRef Uludag O, Koch SM, Vliegen RF, Dejong CH, van Gemert WG, Baeten CG. Sacral neuromodulation: does it affect the rectoanal angle in patients with fecal incontinence? World J Surg. 2010;34:1109–14.PubMedCrossRef
36.
Zurück zum Zitat Hotouras A, Thaha MA, Allison ME, Currie A, Scott SM, Chan CL. Percutaneous tibial nerve stimulation (PTNS) in females with faecal incontinence: the impact of sphincter morphology and rectal sensation on the clinical outcome. Int J Colorectal Dis. 2012;27:927–30.PubMedCrossRef Hotouras A, Thaha MA, Allison ME, Currie A, Scott SM, Chan CL. Percutaneous tibial nerve stimulation (PTNS) in females with faecal incontinence: the impact of sphincter morphology and rectal sensation on the clinical outcome. Int J Colorectal Dis. 2012;27:927–30.PubMedCrossRef
37.
Zurück zum Zitat Munoz-Duyos A, Navarro-Luna A, Brosa M, Pando JA, Sitges-Serra A, Marco-Molina C. Clinical and cost effectiveness of sacral nerve stimulation for faecal incontinence. Br J Surg. 2008;95:1037–43.PubMedCrossRef Munoz-Duyos A, Navarro-Luna A, Brosa M, Pando JA, Sitges-Serra A, Marco-Molina C. Clinical and cost effectiveness of sacral nerve stimulation for faecal incontinence. Br J Surg. 2008;95:1037–43.PubMedCrossRef
38.
Zurück zum Zitat Leroi AM, Lenne X, Dervaux B, Chartier-Kastler E, Mauroy B, Normand LL, et al. Outcome and cost analysis of sacral nerve modulation for treating urinary and/or fecal incontinence. Ann Surg. 2011;253:720–32.PubMedCrossRef Leroi AM, Lenne X, Dervaux B, Chartier-Kastler E, Mauroy B, Normand LL, et al. Outcome and cost analysis of sacral nerve modulation for treating urinary and/or fecal incontinence. Ann Surg. 2011;253:720–32.PubMedCrossRef
39.
Zurück zum Zitat Hotouras A, Murphy J, Thin NN, Allison M, Horrocks E, Williams NS, Knowles CH, Chan CL. Outcome of sacral nerve stimulation (SNS) for fecal incontinence in patients refractory to percutaneous tibial nerve stimulation (PTNS). Dis Colon Rectum. 2013;56(7):915–20.PubMedCrossRef Hotouras A, Murphy J, Thin NN, Allison M, Horrocks E, Williams NS, Knowles CH, Chan CL. Outcome of sacral nerve stimulation (SNS) for fecal incontinence in patients refractory to percutaneous tibial nerve stimulation (PTNS). Dis Colon Rectum. 2013;56(7):915–20.PubMedCrossRef
40.
Zurück zum Zitat Hotouras A, Murphy J, Walsh U, Allison M, Curry A, Williams NS, Knowles CH, Chan CL. Outcome of percutaneous tibial nerve stimulation (PTNS) for fecal incontinence: a prospective cohort study. Ann Surg. 2014;259(5):939–43. Hotouras A, Murphy J, Walsh U, Allison M, Curry A, Williams NS, Knowles CH, Chan CL. Outcome of percutaneous tibial nerve stimulation (PTNS) for fecal incontinence: a prospective cohort study. Ann Surg. 2014;259(5):939–43.
Metadaten
Titel
Prospective clinical audit of two neuromodulatory treatments for fecal incontinence: sacral nerve stimulation (SNS) and percutaneous tibial nerve stimulation (PTNS)
verfasst von
Alexander Hotouras
Jamie Murphy
Marion Allison
Anne Curry
Norman S. Williams
Charles H. Knowles
Christopher L. Chan
Publikationsdatum
01.11.2014
Verlag
Springer Japan
Erschienen in
Surgery Today / Ausgabe 11/2014
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-014-0898-0

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