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Cancer Causes & Control
Erschienen in: Cancer Causes & Control 12/2010

01.12.2010 | Original paper

Young adulthood body mass index and risk of cancer in later adulthood: historical cohort study

verfasst von: Anya Burton, Richard Martin, Bruna Galobardes, George Davey Smith, Mona Jeffreys

Erschienen in: Cancer Causes & Control | Ausgabe 12/2010

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Abstract

Objective

To investigate the relationship between body mass index (BMI) in young adulthood and cancer incidence and mortality.

Methods

A total of 9,549 men and 2,657 women had weight and height measured while at university (1948–1968). Participants were traced through the National Health Service Central Register, and cancer registration and death certificates were obtained. Cox proportional hazard models were used to estimate hazard ratios (HR) of associations between BMI and cancer incidence and mortality.

Results

The mean age at university was 20 years. During a median follow-up of 49 years, 2,349 deaths occurred, including 55 breast, 111 prostate, and 131 colorectal cancer. There were 1,305 cancer registrations, including 102 breast, 211 prostate, and 125 colorectal cancers. There was weak evidence of an association between BMI and colorectal cancer incidence (adjusted HR per 1 kg/m2: 1.06, 95% CI: 0.98–1.15) and mortality (HR 1.05, 95% CI: 0.98–1.14). There was no evidence of an association between BMI and either breast or prostate cancer.

Conclusions

Targeting a reduction in obesity in young adulthood may prevent a significant number of colorectal cancer deaths, although whether this relationship is direct or through tracking to later adult BMI has yet to be established.
Literatur
1.
2.
World Cancer Research Fund/American Institute for Cancer Research (2007) Second expert report, food, nutrition, physical activity and the prevention of cancer: a global perspective
3.
Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348(17):1625–1638CrossRefPubMed
4.
Chu SY, Lee NC, Wingo PA, Senie RT, Greenberg RS, Peterson HB (1991) The relationship between body mass and breast cancer among women enrolled in the cancer and steroid hormone study. J Clin Epidemiol 44(11):1197–1206CrossRefPubMed
5.
Engeland A, Tretli S, Bjorge T (2003) Height, body mass index, and prostate cancer: a follow-up of 950000 Norwegian men. Br J Cancer 89(7):1237–1242CrossRefPubMed
6.
Le Marchand L, Wilkens LR, Mi MP (1992) Obesity in youth and middle age and risk of colorectal cancer in men. Cancer Causes Control 3(4):349–354CrossRefPubMed
7.
Whitlock G, Lewington S, Sherliker P et al (2009) Body-mass index and cause-specific mortality in 900,000 adults: collaborative analyses of 57 prospective studies. Lancet 373(9669):1083–1096CrossRefPubMed
8.
Kuh D, Ben-Shlomo Y (2004) A life course approach to chronic disease epidemiology. Oxford University Press, OxfordCrossRef
9.
Engeland A, Bjorge T, Sogaard AJ, Tverdal A (2003) Body mass index in adolescence in relation to total mortality: 32-year follow-up of 227,000 Norwegian boys and girls. Am J Epidemiol 157(6):517–523CrossRefPubMed
10.
Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH (1992) Long-term morbidity, mortality of overweight adolescents. A follow-up of the Harvard growth study of 1922 to 1935. N Engl J Med 327(19):1350–1355CrossRefPubMed
11.
Murthy NS, Mukherjee S, Ray G, Ray A (2009) Dietary factors and cancer chemoprevention: an overview of obesity-related malignancies. J Postgrad Med 55(1):45–54CrossRefPubMed
12.
Must A, Strauss RS (1999) Risks and consequences of childhood and adolescent obesity. Int J Obes Relat Metab Disord 23(Suppl 2):S2–S11CrossRefPubMed
13.
MacInnis RJ, English DR (2006) Body size and composition and prostate cancer risk: systematic review and meta-regression analysis. Cancer Causes Control 17(8):989–1003CrossRefPubMed
14.
Reeves GK, Pirie K, Beral V, Green J, Spencer E, Bull D (2007) Cancer incidence and mortality in relation to body mass index in the million women study: cohort study. BMJ 335(7630):1134CrossRefPubMed
15.
16.
McCarron P, Davey Smith G, Okasha M, McEwen J (1999) Life course exposure and later disease: a follow-up study based on medical examinations carried out in Glasgow University (1948–68). Public Health 113(6):265–271CrossRefPubMed
17.
Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Willett WC (1997) Height, body weight, and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 6(8):557–563PubMed
18.
Andersson SO, Wolk A, Bergstrom R et al (1997) Body size and prostate cancer: a 20-year follow-up study among 135006 Swedish construction workers. J Natl Cancer Inst 89(5):385–389CrossRefPubMed
19.
Robinson WR, Poole C, Godley PA (2008) Systematic review of prostate cancer’s association with body size in childhood and young adulthood. Cancer Causes Control 19(8):793–803CrossRefPubMed
20.
Moore LL, Bradlee ML, Singer MR et al (2004) BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham study adults. Int J Obes Relat Metab Disord 28(4):559–567CrossRefPubMed
21.
Larsson SC, Wolk A (2007) Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies. Am J Clin Nutr 86(3):556–565PubMed
22.
Giovannucci E, Michaud D (2007) The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology 132(6):2208–2225CrossRefPubMed
23.
Friedenreich CM (2001) Review of anthropometric factors and breast cancer risk. Eur J Cancer Prev 10(1):15–32CrossRefPubMed
24.
Carmichael AR (2006) Obesity as a risk factor for development and poor prognosis of breast cancer. BJOG 113(10):1160–1166CrossRefPubMed
25.
Key TJ, Appleby PN, Reeves GK et al (2003) Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 95(16):1218–1226CrossRefPubMed
26.
Solomon CG, Manson JE (1997) Obesity and mortality: a review of the epidemiologic data. Am J Clin Nutr 66(4 Suppl):1044S–1050SPubMed
27.
Okasha M, McCarron P, Gunnell D, Davey Smith G (2003) Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res Treat 78(2):223–276CrossRefPubMed
28.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578CrossRefPubMed
29.
McCarron P, Davey Smith G, Okasha M, McEwen J (2001) Smoking in adolescence and young adulthood and mortality in later life: prospective observational study. J Epidemiol Community Health 55(5):334–335CrossRefPubMed
30.
Davey SG, Sterne JA, Fraser A, Tynelius P, Lawlor DA, Rasmussen F (2009) The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study. BMJ 339:b5043CrossRef
31.
Moghaddam A, Woodward M, Huxley R (2007) Obesity and risk of colorectal cancer: a meta-analysis of 31 studies with 70,000 events. Cancer Epidemiol Biomarkers Prev 16(12):2533–2547CrossRefPubMed
32.
Lundqvist E, Kaprio J, Verkasalo PK et al (2007) Co-twin control and cohort analyses of body mass index and height in relation to breast, prostate, ovarian, corpus uteri, colon and rectal cancer among Swedish and Finnish twins. Int J Cancer 121(4):810–818CrossRefPubMed
33.
Jeffreys M, Davey Smith G, Martin RM, Frankel S, Gunnell D (2004) Childhood body mass index and later cancer risk: a 50-year follow-up of the Boyd Orr study. Int J Cancer 112(2):348–351CrossRefPubMed
34.
Whittemore AS, Paffenbarger RS Jr, Anderson K, Lee JE (1985) Early precursors of site-specific cancers in college men and women. J Natl Cancer Inst 74(1):43–51PubMed
35.
Lee IM, Paffenbarger RS Jr (1992) Quetelet’s index and risk of colon cancer in college alumni. J Natl Cancer Inst 84(17):1326–1331CrossRefPubMed
36.
Chute CG, Willett WC, Colditz GA et al (1991) A prospective study of body mass, height, and smoking on the risk of colorectal cancer in women. Cancer Causes Control 2(2):117–124CrossRefPubMed
37.
Bjorge T, Engeland A, Tverdal A, Davey Smith G (2008) Body mass index in adolescence in relation to cause-specific mortality: a follow-up of 230,000 Norwegian adolescents. Am J Epidemiol 168(1):30–37CrossRefPubMed
38.
Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC (1995) Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 122(5):327–334PubMed
39.
Harris RE, Namboodiri KK, Wynder EL (1992) Breast cancer risk: effects of estrogen replacement therapy and body mass. J Natl Cancer Inst 84(20):1575–1582CrossRefPubMed
40.
Le Marchand L, Kolonel LN, Earle ME, Mi MP (1988) Body size at different periods of life and breast cancer risk. Am J Epidemiol 128(1):137–152PubMed
41.
Paffenbarger RS Jr, Kampert JB, Chang HG (1980) Characteristics that predict risk of breast cancer before and after the menopause. Am J Epidemiol 112(2):258–268PubMed
42.
Hirose K, Tajima K, Hamajima N et al (1999) Effect of body size on breast-cancer risk among Japanese women. Int J Cancer 80(3):349–355CrossRefPubMed
43.
Brinton LA, Swanson CA (1992) Height and weight at various ages and risk of breast cancer. Ann Epidemiol 2(5):597–609CrossRefPubMed
44.
Huang Z, Hankinson SE, Colditz GA et al (1997) Dual effects of weight and weight gain on breast cancer risk. JAMA 278(17):1407–1411CrossRefPubMed
45.
Radimer K, Siskind V, Bain C, Schofield F (1993) Relation between anthropometric indicators and risk of breast cancer among Australian women. Am J Epidemiol 138(2):77–89PubMed
46.
Trentham-Dietz A, Newcomb PA, Storer BE et al (1997) Body size and risk of breast cancer. Am J Epidemiol 145(11):1011–1019PubMed
47.
Ruder EH, Dorgan JF, Kranz S, Kris-Etherton PM, Hartman TJ (2008) Examining breast cancer growth and lifestyle risk factors: early life, childhood, and adolescence. Clin Breast Cancer 8(4):334–342CrossRefPubMed
48.
Coates RJ, Uhler RJ, Hall HI et al (1999) Risk of breast cancer in young women in relation to body size and weight gain in adolescence and early adulthood. Br J Cancer 81(1):167–174CrossRefPubMed
49.
Peacock SL, White E, Daling JR, Voigt LF, Malone KE (1999) Relation between obesity and breast cancer in young women. Am J Epidemiol 149(4):339–346PubMed
50.
Weiderpass E, Braaten T, Magnusson C et al (2004) A prospective study of body size in different periods of life and risk of premenopausal breast cancer. Cancer Epidemiol Biomarkers Prev 13(7):1121–1127PubMed
51.
Michels K, Terry K, Willett W (2006) Longitudinal study on the role of body size in premenopausal breast cancer. Arch Intern Med 166(21):2395–2402CrossRefPubMed
52.
van den Brandt PA, Spiegelman D, Yaun SS et al (2000) Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 152(6):514–527CrossRefPubMed
53.
Baer H, Colditz G, Rosner B et al (2005) Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study. Breast Cancer Res 7(3):R314–R325CrossRefPubMed
54.
Forman MR, Cantwell MM, Ronckers C, Zhang Y (2005) Through the looking glass at early-life exposures and breast cancer risk. Cancer Invest 23(7):609–624CrossRefPubMed
55.
Hsing AW, Sakoda LC, Chua SC Jr (2007) Obesity, metabolic syndrome, and prostate cancer. Am J Clin Nutr 86(3):843S–857S
56.
Freedland SJ, Platz EA (2007) Obesity and prostate cancer: making sense out of apparently conflicting data. Epidemiol Rev 29:88–97CrossRefPubMed
57.
Robinson WR, Stevens J, Gammon MD, John EM (2005) Obesity before age 30 years and risk of advanced prostate cancer. Am J Epidemiol 161(12):1107–1114CrossRefPubMed
58.
Dal ML, Zucchetto A, La VC et al (2004) Prostate cancer and body size at different ages: an Italian multicentre case-control study. Br J Cancer 90(11):2176–2180
59.
Jonsson F, Wolk A, Pedersen NL et al (2003) Obesity and hormone-dependent tumors: cohort and co-twin control studies based on the Swedish Twin Registry. Int J Cancer 106(4):594–599CrossRefPubMed
60.
Giles GG, Severi G, English DR et al (2003) Early growth, adult body size and prostate cancer risk. Int J Cancer 103(2):241–245CrossRefPubMed
61.
Giovannucci E, Rimm EB, Liu Y et al (2003) Body mass index and risk of prostate cancer in U.S. health professionals. J Natl Cancer Inst 95(16):1240–1244CrossRefPubMed
62.
Gapstur SM, Gann PH, Kopp P, Colangelo L, Longcope C, Liu K (2002) Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study. Cancer Epidemiol Biomarkers Prev 11(10 Pt 1):1041–1047PubMed
63.
Wright ME, Chang SC, Schatzkin A et al (2007) Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality. Cancer 109(4):675–684CrossRefPubMed
64.
Hsing AW, Chua S Jr, Gao YT et al (2001) Prostate cancer risk and serum levels of insulin and leptin: a population-based study. J Natl Cancer Inst 93(10):783–789CrossRefPubMed
65.
Davey Smith G, Gunnell D, Holly J (2000) Cancer and insulin-like growth factor-I. A potential mechanism linking the environment with cancer risk. BMJ 321(7265):847–848CrossRef
66.
Chang S, Hursting SD, Contois JH et al (2001) Leptin and prostate cancer. Prostate 46(1):62–67CrossRefPubMed
67.
Renehan AG, Roberts DL, Dive C (2008) Obesity and cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem 114(1):71–83CrossRefPubMed
Metadaten
Titel
Young adulthood body mass index and risk of cancer in later adulthood: historical cohort study
verfasst von
Anya Burton
Richard Martin
Bruna Galobardes
George Davey Smith
Mona Jeffreys
Publikationsdatum
01.12.2010
Verlag
Springer Netherlands
Erschienen in
Cancer Causes & Control / Ausgabe 12/2010
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-010-9625-3

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