Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Clinical Oral Investigations
Erschienen in: Clinical Oral Investigations 6/2010

01.12.2010 | Original Article

Photodynamic therapy of persistent pockets in maintenance patients—a clinical study

verfasst von: Andreas Rühling, Jutta Fanghänel, Mohammad Houshmand, Alexander Kuhr, Peter Meisel, Christian Schwahn, Thomas Kocher

Erschienen in: Clinical Oral Investigations | Ausgabe 6/2010

Einloggen, um Zugang zu erhalten

Abstract

The aim of this study was to compare the short-term performance of a session of single photodynamic therapy (PDT) and of a conventional ultrasonic debridement (UST) in persistent pockets of maintenance patients. In a prospective, randomized, controlled, single-blind clinical study, patients with chronic periodontitis with at least two persistent pockets (>4 mm) were enrolled. They were treated either with UST (n = 29) or PDT (n = 25). Clinical and microbiological examinations were performed at baseline and after 3 month. For UST, the mean probing depth was reduced from 5.3 to 4.5 mm (p = <0.001) and for PDT from 5.3 to 4.7 mm (p < 0.001) with no difference between the two treatment modalities. Microbial counts were significantly reduced about 30% to 40% immediately after debridement but returned to baseline values at month 3 irrespective of treatment. PDT is not superior to conventional mechanical treatment of persistent pockets, but it may be a meaningful therapeutic alternative; the clinical effects were too minor to draw a definitive conclusion.
Literatur
1.
Adair G (1984) The Hawthorne effect: a reconsideration of the methodological artifact. J Appl Psychol 69:334–345CrossRef
2.
Bardet P, Suvan J, Lang N (1999) Clinical effects of root instrumentation using conventional steel or non-tooth substance removing plastic curettes during supportive periodontal therapy (SPT). J Clin Periodontol 26:742–747CrossRefPubMed
3.
Bertoloni G, Rossi F, Valduga G, Jori G, Ali H, van Lier JE (1992) Photosensitizing activity of water- and lipid-soluble phthalocyanines on prokaryotic and eukaryotic microbial cells. Microbios 71:33–46PubMed
4.
Bhatti M, Mac Robert A, Henderson B, Wilson M (2002) Exposure of Porphyromonas gingivalis to red light in the presence of the light-activated antimicrobial agent toluidine blue decreases membrane fluidity. Curr Microbiol 45:118–122CrossRefPubMed
5.
Bogren A, Teles RP, Torresyap G, Haffajee AD, Socransky SS, Wennström JL (2008) Locally delivered doxycycline during supportive periodontal therapy: a 3-year study. J Periodontol 79:827–835CrossRefPubMed
6.
Boutaga K, van Winkelhoff AJ, Vandenbroucke-Grauls CM, Savelkoul PH (2006) The additional value of real-time PCR in the quantitative detection of periodontal pathogens. J Clin Periodontol 33:427–433CrossRefPubMed
7.
Chondros P, Nikolidakis D, Christodoulides N, Rössler R, Gutknecht N, Sculean A (2009) Photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial. Lasers Med Sci 24:681–688CrossRefPubMed
8.
Cugini M, Haffajee AD, Smith C, Kent RL Jr, Socransky SS (2000) The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol 27:30–36CrossRefPubMed
9.
de Almeida JM, Theodoro LH, Bosco AF, Mj N, Oshiiwa M, Garcia VG (2008) In vivo effect of photodynamic therapy on periodontal bone loss in dental furcations. J Periodontol 79:1081–1088CrossRefPubMed
10.
De Oliveira RR, Schwartz-Filho HO, Novaes AB Jr, Taba M Jr (2007) Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: a preliminary randomized controlled clinical study. J Periodontol 78:965–973CrossRefPubMed
11.
Dobson J, Wilson M (1992) Sensitization of oral bacteria in biofilms to killing by light from a low-power laser. Arch Oral Biol 37:883–887CrossRefPubMed
12.
Dörtbudak O, Haas R, Bernhart T, Mailath-Pokorny G (2001) Lethal photosensitization for decontamination of implant surfaces in the treatment of peri-implantitis. Clin Oral Implants Res 12:104–108CrossRefPubMed
13.
Dragoo MR (1992) Clinical evaluation of hand and ultrasonic instruments on subgingival debridement with unmodified and modified ultrasonic inserts. Int J Periodontics Restor Dent 12:310–323
14.
Eickholz P, Kim TS, Schacher B, Reitmeir P, Burklin T, Ratka-Krüger P (2005) Subgingival topical doxycycline versus mechanical debridement for supportive periodontal therapy: a single blind randomized controlled two-center study. Am J Dent 18:341–346PubMed
15.
Greenstein G (2005) Position paper: the role of supra- and subgingival irrigation in the treatment of periodontal diseases. J Periodontol 76:2015–2027CrossRefPubMed
16.
Henderson BW (1992) Historical perspective. In: Henderson WH, Dougherty TJ (eds) Photodynaymic therapy. Basic principles and clinical applications. Marcel Dekker, New York, pp 1–15
17.
Jervøe-Storm PM, Koltzscher M, Falk W, Dörfler A, Jepsen S (2005) Comparison of culture and real-time PCR for detection and quantification of five putative periodontopathogenic bacteria in subgingival plaque samples. J Clin Periodontol 32:778–783CrossRefPubMed
18.
Kocher T, Fanghänel J, Schwahn C, Rühling A (2005) A new ultrasonic device in maintenance therapy: perception of pain and clinical efficacy. J Clin Periodontol 32:425–429CrossRefPubMed
19.
Kömerik N, Wilson M, Poole S (2000) The effect of photodynamic action on two virulence factors of gram-negative bacteria. Photochem Photobiol 72:676–680CrossRefPubMed
20.
