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Erschienen in: Archives of Virology 5/2012

01.05.2012 | Original Article

Etiology and epidemiology of viral diarrhea in children under the age of five hospitalized in Tianjin, China

verfasst von: Yabo Ouyang, Hui Ma, Min Jin, Xinwei Wang, Jingfeng Wang, Lu Xu, Shuxiang Lin, Zhiqiang Shen, Zhaoli Chen, Zhigang Qiu, Zhixian Gao, Lin Peng, Junwen Li

Erschienen in: Archives of Virology | Ausgabe 5/2012

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Abstract

Viral diarrhea is a great threat to children’s health in developing countries. We conducted a prospective surveillance study of acute diarrhea of young children at Tianjin Children’s Hospital from April 2008 to April 2009. Viral infections were detected in 356 of the total 766 collected stool specimens (46.48%). Rotavirus infections were the most common (27.94%; predominant type G1), followed by adenovirus infections (17.62%; predominant type Ad41), norovirus infections (5.87%; predominant type GII-4/2006b), and astrovirus infections (3.15%; only HAstV-1). Children younger than 1 year old were the most susceptible population to viral infections (87.9%). Diarrhea, vomiting, and fever were the most frequent clinical symptoms among the infected patients. The viral infections had no age, sex, or regional differences. Most infection rates were higher in the autumn, winter, and spring. This study supported that the rotavirus vaccine should be included in the Expanded Programme on Immunization in China.
Literatur
1.
Zurück zum Zitat Musher DM, Musher BL (2004) Contagious acute gastrointestinal infections. N Engl J Med 351:2417–2427PubMedCrossRef Musher DM, Musher BL (2004) Contagious acute gastrointestinal infections. N Engl J Med 351:2417–2427PubMedCrossRef
2.
Zurück zum Zitat Yee EL, Fang ZY, Liu N, Hadler SC, Liang X, Wang H, Zhu X, Jiang B, Parashar U, Widdowson MA, Glass RI (2009) Importance and challenges of accurately counting rotavirus deaths in China, 2002. Vaccine 27(Suppl 5):F46–F49PubMedCrossRef Yee EL, Fang ZY, Liu N, Hadler SC, Liang X, Wang H, Zhu X, Jiang B, Parashar U, Widdowson MA, Glass RI (2009) Importance and challenges of accurately counting rotavirus deaths in China, 2002. Vaccine 27(Suppl 5):F46–F49PubMedCrossRef
3.
Zurück zum Zitat China NBoSo (ed) (2009) China statistical yearbook China NBoSo (ed) (2009) China statistical yearbook
4.
Zurück zum Zitat Jin Y, Cheng WX, Yang XM, Jin M, Zhang Q, Xu ZQ, Yu JM, Zhu L, Yang SH, Liu N, Cui SX, Fang ZY, Duan ZJ (2009) Viral agents associated with acute gastroenteritis in children hospitalized with diarrhea in Lanzhou, China. J Clin Virol 44:238–241PubMedCrossRef Jin Y, Cheng WX, Yang XM, Jin M, Zhang Q, Xu ZQ, Yu JM, Zhu L, Yang SH, Liu N, Cui SX, Fang ZY, Duan ZJ (2009) Viral agents associated with acute gastroenteritis in children hospitalized with diarrhea in Lanzhou, China. J Clin Virol 44:238–241PubMedCrossRef
5.
Zurück zum Zitat Liu C, Grillner L, Jonsson K, Linde A, Shen K, Lindell AT, Wirgart BZ, Johansen K (2006) Identification of viral agents associated with diarrhea in young children during a winter season in Beijing, China. J Clin Virol 35:69–72PubMedCrossRef Liu C, Grillner L, Jonsson K, Linde A, Shen K, Lindell AT, Wirgart BZ, Johansen K (2006) Identification of viral agents associated with diarrhea in young children during a winter season in Beijing, China. J Clin Virol 35:69–72PubMedCrossRef
6.
Zurück zum Zitat Qiao H, Nilsson M, Abreu ER, Hedlund KO, Johansen K, Zaori G, Svensson L (1999) Viral diarrhea in children in Beijing, China. J Med Virol 57:390–396PubMedCrossRef Qiao H, Nilsson M, Abreu ER, Hedlund KO, Johansen K, Zaori G, Svensson L (1999) Viral diarrhea in children in Beijing, China. J Med Virol 57:390–396PubMedCrossRef
7.
