nach oben

Journal of Orthopaedic Science

Erschienen in:

01.01.2011 | Original article

The effect of Cox-2 specific inhibition on direct fracture healing in the rabbit tibia

verfasst von: David J. Hak, Kurt S. Schulz, Behrang Khoie, Scott J. Hazelwood

Erschienen in: Journal of Orthopaedic Science | Ausgabe 1/2011

Einloggen, um Zugang zu erhalten

Abstract

Objective

The purpose of this study was to evaluate the effect of Cox-2 administration on direct (primary) fracture healing.

Methods

A transverse tibial osteotomy was created in adult male rabbits and rigidly fixed in compression using a 2.7-mm dynamic compression plate. Animals were randomized to receive either rofecoxib (12.5 mg orally per day) or placebo. Animals were killed at 4 weeks and fracture healing assessed by mechanical testing.

Results

There were no significant differences between the control and Cox-2 treated animals in terms of mechanical strength at 4 weeks. There was a high complication rate of peri-implant fractures during the daily medication administration.

Conclusion

The immediate administration of a Cox-2 specific inhibitor did not impair primary (direct) bone healing at the dose administered in this rabbit tibial osteotomy model.

Allen HL, Wase A, Bear WT. Indomethicin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand. 1980;51:595–600.PubMedCrossRef

Altman RD, Latta LL, Keer R, Renfree K, Hornicek FJ, Banovac K. Effect of nonsteroidal anti-inflammatory drugs on fracture healing: a laboratory study in rats. J Orthop Trauma. 1995;9:392–400.PubMedCrossRef

Ho ML, Chang JK, Wang GJ. Antiinflammatory drug effects on bone repair and remodeling in rabbits. Clin Orthop. 1995;313:270–8.PubMed

Høgevold HE, Grøgaard B, Reikerås O. Effects of short-term treatment with corticosteroids and indomethacin on bone healing: a mechanical study of osteotomies in rats. Acta Orthop Scand. 1992;63:607–11.PubMed

Bergenstock M, Min W, Simon AM, Sabatino C, O’Connor JP. A comparison between the effects of acetaminophen and celecoxib on bone fracture healing in rats. J Orthop Trauma. 2005;19:717–23.PubMedCrossRef

Gerstenfeld LC, Al-Ghawas M, Alkhiary YM, Cullinane DM, Krall EA, Webb EG, Thiede MA, Einhorn TA. Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment. J Bone Joint Surg Am. 2007;89:114–25.PubMedCrossRef

Simon AM, O’Connor JP. Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg Am. 2007;89:500–11.PubMedCrossRef

Herbendick MA, Sprott D, Stills H, Lawless M. Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model. Am J Orthop. 2008;37:E133–7.

Goodman S, Ma T, Trindade M, Ikenoue T, Matsuura I, Wong N, Fox N, Genovese M, Regula D, Smith RL. Cox-2 selective NSAID decreases bone ingrowth in vivo. J Orthop Res. 2002;20:1164–9.PubMedCrossRef

10.

Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, Lines C, Riddell R, Morton D, Lanas A, Konstam MA, Baron JA. Adenomatous polyp prevention on Vioxx (APPROVe) trial investigators cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med. 2005;352:1092–102.PubMedCrossRef

11.

Nussmeier NA, Whelton AA, Brown MT, Langford RM, Hoeft A, Parlow JL, Boyce SW, Verburg KM. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. New Engl J Med. 2005;352:1081–91.PubMedCrossRef

12.

Reuben SS, Fingeroth R, Krushell R, Maciolek H. Evaluation of the safety of the perioperative administration of rofecoxib for total knee arthroplasty. J Arthroplasty. 2002;17:26–31.PubMedCrossRef

13.

Ruoff G, Lema M. Strategies in pain management: new and potential indications for Cox-2 specific inhibitors. J Pain Symptom Manage. 2003;25(2):S21–31.PubMedCrossRef

14.

Sinatra R. Role of Cox-2 inhibitors in the evolution of acute pain management. J Pain Symptom Manage. 2002;24(1):S18–27.PubMedCrossRef

15.

Sinatra R, Torres J, Bustos AM. Pain management after major orthopaedic surgery: current strategies and new concepts. J Am Acad Orthop Surg. 2002;10:117–29.PubMed

16.