Kömerik N, Curnow A, Mac Robert AJ, Hopper C, Speight PM, Wilson M (2002) Fluorescence biodistribution and photosensitising activity of toluidine blue o on rat buccal mucosa. Lasers Med Sci 17:86–92CrossRefPubMed
21.
Malik Z, Hanania J, Nitzan Y (1990) Bactericidal effects of photoactivated porphyrins—an alternative approach to antimicrobial drugs. J Photochem Photobiol B 5:281–293CrossRefPubMed
22.
Malik Z, Ladan H, Nitzan Y, Ehrenberg B (1990) The bactericidal activity of a deuteroporphyrin-hemin mixture on gram-positive bacteria. A microbiological and spectroscopic study. J Photochem Photobiol B 6:419–430CrossRefPubMed
23.
McColl E, Patel K, Dahlen G, Tonetti M, Graziani F, Suvan J, Laurell L (2006) Supportive periodontal therapy using mechanical instrumentation or 2% minocycline gel: a 12-month randomized, controlled, single masked pilot study. J Clin Periodontol 33:141–150CrossRefPubMed
24.
Meisel P, Kocher T (2005) Photodynamic therapy for periodontal diseases: state of the art. J Photochem Photobiol B 79:159–170CrossRefPubMed
25.
Müller P, Guggenheim B, Schmidlin PR (2007) Efficacy of gasiform ozone and photodynamic therapy on a multispecies oral biofilm in vitro. Eur J Oral Sci 115:77–80CrossRefPubMed
26.
Nosal G, Scheidt MJ, O’Neal R, van Dyke TE (1991) The penetration of lavage solution into the periodontal pocket during ultrasonic instrumentation. J Periodontol 62:554–557PubMed
27.
Petersilka GJ, Tunkel J, Barakos K, Heinecke A, Häberlein I, Flemmig TF (2003) Subgingival plaque removal at interdental sites using a low-abrasive air polishing powder. J Periodontol 74:307–311CrossRefPubMed
28.
Petersilka GJ, Draenert M, Mehl A, Hickel R, Flemmig TF (2003) Safety and efficiency of novel sonic scaler tips in vitro. J Clin Periodontol 30:551–555CrossRefPubMed
29.
Pfitzner A, Sigusch BW, Albrecht V, Glockmann E (2004) Killing of periodontopathogenic bacteria by photodynamic therapy. J Periodontol 75:1343–1349CrossRefPubMed
30.
Rabbani GM, Ash MM Jr, Caffesse RG (1981) The effectiveness of subgingival scaling and root planning in calculus removal. J Periodontol 52:119–123CrossRefPubMed
31.
Rhemrev GE, Timmerman MF, Veldkamp I, van Winkelhoff AJ, van der Velden U (2006) Immediate effect of instrumentation on the subgingival microflora in deep inflamed pockets under strict plaque control. J Clin Periodontol 33:42–48CrossRefPubMed
32.
Sharkey SM, Wilson BC, Moorehead R, Singh G (1993) Mitochondrial alterations in photodynamic therapy-resistant cells. Cancer Res 52:4994–4999
33.
Sigusch BW, Pfitzner A, Albrecht V, Glockmann E (2005) Efficacy of photodynamic therapy on inflammatory signs and two selected periodontopathogenic species in a beagle dog model. J Periodontol 76:1100–1105CrossRefPubMed
34.
Socransky SS, Haffajee AD, Smith C, Martin L, Haffajee JA, Uzel NG, Goodson JM (2004) Use of checkerboard DNA-DNA hybridization to study complex microbial ecosystems. Oral Microbiol Immunol 19:352–362CrossRefPubMed
35.
Soukos NS, Ximenez-Fyvie LA, Hamblin MR, Socransky SS, Hasan T (1998) Targeted antimicrobial photochemotherapy. Antimicrob Agents Chemother 42:2595–2601PubMed
36.
Soukos NS, Socransky SS, Mullholland SE, Lee S, Doukas AG (2000) Photomechanical drug delivery into bacterial biofilms. Pharm Res 17:405–409CrossRefPubMed
37.
Soukos NS, Mulholland SE, Socransky SS, Doukas AG (2003) Photodestruction of human dental plaque bacteria: enhancement of the photodynamic effect by photomechanical waves in an oral biofilm model. Lasers Surg Mes 33:161–168CrossRef
38.
Stambaugh RV, Dragoo M, Smith DM, Carasali L (1981) The limits of subgingival scaling. Int J Periodontic Restor 1:30–41
39.
Stojiljkovic I, Evavold BD, Kumar V (2001) Antimicrobial properties of porphyrins. Expert Opin Investig Drugs 10:309–320CrossRefPubMed
40.
Tomasi C, Schander K, Dahlen G, Wennström JL (2006) Short-term clinical and microbiologic effects of pocket debridement with an Er:YAG laser during periodontal maintenance. J Periodontol 77:111–118CrossRefPubMed
41.
Williams JA, Pearson GJ, Colles MJ (2006) Antibacterial action of photoactivated disinfection PAD used on endodontic bacteria in planktonic suspension and in artificial and human root canals. J Dentistry 34:363–371CrossRef
42.
Wilson M, Dobson J, Harvey W (1992) Sensitization of oral bacteria to killing by low-power laser radiation. Curr Microbiol 25:77–81CrossRefPubMed
43.
Wilson M, Pratten J (1995) Lethal photosensitisation of Staphylococcus aureus in vitro: effect of growth phase, serum, and pre-irradiation time. Lasers Surg Med 16:272–276CrossRefPubMed
44.
Wong MY, Lu CL, Liu CM, Hou L (1999) Microbiological response of localized sites with recurrent periodontitis in maintenance patients treated with tetracycline fibers. J Periodontol 70:861–868CrossRefPubMed
45.
Yilmaz S, Kuru B, Kuru L, Noyan U, Argun D, Kadir T (2002) Effect of gallium arsenide diode laser on human periodontal disease: a microbiological and clinical study. Lasers Surg Med 30:60–66CrossRefPubMed
Metadaten
Titel
Photodynamic therapy of persistent pockets in maintenance patients—a clinical study
verfasst von
Andreas Rühling
Jutta Fanghänel
Mohammad Houshmand
Alexander Kuhr
Peter Meisel
Christian Schwahn
Thomas Kocher
Publikationsdatum
01.12.2010
Verlag
Springer-Verlag
Erschienen in
Clinical Oral Investigations / Ausgabe 6/2010
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-009-0347-4