Zurück zum Zitat Cunliffe NA, Booth JA, Elliot C, Lowe SJ, Sopwith W, Kitchin N, Nakagomi O, Nakagomi T, Hart CA, Regan M (2010) Healthcare-associated viral gastroenteritis among children in a large pediatric hospital, United Kingdom. Emerg Infect Dis 16:55–62PubMedCrossRef Cunliffe NA, Booth JA, Elliot C, Lowe SJ, Sopwith W, Kitchin N, Nakagomi O, Nakagomi T, Hart CA, Regan M (2010) Healthcare-associated viral gastroenteritis among children in a large pediatric hospital, United Kingdom. Emerg Infect Dis 16:55–62PubMedCrossRef
8.
Zurück zum Zitat China NBoSo (2010) China statistical yearbook China NBoSo (2010) China statistical yearbook
9.
Zurück zum Zitat Lee JI, Chung JY, Han TH, Song MO, Hwang ES (2007) Detection of human bocavirus in children hospitalized because of acute gastroenteritis. J Infect Dis 196:994–997PubMedCrossRef Lee JI, Chung JY, Han TH, Song MO, Hwang ES (2007) Detection of human bocavirus in children hospitalized because of acute gastroenteritis. J Infect Dis 196:994–997PubMedCrossRef
10.
Zurück zum Zitat Rohayem J, Berger S, Juretzek T, Herchenroder O, Mogel M, Poppe M, Henker J, Rethwilm A (2004) A simple and rapid single-step multiplex RT-PCR to detect Norovirus, Astrovirus and Adenovirus in clinical stool samples. J Virol Methods 118:49–59PubMedCrossRef Rohayem J, Berger S, Juretzek T, Herchenroder O, Mogel M, Poppe M, Henker J, Rethwilm A (2004) A simple and rapid single-step multiplex RT-PCR to detect Norovirus, Astrovirus and Adenovirus in clinical stool samples. J Virol Methods 118:49–59PubMedCrossRef
11.
Zurück zum Zitat Yan H, Yagyu F, Okitsu S, Nishio O, Ushijima H (2003) Detection of norovirus (GI, GII), Sapovirus and astrovirus in fecal samples using reverse transcription single-round multiplex PCR. J Virol Methods 114:37–44PubMedCrossRef Yan H, Yagyu F, Okitsu S, Nishio O, Ushijima H (2003) Detection of norovirus (GI, GII), Sapovirus and astrovirus in fecal samples using reverse transcription single-round multiplex PCR. J Virol Methods 114:37–44PubMedCrossRef
12.
Zurück zum Zitat Caro V, Guillot S, Delpeyroux F, Crainic R (2001) Molecular strategy for ‘serotyping’ of human enteroviruses. J Gen Virol 82:79–91PubMed Caro V, Guillot S, Delpeyroux F, Crainic R (2001) Molecular strategy for ‘serotyping’ of human enteroviruses. J Gen Virol 82:79–91PubMed
13.
Zurück zum Zitat O’Neill HJ, McCaughey C, Coyle PV, Wyatt DE, Mitchell F (2002) Clinical utility of nested multiplex RT-PCR for group F adenovirus, rotavirus and norwalk-like viruses in acute viral gastroenteritis in children and adults. J Clin Virol 25:335–343PubMedCrossRef O’Neill HJ, McCaughey C, Coyle PV, Wyatt DE, Mitchell F (2002) Clinical utility of nested multiplex RT-PCR for group F adenovirus, rotavirus and norwalk-like viruses in acute viral gastroenteritis in children and adults. J Clin Virol 25:335–343PubMedCrossRef
14.
Zurück zum Zitat Resque HR, Munford V, Castilho JG, Schmich H, Caruzo TA, Racz ML (2007) Molecular characterization of astrovirus in stool samples from children in Sao Paulo, Brazil. Mem Inst Oswaldo Cruz 102:969–974PubMedCrossRef Resque HR, Munford V, Castilho JG, Schmich H, Caruzo TA, Racz ML (2007) Molecular characterization of astrovirus in stool samples from children in Sao Paulo, Brazil. Mem Inst Oswaldo Cruz 102:969–974PubMedCrossRef
15.
Zurück zum Zitat Marie-Cardine A, Gourlain K, Mouterde O, Castignolles N, Hellot MF, Mallet E, Buffet-Janvresse C (2002) Epidemiology of acute viral gastroenteritis in children hospitalized in Rouen, France. Clin Infect Dis 34:1170–1178PubMedCrossRef Marie-Cardine A, Gourlain K, Mouterde O, Castignolles N, Hellot MF, Mallet E, Buffet-Janvresse C (2002) Epidemiology of acute viral gastroenteritis in children hospitalized in Rouen, France. Clin Infect Dis 34:1170–1178PubMedCrossRef
16.
Zurück zum Zitat Li CS, Chan PK, Tang JW (2009) Prevalence of diarrhea viruses in hospitalized children in Hong Kong in 2008. J Med Virol 81:1903–1911PubMedCrossRef Li CS, Chan PK, Tang JW (2009) Prevalence of diarrhea viruses in hospitalized children in Hong Kong in 2008. J Med Virol 81:1903–1911PubMedCrossRef
17.
Zurück zum Zitat Bahl R, Ray P, Subodh S, Shambharkar P, Saxena M, Parashar U, Gentsch J, Glass R, Bhan MK (2005) Incidence of severe rotavirus diarrhea in New Delhi, India, and G and P types of the infecting rotavirus strains. J Infect Dis 192(Suppl 1):S114–S119PubMedCrossRef Bahl R, Ray P, Subodh S, Shambharkar P, Saxena M, Parashar U, Gentsch J, Glass R, Bhan MK (2005) Incidence of severe rotavirus diarrhea in New Delhi, India, and G and P types of the infecting rotavirus strains. J Infect Dis 192(Suppl 1):S114–S119PubMedCrossRef
18.
Zurück zum Zitat Colomba C, De Grazia S, Giammanco GM, Saporito L, Scarlata F, Titone L, Arista S (2006) Viral gastroenteritis in children hospitalised in Sicily, Italy. Eur J Clin Microbiol Infect Dis 25:570–575PubMedCrossRef Colomba C, De Grazia S, Giammanco GM, Saporito L, Scarlata F, Titone L, Arista S (2006) Viral gastroenteritis in children hospitalised in Sicily, Italy. Eur J Clin Microbiol Infect Dis 25:570–575PubMedCrossRef
19.
Zurück zum Zitat Santos N, Hoshino Y (2005) Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine. Rev Med Virol 15:29–56PubMedCrossRef Santos N, Hoshino Y (2005) Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine. Rev Med Virol 15:29–56PubMedCrossRef
20.
Zurück zum Zitat Fang ZY, Yang H, Qi J, Zhang J, Sun LW, Tang JY, Ma L, Du ZQ, He AH, Xie JP, Lu YY, Ji ZZ, Zhu BQ, Wu HY, Lin SE, Xie HP, Griffin DD, Ivanoff B, Glass RI, Gentsch JR (2002) Diversity of rotavirus strains among children with acute diarrhea in China: 1998–2000 surveillance study. J Clin Microbiol 40:1875–1878PubMedCrossRef Fang ZY, Yang H, Qi J, Zhang J, Sun LW, Tang JY, Ma L, Du ZQ, He AH, Xie JP, Lu YY, Ji ZZ, Zhu BQ, Wu HY, Lin SE, Xie HP, Griffin DD, Ivanoff B, Glass RI, Gentsch JR (2002) Diversity of rotavirus strains among children with acute diarrhea in China: 1998–2000 surveillance study. J Clin Microbiol 40:1875–1878PubMedCrossRef
21.
Zurück zum Zitat Gurgel RG, Bohland AK, Vieira SC, Oliveira DM, Fontes PB, Barros VF, Ramos MF, Dove W, Nakagomi T, Nakagomi O, Correia JB, Cunliffe N, Cuevas LE (2009) Incidence of rotavirus and all-cause diarrhea in northeast Brazil following the introduction of a national vaccination program. Gastroenterology 137:1970–1975PubMedCrossRef Gurgel RG, Bohland AK, Vieira SC, Oliveira DM, Fontes PB, Barros VF, Ramos MF, Dove W, Nakagomi T, Nakagomi O, Correia JB, Cunliffe N, Cuevas LE (2009) Incidence of rotavirus and all-cause diarrhea in northeast Brazil following the introduction of a national vaccination program. Gastroenterology 137:1970–1975PubMedCrossRef
22.
Zurück zum Zitat Silva PA, Stark K, Mockenhaupt FP, Reither K, Weitzel T, Ignatius R, Saad E, Seidu-Korkor A, Bienzle U, Schreier E (2008) Molecular characterization of enteric viral agents from children in northern region of Ghana. J Med Virol 80:1790–1798PubMedCrossRef Silva PA, Stark K, Mockenhaupt FP, Reither K, Weitzel T, Ignatius R, Saad E, Seidu-Korkor A, Bienzle U, Schreier E (2008) Molecular characterization of enteric viral agents from children in northern region of Ghana. J Med Virol 80:1790–1798PubMedCrossRef
23.
Zurück zum Zitat Dey SK, Shimizu H, Phan TG, Hayakawa Y, Islam A, Salim AF, Khan AR, Mizuguchi M, Okitsu S, Ushijima H (2009) Molecular epidemiology of adenovirus infection among infants and children with acute gastroenteritis in Dhaka City, Bangladesh. Infect Genet Evol 9:518–522PubMedCrossRef Dey SK, Shimizu H, Phan TG, Hayakawa Y, Islam A, Salim AF, Khan AR, Mizuguchi M, Okitsu S, Ushijima H (2009) Molecular epidemiology of adenovirus infection among infants and children with acute gastroenteritis in Dhaka City, Bangladesh. Infect Genet Evol 9:518–522PubMedCrossRef
24.
Zurück zum Zitat Saderi H, Roustai MH, Sabahi F, Sadeghizadeh M, Owlia P, De Jong JC (2002) Incidence of enteric adenovirus gastroenteritis in Iranian children. J Clin Virol 24:1–5PubMedCrossRef Saderi H, Roustai MH, Sabahi F, Sadeghizadeh M, Owlia P, De Jong JC (2002) Incidence of enteric adenovirus gastroenteritis in Iranian children. J Clin Virol 24:1–5PubMedCrossRef
25.
Zurück zum Zitat Shimizu H, Phan TG, Nishimura S, Okitsu S, Maneekarn N, Ushijima H (2007) An outbreak of adenovirus serotype 41 infection in infants and children with acute gastroenteritis in Maizuru City, Japan. Infect Genet Evol 7:279–284PubMedCrossRef Shimizu H, Phan TG, Nishimura S, Okitsu S, Maneekarn N, Ushijima H (2007) An outbreak of adenovirus serotype 41 infection in infants and children with acute gastroenteritis in Maizuru City, Japan. Infect Genet Evol 7:279–284PubMedCrossRef
26.
Zurück zum Zitat Huh JW, Kim WH, Moon SG, Lee JB, Lim YH (2009) Viral etiology and incidence associated with acute gastroenteritis in a 5-year survey in Gyeonggi province, South Korea. J Clin Virol 44:152–156PubMedCrossRef Huh JW, Kim WH, Moon SG, Lee JB, Lim YH (2009) Viral etiology and incidence associated with acute gastroenteritis in a 5-year survey in Gyeonggi province, South Korea. J Clin Virol 44:152–156PubMedCrossRef
27.
Zurück zum Zitat Oh DY, Gaedicke G, Schreier E (2003) Viral agents of acute gastroenteritis in German children: prevalence and molecular diversity. J Med Virol 71:82–93PubMedCrossRef Oh DY, Gaedicke G, Schreier E (2003) Viral agents of acute gastroenteritis in German children: prevalence and molecular diversity. J Med Virol 71:82–93PubMedCrossRef
28.
Zurück zum Zitat Xu J, Yang Y, Sun J, Ding Y (2009) Molecular epidemiology of norovirus infection among children with acute gastroenteritis in Shanghai, China, 2001–2005. J Med Virol 81:1826–1830PubMedCrossRef Xu J, Yang Y, Sun J, Ding Y (2009) Molecular epidemiology of norovirus infection among children with acute gastroenteritis in Shanghai, China, 2001–2005. J Med Virol 81:1826–1830PubMedCrossRef
29.
Zurück zum Zitat Tu ET, Bull RA, Greening GE, Hewitt J, Lyon MJ, Marshall JA, McIver CJ, Rawlinson WD, White PA (2008) Epidemics of gastroenteritis during 2006 were associated with the spread of norovirus GII.4 variants 2006a and 2006b. Clin Infect Dis 46:413–420PubMedCrossRef Tu ET, Bull RA, Greening GE, Hewitt J, Lyon MJ, Marshall JA, McIver CJ, Rawlinson WD, White PA (2008) Epidemics of gastroenteritis during 2006 were associated with the spread of norovirus GII.4 variants 2006a and 2006b. Clin Infect Dis 46:413–420PubMedCrossRef
30.