Rahn BA, Gallinaro P, Baltensperger A, Perren SM. Primary bone healing: an experimental study in the rabbit. J Bone Joint Surg Am. 1971;53:783–6.PubMed

17.

White A, Panjabi M, Southwick W. The four biomechanical stages of fracture repair. J Bone Joint Surg Am. 1977;59:188–92.PubMed

18.

Terjesen T. Bone healing after metal plate fixation and external fixation of osteotomized rabbit tibia. Acta Orthop Scand. 1984;55:69–77.PubMedCrossRef

19.

Brown KM, Saunders MM, Kirsch T, Donahue HJ, Reid JS. Effect of COX-2-specific inhibition on fracture-healing in the rat femur. J Bone Joint Surg Am. 2004;86:116–23.PubMed

20.

Simon AM, Manigrasso MB, O’Connor JP. Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res. 2002;17:963–76.PubMedCrossRef

21.

Karachalios T, Boursinos L, Poultsides L, Khaldi L, Malizos KN. The effect of short-term administration of low therapeutic doses of anti-cox-2 agents on the healing of fractures: an experimental study in rabbits. J Bone Joint Surg Br. 2007;89:1253–60.PubMedCrossRef

22.

Mullis BH, Copland ST, Weinhold PS, Miclau T, Lester GE, Bos GD. Effect of cox-2 inhibitors and non-steroidal anti-inflammatory drugs on a mouse fracture model. Injury, Int J Care Injured. 2006;37:827–37.

23.

Gerstenfeld LC, Thiede M, Seibert K, Mielke C, Phippard D, Svagr B, Cullinane D, Einhorn TA. Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res. 2003;21:670–5.PubMedCrossRef

24.

Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O’Keefe RJ. Cyclooxygenase-2 regulated mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest. 2002;109:1405–25.PubMed

25.

Hochberg MC, Melin JM, Reicin A. Cox-2 inhibitors and fracture healing: an argument against such an effect. J Bone Miner Res. 2003;18:583.PubMedCrossRef

26.

Burd TA, Hughes MS, Anglen JO. Heterotopic ossification prophylaxis with indomethicin increases the risk of long-bone nonunion. J Bone Joint Surg Br. 2003;85:700–5.PubMed

27.

Giannoudis PV, MacDonald DA, Matthews SJ, Smith RM, Furlong AJ, De Boer P. Nonunion of the femoral diaphysis: the influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Joint Surg Br. 2000;82:655–8.PubMedCrossRef

Titel: The effect of Cox-2 specific inhibition on direct fracture healing in the rabbit tibia
verfasst von: David J. Hak
Kurt S. Schulz
Behrang Khoie
Scott J. Hazelwood
Publikationsdatum: 01.01.2011
Verlag: Springer Japan
Erschienen in: Journal of Orthopaedic Science / Ausgabe 1/2011
Print ISSN: 0949-2658
Elektronische ISSN: 1436-2023
DOI: https://doi.org/10.1007/s00776-010-0016-0

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen.
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Medizinstudium Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

03.05.2024 Fibromyalgiesyndrom Nachrichten

Bewegungs-, Dehnungs- und Entspannungsübungen im Wasser lindern die Beschwerden von Patientinnen mit Fibromyalgie besser als das Üben auf trockenem Land. Das geht aus einer spanisch-brasilianischen Vergleichsstudie hervor.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärzte und Psychotherapeuten.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2011

A validation study of the Brief Scale for Psychiatric problems in Orthopaedic Patients (BS-POP) for patients with chronic low back pain (verification of reliability, validity, and reproducibility)

A 5-year epidemiological study on the prevalence rate of idiopathic scoliosis in Tokyo: school screening of more than 250,000 children

Squeaking sound in total hip arthroplasty using ceramic-on-ceramic bearing surfaces

Intramedullary spinal cord metastasis following spontaneous malignant transformation from giant cell tumor of bone 16 years after pulmonary metastasis

Modular neck prostheses in DDH patients: 11-year results

A novel technique for impaction bone grafting in acetabular reconstruction of revision total hip arthroplasty using an ex vivo compaction device