Weitere Artikel der Ausgabe 6/2010

Clinical Oral Investigations 6/2010 Zur Ausgabe

Original Article

Marginal adaptation of an etch-and-rinse adhesive with a new type of solvent in class II cavities after artificial aging

Original Article

Ex vivo radiographic tooth length measurements with the reference sphere method (RSM)

Letter to the Editor

Enucleation of keratocystic odontogenic tumours: study interpretation, technical refinement and future research

Original Article

Investigating interocclusal perception in tactile teeth sensibility using symmetric and asymmetric analysis

Original Article

Architectural characteristics of the normal and deformity mandible revealed by three-dimensional functional unit analysis

Original Article

Intraseptal vs. periodontal ligament anaesthesia for maxillary tooth extraction: quality of local anaesthesia and haemodynamic response

Neu im Fachgebiet Zahnmedizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

19.04.2024 Vorhofflimmern Nachrichten

Werden Personen mit Vorhofflimmern in der Blanking-Periode nach einer Katheterablation gegen eine bestehende Parodontitis behandelt, verbessert dies die Erfolgsaussichten. Dafür sprechen die Resultate einer prospektiven Untersuchung.

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

11.04.2024 Endokarditis Nachrichten

Bei welchen Personen eine Antibiotikaprophylaxe zur Prävention einer infektiösen Endokarditis nach invasiven zahnärztlichen Eingriffen sinnvoll ist, wird diskutiert. Neue Daten stehen im Einklang mit den europäischen Leitlinienempfehlungen.

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

08.04.2024 Zahnmedizin Nachrichten

Der Aufbau von Geweben und Organen während der Embryonalentwicklung wird von den Zellen bemerkenswert choreografiert. Für diesen Prozess braucht es spezielle sogenannte „Organisatoren“. In einer aktuellen Veröffentlichung im Fachjournal Nature Cell Biology berichten Forschende durch welchen Vorgang diese Organisatoren im Gewebe entstehen und wie sie dann die Bildung von Zähnen orchestrieren.

Die Oralprophylaxe & Kinderzahnheilkunde umbenannt

11.03.2024 Kinderzahnmedizin Nachrichten

Infolge der Umbenennung der Deutschen Gesellschaft für Kinderzahnheilkunde in Deutsche Gesellschaft für Kinderzahnmedizin (DGKiZ) wird deren Mitgliederzeitschrift Oralprophylaxe & Kinderzahnheilkunde in Oralprophylaxe & Kinderzahnmedizin umbenannt. Aus diesem Grunde trägt die erste Ausgabe in 2024 erstmalig den neuen Titel.

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen
Bildnachweise