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01.10.2007 | Original Paper

The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk

verfasst von: W. Cozen, J. R. Cerhan, O. Martinez-Maza, M. H. Ward, M. Linet, J. S. Colt, S. Davis, R. K. Severson, P. Hartge, L. Bernstein

Erschienen in: Cancer Causes & Control | Ausgabe 8/2007

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Abstract

Objective

Since adult immune responsiveness is influenced by early childhood exposures, we examined the role of family size, history of atopic disease, and other childhood immune-related exposures in a multi-center case–control study of NHL.

Methods

Interviews were completed with 1,321 cases ascertained from population-based cancer registries in Seattle, Detroit, Los Angeles and Iowa, and with 1,057 frequency-matched controls, selected by random-digit dialing and from the Medicare files database. Multivariable logistic regression was used to estimate risk.

Results

A history of any allergy (excluding drug allergies), decreased risk of all NHL (Odds Ratio [OR] = 0.7, 95% Confidence Interval [CI] = 0.6–1.0), diffuse large B-cell lymphoma [DLBCL] (OR = 0.6, 95% CI = 0.4–0.9), and follicular NHL (OR = 0.7, 95 CI = 0.5, 1.0). A similar effect was observed for hay fever. A history of eczema was associated with an increased risk of follicular lymphoma (OR = 1.9, 95% CI = 1.1–3.4), but not DLBCL (OR = 1.1, 95% CI = 0.6–2.0). Asthma did not affect risk. Youngest compared to oldest siblings had a 90% increased risk of DLBCL (95% CI = 1.2–3.1; p for trend with increasing birth order = 0.006), but not follicular lymphoma (OR = 1.1, 95% CI = 0.6–1.8).

Conclusions

We infer that some childhood and immune-related factors may alter NHL risk.

Grulich A, Vajdic C (2005) The epidemiology of non-Hodgkin lymphoma. Pathol 37:409–419CrossRef

Martinez F, Holt P (1999) Role of microbial burden in aetiology of allergy and asthma. Lancet 354(suppl II):12–15

Bernstein L, Ross R (1992) Prior medication use and health history as risk factors for non-Hodgkin’s lymphoma: preliminary results from a case-control study in Los Angeles County. Cancer Res 52:5510s–5515sPubMed

Doody M, Linet M, Glass A et al (1992) Leukemia, lymphoma and multiple myeloma following selected medical conditions. Cancer Causes Contr 3:449–456CrossRef

Holly E, Chitra L (1997) Non-Hodgkin’s lymphoma in HIV-positive and HIV-negative homosexual men in the San Francisco Bay area: Allergies, prior medication use, and sexual practices. J AIDS 15:211–222

Holly E, Lele C, Bracci P et al (1999) Case-control study of non-Hodgkin’s lymphoma among women and heterosexual men in the San Francisco Bay area, California. Am J Epidemiol 150:375–389PubMed

Vineis P, Crosignani P, Sacerdote C et al (2000) Haematopoietic cancer and medical history: a multicentre case control study. J Epidemiol Community Health 54:4331–4436

Tavani A, La Vecchia C, Franchesci S (2000) Medical history and the risk of non-Hodgkin lymphomas. Cancer Epidemiol Biomarkers Prev 1:533–6

Briggs N, Levine R, Brann E (2002) Allergies and risk of non-Hodgkin’s lymphoma by subtype. Cancer Epidemiol Biomarkers Prev 11:401–407PubMed

10.

Holly E, Bracci P (2003) Population-based study of non-Hodgkin lymphoma, histology and medical history among human immunodeficiency virus-negative participants in San Francisco. Am J Epidemiol 158:316–327PubMedCrossRef

11.

Grulich A, Vajdic C, Kaldor J et al (2004) Birth order, atopy, and risk of non-Hodgkin lymphoma. JNCI 97:587–594

12.

Bracci P, Dalvi T, Holly E (2006) Residential history, family characteristics and non-Hodgkin’s lymphoma, a population-based case-control study in the San Francisco Bay area. Cancer Epidemiol Biomarkers Prev 15:1287–1294PubMedCrossRef

13.

Zhang Y, Holdford T, Leaderer B et al (2004) Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut, United States women. Cancer Causes Contr 15:419–428CrossRef

14.

Melbye M, Smedby K, Lehtinen T et al (2007) Atopy and risk of non-Hodgkin lymphoma. JNCI 99:158–166PubMed

15.

Becker N, Deeg E, Rudiger T et al (2005) Medical history and risk for lymphoma: results of a population-based case-control study in Germany. Eur J Cancer 41:133–142PubMedCrossRef

16.

Strachan D (1989) Hay fever, hygiene and household size. Br Med J 299:1259–1260

17.

Strachan D, Taylor E, Carpenter R (1996) Family structure, neonatal infection and hay fever in adolescence. Arch Dis Child 74:422–426PubMedCrossRef

18.

Westergaard T, Melbye M, Pedersen J et al (1997) Birth order, sibship size and risk of Hodgkin’s disease in children and young adults: A population-based study of 31 million person-years. Int J Cancer 72:977–981PubMedCrossRef

19.

Gutensohn N, Cole P (1997) Epidemiology of Hodgkin’s disease in the young. Int J Cancer 19:595–604CrossRef

20.

Greaves M (2006) Infection, immune responses, aetiology of childhood leukaemia. Nat Rev Cancer 6:193–203PubMedCrossRef

21.

