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Journal of Bone and Mineral Metabolism

Erschienen in:

01.03.2009 | Review Article

Choice of study phenotype in osteoporosis genetic research

verfasst von: Yuan Chen, Hui Shen, Fang Yang, Peng-Yuan Liu, Nelson Tang, Robert R. Recker, Hong-Wen Deng

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 2/2009

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Abstract

Osteoporosis is a common disease characterized by compromised bone strength predisposing a person to an increased risk of osteoporotic fracture (OF). Recently, extensive efforts have been made to identify candidate genes underlying osteoporosis by the use of surrogate phenotypes, such as bone mineral density (BMD) and bone geometry. Among them, BMD is a suitable choice if we aim to classify the role of biological pathways for bone strength and to understand the bone conditions in the development of osteoporosis. However, evidences show that the genetic correlation between BMD and OF is very limited. In this review, we are mainly concerned with an important issue, i.e., phenotype choice in osteoporosis genetic research. For clarity, we address this issue with several arguments, and comments are made on most representative literature.

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Titel: Choice of study phenotype in osteoporosis genetic research
verfasst von: Yuan Chen
Hui Shen
Fang Yang
Peng-Yuan Liu
Nelson Tang
Robert R. Recker
Hong-Wen Deng
Publikationsdatum: 01.03.2009
Verlag: Springer Japan
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 2/2009
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-008-0020-z

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