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Journal of Orthopaedic Science

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01.07.2011 | Original Article

Serum 25-hydroxyvitamin D status in hip and spine-fracture patients in Japan

verfasst von: Mayumi Sakuma, Naoto Endo, Hiroshi Hagino, Atsushi Harada, Yasumoto Matsui, Tetsuo Nakano, Kozo Nakamura

Erschienen in: Journal of Orthopaedic Science | Ausgabe 4/2011

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Abstract

Background

Serum 25-hydroxyvitamin D (25(OH)D) is used as an index that reflects the level of vitamin D. We have previously reported, on the basis of a study in Sado in Niigata, that patients with hip fracture have lower serum 25(OH)D levels than non-hip-fracture cases. In this study, the serum 25(OH)D status in hip-fracture cases was examined in four regions in Japan. Although most hip-fracture patients have experienced past spine-compression fractures, the relationship of these fractures and 25(OH)D is unknown. Therefore, we also examined the 25(OH)D level in spine-compression fracture patients in the same locations and time periods.

Methods

The levels of 25(OH)D, intact parathyroid hormone (intact PTH), undercarboxylated osteocalcin (ucOC), urine N-terminal crosslinking telopeptide of type I collagen (NTX), and bone mineral density were examined in patients with hip and spine fracture due to osteoporosis in several regions in Japan.

Results

There were no significant differences in age, BMI, serum 25(OH)D, serum intact PTH, and serum ucOC among the regions. Levels of serum 25(OH)D were low in patients with hip fracture and spine fracture. The average serum 25(OH)D level was significantly lower in hip-fracture patients than in spine-fracture patients (16.3 vs. 18.1 ng/mL, P < 0.05). High serum ucOC was found in 37% of hip-fracture patients and 44% of spine-fracture patients.

Conclusions

Both hip and spine-fracture patients have vitamin D insufficiency, with similar results found in elderly patients in four areas of Japan. The severity of this condition tends to be more serious in hip-fracture patients than in spine-fracture patients.

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Titel: Serum 25-hydroxyvitamin D status in hip and spine-fracture patients in Japan
verfasst von: Mayumi Sakuma
Naoto Endo
Hiroshi Hagino
Atsushi Harada
Yasumoto Matsui
Tetsuo Nakano
Kozo Nakamura
Publikationsdatum: 01.07.2011
Verlag: Springer Japan
Erschienen in: Journal of Orthopaedic Science / Ausgabe 4/2011
Print ISSN: 0949-2658
Elektronische ISSN: 1436-2023
DOI: https://doi.org/10.1007/s00776-011-0089-4

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Springer Medizin

Serum 25-hydroxyvitamin D status in hip and spine-fracture patients in Japan

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Methods

Results

Conclusions

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