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01.09.2009 | Original Paper

Association of selenium, tocopherols, carotenoids, retinol, and 15-isoprostane F_2t in serum or urine with prostate cancer risk: the multiethnic cohort

verfasst von: Jasmeet K. Gill, Adrian A. Franke, J. Steven Morris, Robert V. Cooney, Lynne R. Wilkens, Loic Le Marchand, Marc T. Goodman, Brian E. Henderson, Laurence N. Kolonel

Erschienen in: Cancer Causes & Control | Ausgabe 7/2009

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Abstract

Objective

We examine the association of antioxidants and 15-isoprostane F_2t with risk of prostate cancer.

Methods

We conducted a nested case–control study of serum antioxidant biomarkers (selenium, tocopherols, carotenoids, and retinol) and a urinary oxidation biomarker (15-isoprostane F_2t) with risk of prostate cancer within the Multiethnic Cohort. Demographic, dietary, and other exposure information was collected by self-administered questionnaire in 1993–1996. We compared prediagnostic biomarker levels from 467 prostate cancer cases and 936 cancer free controls that were matched on several variables. Multivariate conditional logistic regression models were used to compute adjusted odds ratios (ORs) and 95% confidence intervals (CIs).

Results

We observed that there was no overall association of serum concentrations of antioxidants and urinary concentrations of 15-isoprostane F_2t with risk of prostate cancer or risk of advanced prostate cancer. However, we did observe an inverse association for serum selenium only among African-American men (p trend = 0.02); men in the third tertile of selenium concentrations had a 41% lower risk (95% CI: 0.38–0.93) of prostate cancer when compared to men in the first tertile.

Conclusions

Overall, our study found no association of serum antioxidants or 15-isoprostane F_2t with the risk of prostate cancer. The observed inverse association of selenium with prostate cancer in African-Americans needs to be validated in other studies.

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Titel: Association of selenium, tocopherols, carotenoids, retinol, and 15-isoprostane F2t in serum or urine with prostate cancer risk: the multiethnic cohort
verfasst von: Jasmeet K. Gill
Adrian A. Franke
J. Steven Morris
Robert V. Cooney
Lynne R. Wilkens
Loic Le Marchand
Marc T. Goodman
Brian E. Henderson
Laurence N. Kolonel
Publikationsdatum: 01.09.2009
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 7/2009
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-009-9304-4

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Association of selenium, tocopherols, carotenoids, retinol, and 15-isoprostane F_2t in serum or urine with prostate cancer risk: the multiethnic cohort