Zurück zum Zitat Papaventsis DC, Dove W, Cunliffe NA, Nakagomi O, Combe P, Grosjean P, Hart CA (2008) Human astrovirus gastroenteritis in children, Madagascar, 2004–2005. Emerg Infect Dis 14:844–846PubMedCrossRef Papaventsis DC, Dove W, Cunliffe NA, Nakagomi O, Combe P, Grosjean P, Hart CA (2008) Human astrovirus gastroenteritis in children, Madagascar, 2004–2005. Emerg Infect Dis 14:844–846PubMedCrossRef
31.
Zurück zum Zitat Victoria M, Carvalho-Costa FA, Heinemann MB, Leite JP, Miagostovich MP (2007) Genotypes and molecular epidemiology of human astroviruses in hospitalized children with acute gastroenteritis in Rio de Janeiro, Brazil. J Med Virol 79:939–944PubMedCrossRef Victoria M, Carvalho-Costa FA, Heinemann MB, Leite JP, Miagostovich MP (2007) Genotypes and molecular epidemiology of human astroviruses in hospitalized children with acute gastroenteritis in Rio de Janeiro, Brazil. J Med Virol 79:939–944PubMedCrossRef
32.
Zurück zum Zitat Mendez-Toss M, Griffin DD, Calva J, Contreras JF, Puerto FI, Mota F, Guiscafre H, Cedillo R, Munoz O, Herrera I, Lopez S, Arias CF (2004) Prevalence and genetic diversity of human astroviruses in Mexican children with symptomatic and asymptomatic infections. J Clin Microbiol 42:151–157PubMedCrossRef Mendez-Toss M, Griffin DD, Calva J, Contreras JF, Puerto FI, Mota F, Guiscafre H, Cedillo R, Munoz O, Herrera I, Lopez S, Arias CF (2004) Prevalence and genetic diversity of human astroviruses in Mexican children with symptomatic and asymptomatic infections. J Clin Microbiol 42:151–157PubMedCrossRef
33.
Zurück zum Zitat Mitchell DK, Matson DO, Jiang X, Berke T, Monroe SS, Carter MJ, Willcocks MM, Pickering LK (1999) Molecular epidemiology of childhood astrovirus infection in child care centers. J Infect Dis 180:514–517PubMedCrossRef Mitchell DK, Matson DO, Jiang X, Berke T, Monroe SS, Carter MJ, Willcocks MM, Pickering LK (1999) Molecular epidemiology of childhood astrovirus infection in child care centers. J Infect Dis 180:514–517PubMedCrossRef
34.
Zurück zum Zitat Medici MC, Martinelli M, Arcangeletti MC, Pinardi F, De Conto F, Dodi I, Virdis R, Abelli LA, Aloisi A, Zerbini L, Valcavi P, Calderaro A, Bernasconi S, Izzi GC, Dettori G, Chezzi C (2004) Epidemiological aspects of human rotavirus infection in children hospitalized with acute gastroenteritis in an area of northern Italy. Acta Biomed 75:100–106PubMed Medici MC, Martinelli M, Arcangeletti MC, Pinardi F, De Conto F, Dodi I, Virdis R, Abelli LA, Aloisi A, Zerbini L, Valcavi P, Calderaro A, Bernasconi S, Izzi GC, Dettori G, Chezzi C (2004) Epidemiological aspects of human rotavirus infection in children hospitalized with acute gastroenteritis in an area of northern Italy. Acta Biomed 75:100–106PubMed
35.
Zurück zum Zitat Roman E, Wilhelmi I, Colomina J, Villar J, Cilleruelo ML, Nebreda V, Del Alamo M, Sanchez-Fauquier A (2003) Acute viral gastroenteritis: proportion and clinical relevance of multiple infections in Spanish children. J Med Microbiol 52:435–440PubMedCrossRef Roman E, Wilhelmi I, Colomina J, Villar J, Cilleruelo ML, Nebreda V, Del Alamo M, Sanchez-Fauquier A (2003) Acute viral gastroenteritis: proportion and clinical relevance of multiple infections in Spanish children. J Med Microbiol 52:435–440PubMedCrossRef
Metadaten
Titel
Etiology and epidemiology of viral diarrhea in children under the age of five hospitalized in Tianjin, China
verfasst von
Yabo Ouyang
Hui Ma
Min Jin
Xinwei Wang
Jingfeng Wang
Lu Xu
Shuxiang Lin
Zhiqiang Shen
Zhaoli Chen
Zhigang Qiu
Zhixian Gao
Lin Peng
Junwen Li
Publikationsdatum
01.05.2012
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 5/2012
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-012-1235-9

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