Vineis P, Miligi L, Crosignani P et al (2000) Delayed infection, family size and malignant lymphoma. J Epidemiol Community Health 54:907–911PubMedCrossRef

22.

Alitieri A, Castro F, Bermejo J et al Number of siblings and their risk of lymphoma, leukemia and myeloma by histopathology. Cancer Epidemiol Biomarkers Prev 15:1281–1286

23.

Becker N, Deeg E, Nieters A (2004) Population-based study of lymphoma in Germany: rationale, study design and first results. Leukemia Res 28:713–724CrossRef

24.

Ries L, Eisner M, Kosary C et al (2004) SEER cancer statistics review, 1975–2001. National Cancer Institute, National Institutes of Health, Bethesda, MD

25.

Percy C, Van Holten V, Muir C (eds) (1990) International classification of diseases for oncology, 2nd edn. World Health Organization, Geneva, Switzerland

26.

Fritz A, Percy C, Jack A et al (eds) (2000) International classification of diseases for oncology, 3rd edn. World Health Organization, Geneva, Switzerland

27.

Casady R, Lepkowski J (1993) Stratified telephone survey designs. Survey Method 19:103–113

28.

Kogevinas M, Zock J-P, Alvaro T et al (2004) Occupational exposure to immunologically active agents and risk for lymphoma. Cancer Epidemiol Biomarkers Prev 13:1814–1818PubMed

29.

Mills P, Beeson W, Fraser G et al (1992) Allergy and cancer: Organ-site specific results from the Adventist Health Study. Am J Epidemiol 136:287–95PubMed

30.

Wang H, Diepgen T (2005) Is atopy a protective or a risk factor for cancer? A review of epidemiologic studies. Allergy 60:1098–1111PubMedCrossRef

31.

Lindelof B, Granath F, Tengvall-Linder M et al (2005) Allergy and cancer. Allergy 60:1116–1120PubMedCrossRef

32.

Eriksson N, Holmen A, Hogstedt B et al (1995) A prospective study of cancer incidence in a cohort examined for allergy. Allergy 50:718–722PubMedCrossRef

33.

McWhorter W (1998) Allergy and risk of cancer: A prospective study using NHANESI followup data. Cancer 62:451–455CrossRef

34.

Talbot-Smith A, Fritschi L, Divtini M et al (2003) Allergy, atopy and cancer: A prospective study of the 1981 Busselton cohort. Am J Epidemiol 157:606–612PubMedCrossRef

35.

Soderberg KC, Hagmar K, Schwartzbaum J, Feychting M (2004) Allergic conditions and risk of hematologic malignancies in adults: a cohort study. BMC Public Health 4:51–57PubMedCrossRef

36.

Engels E (2007) Infectious agents as causes of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 16:401–404PubMedCrossRef

37.

Jarrett R (2006) Viruses and lymphoma/leukemia. J Pathol 208:176–86PubMedCrossRef

38.

Blaser M, Nomura A, Lee J, Stemmerman G, Perez-Perez G (2007) Early-life family structure and microbially induced cancer risk. PLOSMed 4:53–8

39.

Karmus W, Arshad S, Sadeghnejad A et al (2004) Does maternal immunoglobulin E decrease with increasing order of live offspring? Clin Exp Allergy 34:853–859CrossRef

40.

Green M, Zaadie Y (1989) Sibship size as a risk factor for Hepatitis A infection. Am J Epidemiol 129:800–805PubMed

41.

Downs S, Marks G, Mitakakis T et al (2001) Having lived on a farm and protection against allergic diseases in Australia. Clin Exp Allergy 3:570–575CrossRef

42.

von Mutius E, Braun-Fahrlander C, Schierl R et al (2000) Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 30:1230–1234CrossRef

43.

Lauener R, Birchler T, Adamski J et al (2002) Expression of CD14 and Toll-like receptor 2 in farmer’s children. Lancet 360:465–466PubMedCrossRef

44.

Nieters A, Beckmann L, Deeg E et al (2006) Gene polymorphisms in Toll-like receptors, interleukin-10, and receptor alpha and lymphoma risk. Genes Immunity 7:615–624PubMedCrossRef

45.

Forrest M, Skibola C, Lightfoot T et al (2006) Polymorphisms in innate immunity genes and risk of lymphoma. Br J Haematol 134:180–183PubMedCrossRef

46.

McCormick D, Ammann A, Ishizaka K et al (1971) A study of allergy in patients with malignant lymphoma and chronic lymphocytic leukemia. Cancer 27:93–99PubMedCrossRef

47.

Bahna S, Heiner D, Myhre B (1983) Immunoglobulin E pattern in cigarette smokers. Allergy 38:57–64PubMedCrossRef

48.

Harbison S, Robinson W (2002) Policy implications of the next world demographic transition. Studies Family Planning 33:37–48CrossRef

49.

Weitzman M, Gortmaker S, Sobol A et al (1992) Recent trends in the prevalence and severity of childhood asthma. JAMA 268:2673–2677PubMedCrossRef

50.

Cozen W, Gill P, Ingles S et al (2004) IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma. Blood 103:3216–3221PubMedCrossRef

Titel: The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk
verfasst von: W. Cozen
J. R. Cerhan
O. Martinez-Maza
M. H. Ward
M. Linet
J. S. Colt
S. Davis
R. K. Severson
P. Hartge
L. Bernstein
Publikationsdatum: 01.10.2007
Verlag: Kluwer Academic Publishers
Erschienen in: Cancer Causes & Control / Ausgabe 8/2007
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-007-9025-5

Springer Medizin

The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk